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Comparison of plasm...
Comparison of plasma and cerebrospinal fluid neurofilament light in a multiple sclerosis trial.
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- de Flon, Pierre, 1966- (författare)
- Umeå universitet,Klinisk neurovetenskap
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- Laurell, Katarina, 1967- (författare)
- Umeå universitet,Klinisk neurovetenskap
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- Sundström, Peter (författare)
- Umeå universitet,Klinisk neurovetenskap
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- Blennow, Kaj, 1958 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology at Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden
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- Söderström, Lars (författare)
- Umeå universitet,Klinisk neurovetenskap
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- Zetterberg, Henrik, 1973 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology at Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden; Department of Molecular Neuroscience, UCL Institute of Neurology, Queen Square, London, UK; UK Dementia Research Institute at UCL, London, UK
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- Gunnarsson, Martin, 1973- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Department of Neurology
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- Svenningsson, Anders (författare)
- Karolinska Institutet,Umeå universitet,Klinisk neurovetenskap,Department of Clinical Sciences, Karolinska Institute Danderyd Hospital, Stockholm, Sweden
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(creator_code:org_t)
- 2019-03-05
- 2019
- Engelska.
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Ingår i: Acta neurologica Scandinavica. - : Hindawi Limited. - 1600-0404 .- 0001-6314. ; 139:5, s. 462-468
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- The main objective of this study was to evaluate the axonal component neurofilament light protein (NFL) in plasma and cerebrospinal fluid (CSF) as an outcome measure in a clinical trial on disease-modifying treatments in multiple sclerosis.Seventy-five patients with clinically stable relapsing-remitting multiple sclerosis (RRMS) participating in the clinical trial "Switch-To RItuXimab in MS" (STRIX-MS) were switched to rituximab from first-line injectable therapy and then followed up for 2years. Thirty patients from the extension trial (STRIX-MS extension), accepting repeated lumbar punctures, were followed up for an additional 3years. Plasma and CSF samples were collected yearly during the follow-up. NFL concentration in plasma was measured by an in-house NF-light assay on the Simoa platform with a Homebrew kit. NFL concentration in CSF was measured by sandwich ELISA.The mean levels of NFL, in both CSF and plasma, were low. The reduction of CSF-NFL was 25% during the first year of follow-up (from a mean of 471 [SD 393] to 354 [SD 174]pg/mL; P=0.006) and was statistically significant. The corresponding reduction in plasma NFL was 18% (from 9.73 [SD 7.04] to 7.94 [SD 3.10]pg/mL; P=0.055) and did not reach statistical significance.This study indicates that NFL in plasma is less sensitive as an endpoint in group comparisons than NFL in CSF. Given that plasma NFL is far easier to access, it is a promising and awaited method but further studies are needed to optimize the use in clinical trials.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Nyckelord
- Adult
- Biomarkers
- analysis
- Enzyme-Linked Immunosorbent Assay
- Female
- Humans
- Immunologic Factors
- therapeutic use
- Male
- Middle Aged
- Multiple Sclerosis
- Relapsing-Remitting
- drug therapy
- metabolism
- Neurofilament Proteins
- analysis
- metabolism
- Rituximab
- therapeutic use
- Multiple sclerosis
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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de Flon, Pierre, ...
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Laurell, Katarin ...
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Sundström, Peter
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Blennow, Kaj, 19 ...
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Söderström, Lars
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Zetterberg, Henr ...
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Gunnarsson, Mart ...
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Svenningsson, An ...
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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och Neurovetenskaper
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Neurologi
- Artiklar i publikationen
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Acta neurologica ...
- Av lärosätet
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Göteborgs universitet
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Örebro universitet
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Umeå universitet
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Karolinska Institutet