Sökning: onr:"swepub:oai:gup.ub.gu.se/290684" > Associations betwee...
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000 | 05298naa a2200601 4500 | |
001 | oai:gup.ub.gu.se/290684 | |
003 | SwePub | |
008 | 240528s2019 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:142934439 | |
024 | 7 | a https://gup.ub.gu.se/publication/2906842 URI |
024 | 7 | a https://doi.org/10.1186/s12879-019-4682-z2 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1429344392 URI |
040 | a (SwePub)gud (SwePub)ki | |
041 | a eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Damlin, A.u Karolinska Institutet4 aut |
245 | 1 0 | a Associations between echocardiographic manifestations and bacterial species in patients with infective endocarditis: a cohort study |
264 | c 2019-12-16 | |
264 | 1 | b Springer Science and Business Media LLC,c 2019 |
520 | a Background: The diagnosis of infective endocarditis (IE) is based on microbiological analyses and diagnostic imaging of cardiac manifestations. Echocardiography (ECHO) is preferred for visualization of IE-induced cardiac manifestations. We investigated associations between bacterial infections and IE manifestations diagnosed by ECHO. Methods: In this cohort study, data from patients aged 18 years or above, with definite IE admitted at the Karolinska University Hospital between 2008 and 2017 were obtained from Swedish National Registry of Endocarditis. Bacteria registered as pathogen were primarily selected from positive blood culture and for patients with negative blood culture, bacteria found in culture or PCR from postoperative material was registered as pathogen. Patients with negative results from culture or PCR, and patients who did not undergo ECHO during hospital stay, were excluded. IE manifestations diagnosed by ECHO were obtained from the registry. Chi-squared test and two-sided Fisher's exact test was used for comparisons between categorical variables, and student's t test was used for continuous numerical variables. Multivariable analyses were performed using logistic regression. Secular trend analyses were performed using linear regression. Associations and the strength between the variables were estimated using odds ratios (ORs) with 95% confidence intervals (CIs). P < 0.05 was considered significant. Results: The most common bacteria were Staphylococcus aureus (n = 239, 49%) and viridans group streptococci (n = 102, 21%). The most common manifestations were vegetation in the mitral (n = 195, 40%), aortic (n = 190, 39%), and tricuspid valves (n = 108, 22%). Associations were seen between aortic valve vegetations and Enterococcus faecalis among patients with native aortic valves, between mitral valve vegetations and streptococci of group B or viridans group, between tricuspid valve vegetations and S. aureus among patients with intravenous drug abuse, and between perivalvular abscesses as well as cardiovascular implantable electronic device (CIED)-associated IE and coagulase negative staphylococci (all P < 0.05). Conclusions: Associations were found between certain bacterial species and specific ECHO manifestations. Our study contributes to a better understanding of IE manifestations and their underlying bacterial etiology, which pathogens can cause severe infections and might require close follow-up and surgical treatment. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Infektionsmedicin0 (SwePub)302092 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Infectious Medicine0 (SwePub)302092 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng |
653 | a Infective endocarditis | |
653 | a Echocardiography | |
653 | a Heart valves | |
653 | a Diagnostics | |
653 | a Cardiac imaging | |
653 | a health-care professionals | |
653 | a international collaboration | |
653 | a staphylococcus-aureus | |
653 | a antimicrobial therapy | |
653 | a management | |
653 | a diagnosis | |
653 | a complications | |
653 | a guidelines | |
653 | a statement | |
653 | a surgery | |
653 | a Infectious Diseases | |
700 | 1 | a Westling, K.u Karolinska Institutet4 aut |
700 | 1 | a Maret, E.u Karolinska Institutet4 aut |
700 | 1 | a Lundborg, C. S.u Karolinska Institutet4 aut |
700 | 1 | a Caidahl, Kenneth,d 1949u Karolinska Institutet,Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine4 aut0 (Swepub:gu)xcaike |
700 | 1 | a Eriksson, M. J.4 aut |
710 | 2 | a Karolinska Institutetb Institutionen för medicin, avdelningen för molekylär och klinisk medicin4 org |
773 | 0 | t BMC Infectious Diseasesd : Springer Science and Business Media LLCg 19q 19x 1471-2334 |
856 | 4 | u https://bmcinfectdis.biomedcentral.com/track/pdf/10.1186/s12879-019-4682-z |
856 | 4 8 | u https://gup.ub.gu.se/publication/290684 |
856 | 4 8 | u https://doi.org/10.1186/s12879-019-4682-z |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:142934439 |
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