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FältnamnIndikatorerMetadata
00007898naa a2200781 4500
001oai:gup.ub.gu.se/289671
003SwePub
008240528s2020 | |||||||||||000 ||eng|
009oai:DiVA.org:umu-170419
009oai:DiVA.org:uu-410139
0247 a https://gup.ub.gu.se/publication/2896712 URI
0247 a https://doi.org/10.1016/j.jaci.2019.08.0302 DOI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1704192 URI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4101392 URI
040 a (SwePub)gud (SwePub)umud (SwePub)uu
041 a eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Johannessen, A.u Univ Bergen, Dept Global Publ Hlth & Primary Care, N-5021 Bergen, Norway;Haukeland Hosp, Dept Occupat Med, Bergen, Norway4 aut
2451 0a Being overweight in childhood, puberty, or early adulthood: Changing asthma risk in the next generation?
264 1b Elsevier BV,c 2020
520 a Background: Overweight status and asthma have increased during the last decades. Being overweight is a known risk factor for asthma, but it is not known whether it might also increase asthma risk in the next generation. Objective: We aimed to examine whether parents being overweight in childhood, adolescence, or adulthood is associated with asthma in their offspring. Methods: We included 6347 adult offspring (age, 18-52 years) investigated in the Respiratory Health in Northern Europe, Spain and Australia (RHINESSA) multigeneration study of 2044 fathers and 2549 mothers (age, 37-66 years) investigated in the European Community Respiratory Health Survey (ECRHS) study. Associations of parental overweight status at age 8 years, puberty, and age 30 years with offspring's childhood overweight status (potential mediator) and offspring's asthma with or without nasal allergies (outcomes) was analyzed by using 2-level logistic regression and 2-level multinomial logistic regression, respectively. Counterfactual-based mediation analysis was performed to establish whether observed associations were direct or indirect effects mediated through the offspring's own overweight status. Results: We found statistically significant associations between both fathers' and mothers' childhood overweight status and offspring's childhood overweight status (odds ratio, 2.23 [95% CI, 1.45-3.42] and 2.45 [95% CI, 1.86-3.22], respectively). We also found a statistically significant effect of fathers' onset of being overweight in puberty on offspring's asthma without nasal allergies (relative risk ratio, 2.31 [95% CI, 1.23-4.33]). This effect was direct and not mediated through the offspring's own overweight status. No effect on offspring's asthma with nasal allergies was found. Conclusion: Our findings suggest that metabolic factors long before conception can increase asthma risk and that male puberty is a time window of particular importance for offspring's health. © 2019 The Authors
650 7a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi0 (SwePub)303022 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Public Health, Global Health, Social Medicine and Epidemiology0 (SwePub)303022 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Immunologi inom det medicinska området0 (SwePub)301102 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Immunology in the medical area0 (SwePub)301102 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Lungmedicin och allergi0 (SwePub)302192 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Respiratory Medicine and Allergy0 (SwePub)302192 hsv//eng
653 a Ageing Lungs in European Cohorts study
653 a epidemiology
653 a multilevel mediation model
