Sökning: onr:"swepub:oai:gup.ub.gu.se/294353" > Chromosomal imbalan...
Fältnamn | Indikatorer | Metadata |
---|---|---|
000 | 03162naa a2200613 4500 | |
001 | oai:gup.ub.gu.se/294353 | |
003 | SwePub | |
008 | 240528s2009 | |||||||||||000 ||eng| | |
024 | 7 | a https://gup.ub.gu.se/publication/2943532 URI |
040 | a (SwePub)gu | |
041 | a eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Verdorfer, I.4 aut |
245 | 1 0 | a Chromosomal imbalances, 11q21 rearrangement and MECT1-MAML2 fusion transcript in mucoepidermoid carcinomas of the salivary gland. |
264 | 1 | c 2009 |
520 | a The aim of this study was to determine genetic alterations in mucoepidermoid carcinomas of the salivary gland in association with clinical and histopathological parameters. Nineteen formalin-fixed, paraffin-embedded tumors were analysed by using comparative genomic hybridization (CGH), fluorescence in situ hybridization (FISH) on interphase nuclei and reverse transcriptase-polymerase chain reaction (RT-PCR) for detection of MECT1-MAML2 fusion transcript. The CGH analysis showed an overrepresentation of chromosome X and losses of entire chromosomes or regions on chromosome 1, 2, and 15 as the most frequent copy number changes. In 37% of the analysed tumors a MAML2-rearrangement by interphase FISH was detected, whereas 58% of the samples showed expression of MECT1-MAML2 fusion transcript. We conclude that the presence of MAML2-rearrangement as well as of MECT1-MAML2 fusion transcript may reflect a more favourable prognosis and may be a useful marker for clinical prediction of the biological behavior of these tumors as previously reported. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng |
653 | a Adult | |
653 | a Aged | |
653 | a Aged | |
653 | a 80 and over | |
653 | a Carcinoma | |
653 | a Mucoepidermoid | |
653 | a genetics | |
653 | a Chromosome Aberrations | |
653 | a Chromosomes | |
653 | a Human | |
653 | a Pair 11 | |
653 | a Humans | |
653 | a Male | |
653 | a Middle Aged | |
653 | a Oncogene Proteins | |
653 | a Fusion | |
653 | a genetics | |
653 | a RNA | |
653 | a Messenger | |
653 | a analysis | |
653 | a Salivary Gland Neoplasms | |
653 | a genetics | |
700 | 1 | a Fehr, Andreu Gothenburg University,Göteborgs universitet,Institutionen för biomedicin,Institutionen för biomedicin, avdelningen för patologi,Institute of Biomedicine,Institute of Biomedicine, Department of Pathology4 aut0 (Swepub:gu)xfehra |
700 | 1 | a Bullerdiek, J.4 aut |
700 | 1 | a Scholz, N.4 aut |
700 | 1 | a Brunner, A.4 aut |
700 | 1 | a Krugmann, J.4 aut |
700 | 1 | a Hager, M.4 aut |
700 | 1 | a Haufe, H.4 aut |
700 | 1 | a Mikuz, G.4 aut |
700 | 1 | a Scholtz, A.4 aut |
710 | 2 | a Göteborgs universitetb Institutionen för biomedicin4 org |
773 | 0 | t Oncology reportsg 22:2, s. 305-11q 22:2<305-11x 1021-335X |
856 | 4 8 | u https://gup.ub.gu.se/publication/294353 |
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