Sökning: onr:"swepub:oai:gup.ub.gu.se/288019" > Cathelicidin Contri...
Fältnamn | Indikatorer | Metadata |
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000 | 03709naa a2200661 4500 | |
001 | oai:gup.ub.gu.se/288019 | |
003 | SwePub | |
008 | 240910s2019 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:142442988 | |
024 | 7 | a https://gup.ub.gu.se/publication/2880192 URI |
024 | 7 | a https://doi.org/10.3389/fimmu.2019.026972 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1424429882 URI |
040 | a (SwePub)gud (SwePub)ki | |
041 | a eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Crauwels, P.4 aut |
245 | 1 0 | a Cathelicidin Contributes to the Restriction of Leishmania in Human Host Macrophages |
264 | c 2019-11-22 | |
264 | 1 | b Frontiers Media SA,c 2019 |
520 | a In cutaneous Leishmaniasis the parasitic control in human host macrophages is still poorly understood. We found an increased expression of the human cathelicidin CAMP in skin lesions of Ethiopian patients with cutaneous leishmaniasis. Vitamin D driven, Cathelicidin-type antimicrobial peptides (CAMP) play an important role in the elimination of invading microorganisms. Recombinant cathelicidin was able to induce cell-death characteristics in Leishmania in a dose dependent manner. Using human primary macrophages, we demonstrated pro-inflammatory macrophages (hMDM1) to express a higher level of human cathelicidin, both on gene and protein level, compared to anti-inflammatory macrophages (hMDM2). Activating the CAMP pathway using Vitamin D in hMDM1 resulted in a cathelicidin-mediated-Leishmania restriction. Finally, a reduction of cathelicidin in hMDM1, using a RNA interference (RNAi) approach, increased Leishmania parasite survival. In all, these data show the human cathelicidin to contribute to the innate immune response against Leishmaniasis in a human primary cell model. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Immunologi inom det medicinska området0 (SwePub)301102 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Immunology in the medical area0 (SwePub)301102 hsv//eng |
653 | a Leishmania | |
653 | a human macrophages | |
653 | a vitamin D | |
653 | a cathelicidin (LL-37) | |
653 | a human | |
653 | a primary immune cells | |
653 | a antimicrobial activity | |
653 | a vitamin-d-receptor | |
653 | a nitric-oxide | |
653 | a cutting edge | |
653 | a antimicrobial peptides | |
653 | a immune-response | |
653 | a camp gene | |
653 | a ll-37 | |
653 | a infection | |
653 | a skin | |
653 | a induction | |
653 | a Immunology | |
700 | 1 | a Bank, E.4 aut |
700 | 1 | a Walber, B.4 aut |
700 | 1 | a Wenzel, Ulf Alexander,d 1975u Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi,Institute of Biomedicine, Department of Microbiology and Immunology4 aut0 (Swepub:gu)xwenal |
700 | 1 | a Agerberth, B.u Karolinska Institutet4 aut |
700 | 1 | a Chanyalew, M.4 aut |
700 | 1 | a Abebe, M.4 aut |
700 | 1 | a Konig, R.4 aut |
700 | 1 | a Ritter, U.4 aut |
700 | 1 | a Reiling, N.4 aut |
700 | 1 | a van Zandbergen, G.4 aut |
710 | 2 | a Göteborgs universitetb Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi4 org |
773 | 0 | t Frontiers in Immunologyd : Frontiers Media SAg 10q 10x 1664-3224 |
856 | 4 | u https://doi.org/10.3389/fimmu.2019.02697 |
856 | 4 8 | u https://gup.ub.gu.se/publication/288019 |
856 | 4 8 | u https://doi.org/10.3389/fimmu.2019.02697 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:142442988 |
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