653 a offspring
653 a parental risk factors
653 a Ageing Lungs in European Cohorts study
7001 a Lønnebotn, M.u Univ Bergen, Dept Global Publ Hlth & Primary Care, N-5021 Bergen, Norway;Haukeland Hosp, Dept Occupat Med, Bergen, Norway4 aut
7001 a Calciano, L.u Univ Verona, Dept Diagnost & Publ Hlth, Unit Epidemiol & Med Stat, Verona, Italy4 aut
7001 a Benediktsdóttir, B.u Univ Iceland, Fac Med, Reykjavik, Iceland;Landspitali Univ Hosp, Dept Sleep, Reykjavik, Iceland4 aut
7001 a Bertelsen, R. J.u Univ Bergen, Dept Clin Sci, Bergen, Norway,Tartu Univ Hosp, Lung Clin, Tartu, Estonia4 aut
7001 a Bråbäck, Lennartu Umeå universitet,Avdelningen för hållbar hälsa,Dept Publ Hlth & Clin Med, Occupat & Environm Med, Umeå, Sweden4 aut0 (Swepub:umu)lebr0005
7001 a Dharmage, S.u Univ Melbourne, Sch Populat & Global Hlth, Allergy & Lung Hlth Unit, Melbourne, Vic, Australia4 aut
7001 a Franklin, Karl Au Umeå universitet,Kirurgi,Umeå Univ, Surg, Dept Surg & Perioperat Sci, Umeå, Sweden4 aut0 (Swepub:umu)kafr0021
7001 a Gislason, T.u Landspitali Univ Hosp, Dept Sleep, Reykjavik, Iceland4 aut
7001 a Holm, M.u Sahlgrens Univ Hosp, Dept Occupat & Environm Med, Gothenburg, Sweden4 aut
7001 a Janson, Christeru Uppsala universitet,Lung- allergi- och sömnforskning4 aut0 (Swepub:uu)chrisjn
7001 a Jarvis, D.u Imperial Coll, Natl Heart & Lung Inst, Fac Med, London, England4 aut
7001 a Jõgi, R.4 aut
7001 a Kim, Jeong-Limu Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine,Univ Gothenburg, Sahlgrenska Acad, Dept Publ Hlth & Community Med, Occupat & Environm Med, Gothenburg, Sweden4 aut0 (Swepub:gu)xkimje
7001 a Kirkeleit, J.u Univ Bergen, Dept Global Publ Hlth & Primary Care, N-5021 Bergen, Norway4 aut
7001 a Lodge, C.u Univ Melbourne, Dept Populat Hlth, Melbourne, Vic, Australia4 aut
7001 a Malinovschi, Andrei,d 1978-u Uppsala universitet,Klinisk fysiologi4 aut0 (Swepub:uu)anmal535
7001 a Martinez-Moratalla, J.u CHUA, Serv Neurol, Serv Salud Castilla La Mancha SESCAM, Albacete, Spain4 aut
7001 a Nilsen, R. M.u Bergen Univ Coll, Dept Nursing, Bergen, Norway4 aut
7001 a Pereira-Vega, A.u Hosp Juan Ramon Jimenez, Pneumol Sect, Huelva, Spain4 aut
7001 a Real, F. G.u Univ Bergen, Dept Clin Sci, Bergen, Norway;Haukeland Hosp, Dept Obstet & Gynecol, Bergen, Norway4 aut
7001 a Schlünssen, V.u Aarhus Univ, Dept Publ Hlth, Aarhus, Denmark4 aut
7001 a Accordini, S.u Univ Verona, Dept Diagnost & Publ Hlth, Unit Epidemiol & Med Stat, Verona, Italy4 aut
7001 a Svanes, C.u Haukeland Hosp, Dept Occupat Med, Bergen, Norway;Univ Bergen, Dept Global Publ Hlth & Primary Care, Ctr Int Hlth, Bergen, Norway4 aut
7102 a Univ Bergen, Dept Global Publ Hlth & Primary Care, N-5021 Bergen, Norway;Haukeland Hosp, Dept Occupat Med, Bergen, Norwayb Univ Verona, Dept Diagnost & Publ Hlth, Unit Epidemiol & Med Stat, Verona, Italy4 org
7730 t Journal of Allergy and Clinical Immunologyd : Elsevier BVg 145:3q 145:3x 0091-6749x 1097-6825
8564 u http://www.jacionline.org/article/S0091674919311728/pdf
8564 u https://doi.org/10.1016/j.jaci.2019.08.030y Fulltext
8564 u https://umu.diva-portal.org/smash/get/diva2:1428498/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 u https://uu.diva-portal.org/smash/get/diva2:1433255/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 8u https://gup.ub.gu.se/publication/289671
8564 8u https://doi.org/10.1016/j.jaci.2019.08.030
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-170419
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-410139

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