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Laparoscopic roux-e...
Laparoscopic roux-en-Y gastric bypass versus sleeve gastrectomy for teenagers with severe obesity-TEEN-BEST: study protocol of a multicenter randomized controlled trial
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- Bonouvrie, D. S. (författare)
- Maxima Med Ctr, Netherlands
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- Beamish, Andrew J. (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för gastrokirurgisk forskning och utbildning,Institute of Clinical Sciences, Department of Gastrosurgical Research and Education,Gothenburg Univ, Sweden; Royal Coll Surgeons England, England
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- Leclercq, W. K. G. (författare)
- Maxima Med Ctr, Netherlands
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van Mil, Egah (författare)
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- Luijten, Aapm (författare)
- Maxima Med Ctr, Netherlands
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- Hazebroek, E. J. (författare)
- Rijnstate Hosp, Netherlands
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- Vreugdenhil, A. C. E. (författare)
- Maastricht Univ, Netherlands
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- Olbers, Torsten (författare)
- Linköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Region Östergötland, Kirurgiska kliniken ViN
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- van Dielen, F. M. H. (författare)
- Maxima Med Ctr, Netherlands
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- van Mil, Edgar G. A. H. (författare)
- Jeroen Bosch Hosp, Netherlands
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(creator_code:org_t)
- 2020-06-03
- 2020
- Engelska.
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Ingår i: Bmc Surgery. - : Springer Science and Business Media LLC. - 1471-2482. ; 20:1
- Relaterad länk:
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https://bmcsurg.biom...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Background Recent data support the use of bariatric surgery in adolescents with severe obesity following unsuccessful non-surgical treatments. Sleeve gastrectomy (SG) and Roux-en-Y gastric bypass (RYGB) have demonstrated reasonably similar weight loss and reduction of obesity related comorbidities in randomized trials in adults. SG has internationally become the most commonly used procedure in adolescents, yet long-term outcome data are lacking. No randomized controlled trial comparing SG and RYGB has been performed in adolescents. Objective Determine whether SG is non-inferior to RYGB in terms of total body weight (TBW) loss in adolescents with severe obesity. Methods A multicenter randomized controlled non-inferiority trial. Two hundred sixty-four adolescents aged 13-17 (Tanner stage >= IV) with severe obesity (corrected for age and sex) will be included. Adolescents agreeing to participate will be randomized to either RYGB or SG. The primary outcome is the proportion of participants achieving 20% TBW loss at 3 years postoperatively. Secondary outcomes include (i) change in body weight, body mass index (BMI) and BMI standard deviation score, (ii) incidence of adverse health events and need for additional surgical intervention, (iii) resolution of obesity-related comorbidities, (iv) prevalence of cardio metabolic risk factor measures, (v) bone health measures and incidence of bone fractures, (vi) quality of life including psychosocial health, patient satisfaction and educational attainment and (vii) body composition. Follow-up will extend into the long term. Results Not applicable. Discussion This study will, to our knowledge, be the first randomized controlled trial comparing SG and RYGB in adolescents with severe obesity.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
Nyckelord
- Adolescents
- Bariatric surgery
- Sleeve gastrectomy
- Roux-en-Y gastric
- bypass
- Severe obesity
- bariatric surgery
- united-states
- children
- adolescents
- Surgery
- Adolescents; Bariatric surgery; Sleeve gastrectomy; Roux-en-Y gastric bypass; Severe obesity
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Bonouvrie, D. S.
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Beamish, Andrew ...
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Leclercq, W. K. ...
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van Mil, Egah
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Luijten, Aapm
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Hazebroek, E. J.
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visa fler...
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Vreugdenhil, A. ...
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Olbers, Torsten
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van Dielen, F. M ...
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van Mil, Edgar G ...
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Gastroenterologi
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Pediatrik
- Artiklar i publikationen
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Bmc Surgery
- Av lärosätet
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Göteborgs universitet
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Linköpings universitet