Sökning: onr:"swepub:oai:gup.ub.gu.se/289238" > Dinucleotide Degrad...
Fältnamn | Indikatorer | Metadata |
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000 | 04540naa a2200709 4500 | |
001 | oai:gup.ub.gu.se/289238 | |
003 | SwePub | |
008 | 240528s2019 | |||||||||||000 ||eng| | |
009 | oai:DiVA.org:umu-166839 | |
009 | oai:prod.swepub.kib.ki.se:142454610 | |
024 | 7 | a https://gup.ub.gu.se/publication/2892382 URI |
024 | 7 | a https://doi.org/10.1016/j.molcel.2019.09.0102 DOI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1668392 URI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1424546102 URI |
040 | a (SwePub)gud (SwePub)umud (SwePub)ki | |
041 | a eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Nicholls, Thomas J.u Gothenburg University,Göteborgs universitet,Institutionen för biomedicin,Institute of Biomedicine4 aut |
245 | 1 0 | a Dinucleotide Degradation by REXO2 Maintains Promoter Specificity in Mammalian Mitochondria |
264 | 1 | b Elsevier BV,c 2019 |
520 | a Oligoribonucleases are conserved enzymes that degrade short RNA molecules of up to 5 nt in length and are assumed to constitute the final stage of RNA turnover. Here we demonstrate that REXO2 is a specialized dinucleotide-degrading enzyme that shows no preference between RNA and DNA dinucleotide substrates. A heart- and skeletal-muscle-specific knockout mouse displays elevated dinucleotide levels and alterations in gene expression patterns indicative of aberrant dinucleotide-primed transcription initiation. We find that dinucleotides act as potent stimulators of mitochondrial transcription initiation in vitro. Our data demonstrate that increased levels of dinucleotides can be used to initiate transcription, leading to an increase in transcription levels from both mitochondrial promoters and other, nonspecific sequence elements in mitochondrial DNA. Efficient RNA turnover by REXO2 is thus required to maintain promoter specificity and proper regulation of transcription in mammalian mitochondria. | |
650 | 7 | a NATURVETENSKAPx Biologix Biokemi och molekylärbiologi0 (SwePub)106022 hsv//swe |
650 | 7 | a NATURAL SCIENCESx Biological Sciencesx Biochemistry and Molecular Biology0 (SwePub)106022 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Cell- och molekylärbiologi0 (SwePub)301082 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Cell and Molecular Biology0 (SwePub)301082 hsv//eng |
653 | a escherichia-coli | |
653 | a transcription initiation | |
653 | a stranded-rna | |
653 | a in-vitro | |
653 | a oligoribonuclease | |
653 | a polymerase | |
653 | a DNA | |
653 | a maintenance | |
653 | a component | |
653 | a model | |
653 | a Biochemistry & Molecular Biology | |
653 | a Cell Biology | |
700 | 1 | a Spahr, H.u Karolinska Institutet4 aut |
700 | 1 | a Jiang, S.u Karolinska Institutet4 aut |
700 | 1 | a Sharma, Sushmau Umeå universitet,Institutionen för medicinsk kemi och biofysik4 aut0 (Swepub:umu)sush0003 |
700 | 1 | a Koolmeister, C.u Karolinska Institutet4 aut |
700 | 1 | a Sharma, S.4 aut |
700 | 1 | a Kauppila, J. H. K.4 aut |
700 | 1 | a Jiang, M.4 aut |
700 | 1 | a Kaever, V.4 aut |
700 | 1 | a Rackham, O.4 aut |
700 | 1 | a Chabes, Andrei,c Professoru Umeå universitet,Institutionen för medicinsk kemi och biofysik4 aut0 (Swepub:umu)anch0002 |
700 | 1 | a Falkenberg, Maria,d 1968u Gothenburg University,Göteborgs universitet,Institutionen för biomedicin,Institute of Biomedicine4 aut0 (Swepub:gu)xfamar |
700 | 1 | a Filipovska, A.4 aut |
700 | 1 | a Larsson, N. G.u Karolinska Institutet4 aut |
700 | 1 | a Gustafsson, Claes M,d 1966u Gothenburg University,Göteborgs universitet,Institutionen för biomedicin,Institute of Biomedicine4 aut0 (Swepub:gu)xgucla |
710 | 2 | a Göteborgs universitetb Institutionen för biomedicin4 org |
773 | 0 | t Molecular Celld : Elsevier BVg 76:5q 76:5x 1097-2765x 1097-4164 |
856 | 4 | u http://www.cell.com/article/S1097276519306951/pdf |
856 | 4 | u https://doi.org/10.1016/j.molcel.2019.09.010y Fulltext |
856 | 4 | u https://umu.diva-portal.org/smash/get/diva2:1382333/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
856 | 4 8 | u https://gup.ub.gu.se/publication/289238 |
856 | 4 8 | u https://doi.org/10.1016/j.molcel.2019.09.010 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-166839 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:142454610 |
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