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Hitchhiking on vesi...
Hitchhiking on vesicles: a way to harness age-related proteopathies?
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- Ahmadpour, Doryaneh, 1973 (författare)
- Gothenburg University,Göteborgs universitet,Centrum för åldrande och hälsa (AgeCap),Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institutionen för biomedicin,Centre for Ageing and Health (Agecap),Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,Institute of Biomedicine,University of Gothenburg
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- Babazadeh, Roja (författare)
- Gothenburg University,Göteborgs universitet,Centrum för åldrande och hälsa (AgeCap),Institutionen för biomedicin,Centre for Ageing and Health (Agecap),Institute of Biomedicine,University of Gothenburg,Chalmers tekniska högskola,Chalmers University of Technology
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- Nyström, Thomas, 1960 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin,Centrum för åldrande och hälsa (AgeCap),Institute of Biomedicine,Centre for Ageing and Health (Agecap),University of Gothenburg
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(creator_code:org_t)
- 2020-05-10
- 2020
- Engelska.
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Ingår i: FEBS Journal. - : Wiley. - 1742-464X .- 1742-4658. ; 287:23, s. 5068-5079
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Abstract
Ämnesord
Stäng
- Central to proteopathies and leading to most age-related neurodegenerative disorders is a failure in protein quality control (PQC). To harness the toxicity of misfolded and damaged disease proteins, such proteins are either refolded, degraded by temporal PQC, or sequestered by spatial PQC into specific, organelle-associated, compartments within the cell. Here, we discuss the impact of vesicle trafficking pathways in general, and syntaxin 5 in particular, as key players in spatial PQC directing misfolded proteins to the surface of vacuole and mitochondria, which facilitates their clearance and detoxification. Since boosting vesicle trafficking genetically can positively impact on spatial PQC and make cells less sensitive to misfolded disease proteins, we speculate that regulators of such trafficking might serve as therapeutic targets for age-related neurological disorders.
Ämnesord
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Medicinsk bioteknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Medical Biotechnology (hsv//eng)
Nyckelord
- aggregate clearance
- aging
- inclusion body formation
- mitochondria
- neurodegenerative disorders
- organelle contact sites
- protein quality
- control
- syntaxin 5
- vacuole
- vesicle trafficking
- protein-quality control
- epidermal-growth-factor
- asymmetric
- inheritance
- damaged proteins
- axonal-transport
- molecular chaperones
- misfolded proteins
- endoplasmic-reticulum
- spatial sequestration
- vacuole function
- Biochemistry & Molecular Biology
- vesicle trafficking
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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