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Urine 6-Bromotrypto...
Urine 6-Bromotryptophan: Associations with Genetic Variants and Incident End-Stage Kidney Disease
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Sekula, P. (författare)
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Tin, A. (författare)
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Schultheiss, U. T. (författare)
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- Baid-Agrawal, Seema, 1966 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine
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Mohney, R. P. (författare)
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Steinbrenner, I. (författare)
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Yu, B. (författare)
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Luo, S. Y. (författare)
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Boerwinkle, E. (författare)
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Eckardt, K. U. (författare)
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Coresh, J. (författare)
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Grams, M. E. (författare)
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Kottgen, A. (författare)
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(creator_code:org_t)
- 2020-06-22
- 2020
- Engelska.
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Ingår i: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 10:1
- Relaterad länk:
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https://www.nature.c...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Higher serum 6-bromotryptophan has been associated with lower risk of chronic kidney disease (CKD) progression, implicating mechanisms beyond renal clearance. We studied genetic determinants of urine 6-bromotryptophan and its association with CKD risk factors and incident end-stage kidney disease (ESKD) in 4,843 participants of the German Chronic Kidney Disease (GCKD) study. 6-bromotryptophan was measured from urine samples using mass spectrometry. Patients with higher levels of urine 6-bromotryptophan had higher baseline estimated glomerular filtration rate (eGFR, p<0.001). A genome-wide association study of urine 6-bromotryptophan identified two significant loci possibly related to its tubular reabsorption, SLC6A19, and its production, ERO1A, which was also associated with serum 6-bromotryptophan in an independent study. The association between urine 6-bromotryptophan and time to ESKD was assessed using Cox regression. There were 216 ESKD events after four years of follow-up. Compared with patients with undetectable levels, higher 6-bromotryptophan levels were associated with lower risk of ESKD in models unadjusted and adjusted for ESKD risk factors other than eGFR (= median level: HR 0.50, 95% CI 0.34 to 0.74). Upon adjustment for baseline eGFR, this association became attenuated, suggesting that urine 6-bromotryptophan may represent a correlated marker of kidney health.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
Nyckelord
- genome-wide association
- risk
- bromination
- model
- gckd
- Science & Technology - Other Topics
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Sekula, P.
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Tin, A.
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Schultheiss, U. ...
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Baid-Agrawal, Se ...
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Mohney, R. P.
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Steinbrenner, I.
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visa fler...
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Yu, B.
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Luo, S. Y.
-
Boerwinkle, E.
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Eckardt, K. U.
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Coresh, J.
-
Grams, M. E.
-
Kottgen, A.
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Urologi och njur ...
- Artiklar i publikationen
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Scientific Repor ...
- Av lärosätet
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Göteborgs universitet