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Potentiation of the...
Potentiation of the antihypertensive effect of enalapril by randomized addition of different doses of hydrochlorothiazide.
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- Dahlöf, Björn, 1953 (författare)
- Gothenburg University,Göteborgs universitet,Medicinska institutionen,Department medicine
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- Andrén, Lennart, 1946 (författare)
- Gothenburg University,Göteborgs universitet,Medicinska institutionen,Department medicine
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- Eggertsen, Robert, 1948 (författare)
- Gothenburg University,Göteborgs universitet,Medicinska institutionen,Department medicine
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visa fler...
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- Jern, Sverker, 1954 (författare)
- Gothenburg University,Göteborgs universitet,Medicinska institutionen,Department medicine
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- SVensson, Anders (författare)
- Gothenburg University,Göteborgs universitet,Medicinska institutionen,Department medicine
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- Hansson, Lennart (författare)
- Gothenburg University,Göteborgs universitet,Medicinska institutionen,Department medicine
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visa färre...
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(creator_code:org_t)
- 1985
- 1985
- Engelska.
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Ingår i: Journal of hypertension. Supplement : official journal of the International Society of Hypertension. - 0952-1178. ; 3:3
- Relaterad länk:
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https://gup.ub.gu.se...
Abstract
Ämnesord
Stäng
- The purpose of this study was to evaluate the potentiating effect of hydrochlorothiazide (HCTZ) 12.5 or 25 mg once daily when added in a placebo-controlled double-blind randomized study of patients with essential hypertension, whose diastolic blood pressure (DBP) was not adequately controlled (DBP > 90 mmHg) following 6 weeks of single-blind treatment with the angiotensin converting enzyme (ACE) inhibitor enalapril, 20 mg once daily. Forty-eight patients started the first period with enalapril after 4 weeks on placebo. In 13 patients DBP fell to < or = 90 mmHg after enalapril for 6 weeks. In this group supine mean arterial pressure (MAP) was reduced by 13% (P < 0.01). In the patients whose DBP was > 90 mmHg after 6 weeks on enalapril (n = 32) the average supine MAP fell by 9% (P < 0.001). After 3 weeks there was no further drop in blood pressure (BP). Addition of HCTZ to the 32 patients with DBP > 90 mmHg caused a significant further drop in supine BP by 13/7 mmHg with 12.5 mg and by 15/7 mmHg with 25 mg. Seven patients discontinued the study, none due to side effects on enalapril alone. Well-being, assessed with a special questionnaire, was significantly better with enalapril as monotherapy compared with previous treatment, but not different from well-being during the placebo periods. It is concluded that 20 mg enalapril once daily lowered BP effectively and was well tolerated. The maximum BP lowering effect was seen within 3 weeks. Addition of HCTZ caused a significant, and clinically relevant, further drop in BP.(ABSTRACT TRUNCATED AT 250 WORDS)
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Allmänmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- General Practice (hsv//eng)
Nyckelord
- Adult
- Double-Blind Method
- Drug Synergism
- Drug Therapy
- Combination
- Enalapril
- administration & dosage
- adverse effects
- therapeutic use
- Female
- Humans
- Hydrochlorothiazide
- administration & dosage
- adverse effects
- therapeutic use
- Hypertension
- drug therapy
- physiopathology
- psychology
- Male
- Middle Aged
- Single-Blind Method
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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