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Clinical relevance ...
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Martensson, T.Karolinska Institutet
(författare)
Clinical relevance of endoscopy with histopathological assessment in children with suspected gastrointestinal graft-versus-host disease
- Artikel/kapitelEngelska2020
Förlag, utgivningsår, omfång ...
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LIBRIS-ID:oai:gup.ub.gu.se/293708
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https://gup.ub.gu.se/publication/293708URI
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https://doi.org/10.1111/ctr.13867DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-423812URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:143599005URI
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Endoscopy with histopathological assessment is an established practice to confirm gastrointestinal graft-versus-host disease (GI-GVHD). However, the clinical relevance of this approach in children is incompletely evaluated. In a retrospective cohort study, we investigated the frequency of treatment changes in response to histopathological findings in all children (<18 years) in Sweden who underwent endoscopy for suspected GI-GVHD (2000-2013) after receiving hematopoietic stem cell transplantation. Sixty-eight children with ninety-one endoscopic occasions were enrolled. At the time of endoscopy, anti-GI-GVHD treatment was ongoing in 71% (65/91). In 18% (12/65) with ongoing treatment, no histopathological evidence of GI-GVHD or another cause to justify anti-GI-GVHD treatment was found. In 48% (44/91), endoscopy with histopathological assessment led to changes in the treatment regimen. Re-endoscopy was more frequent among those with treatment changes, versus unchanged treatment, 39% (17/44) and 13% (6/47), respectively (P = .007). Histopathological findings generating treatment changes were as follows: GI-GVHD in 68% (30/44), normal histology in 25% (11/44), and an alternative diagnosis in 7% (3/44). In conclusion, this study supports that endoscopy with histopathological assessment should be considered in all children with suspected GI-GVHD.
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Biuppslag (personer, institutioner, konferenser, titlar ...)
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Mellgren, Karin,1962Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Clinical Sciences, Department of Pediatrics,Univ Gothenburg, Sahlgrenska Acad, Inst Clin Sci, Dept Pediat, Gothenburg, Sweden.(Swepub:gu)xmellk
(författare)
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Toporski, J.Skane Univ Hosp, Dept Pediat, Lund, Sweden.
(författare)
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Arvidson, Johan,1953-Uppsala universitet,Barnneurologi/Barnonkologi(Swepub:uu)johanas
(författare)
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Szakos, A.Karolinska Univ Hosp, Dept Clin Pathol & Cytol, Stockholm, Sweden.
(författare)
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Casswall, T. H.Karolinska Institutet
(författare)
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Gustafsson, B.Karolinska Institutet
(författare)
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Karolinska InstitutetInstitutionen för kliniska vetenskaper, Avdelningen för pediatrik
(creator_code:org_t)
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Ingår i:Clinical Transplantation: Wiley34:70902-00631399-0012
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