Sökning: onr:"swepub:oai:gup.ub.gu.se/294971" >
Animal Models to Un...
Animal Models to Understand the Etiology and Pathophysiology of Polycystic Ovary Syndrome
-
- Stener-Victorin, E. (författare)
- Karolinska Institutet
-
- Padmanabhan, V. (författare)
- Departments of Pediatrics, Obstetrics and Gynecology, and Environmental Health Sciences, University of Michigan, Ann Arbor, USA
-
- Walters, K. A. (författare)
- Fertility & Research Centre, School of Women's and Children's Health, University of New South Wales, Sydney, Australia
-
visa fler...
-
- Campbell, R. E. (författare)
- Centre for Neuroendocrinology and Department of Physiology, School of Biomedical Sciences, University of Otago, Dunedin, New Zealand
-
- Benrick, Anna, 1979 (författare)
- Högskolan i Skövde,Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology,Institutionen för hälsovetenskaper,Forskningsmiljön hälsa, hållbarhet och digitalisering,Department of Physiology, Sahlgrenska Academy, University of Gothenburg, Sweden,Translationell medicin TRIM, Translational Medicine
-
- Giacobini, P. (författare)
- University of Lille, Inserm, CHU Lille, U1172 - LilNCog - Lille Neuroscience & Cognition, France
-
- Dumesic, D. A. (författare)
- Department of Obstetrics and Gynecology, David Geffen School of Medicine, University of California, USA
-
- Abbott, D. H. (författare)
- Department of Obstetrics and Gynecology, Wisconsin National Primate Research Center, University of Wisconsin, Madison, USA
-
visa färre...
-
(creator_code:org_t)
- 2020-04-20
- 2020
- Engelska.
-
Ingår i: Endocrine Reviews. - : The Endocrine Society. - 0163-769X .- 1945-7189. ; 41:4
- Relaterad länk:
-
https://doi.org/10.1...
-
visa fler...
-
https://doi.org/10.1...
-
https://his.diva-por... (primary) (Raw object)
-
https://gup.ub.gu.se...
-
https://doi.org/10.1...
-
https://urn.kb.se/re...
-
http://kipublication...
-
visa färre...
Abstract
Ämnesord
Stäng
- More than 1 out of 10 women worldwide are diagnosed with polycystic ovary syndrome (PCOS), the leading cause of female reproductive and metabolic dysfunction. Despite its high prevalence, PCOS and its accompanying morbidities are likely underdiagnosed, averaging > 2 years and 3 physicians before women are diagnosed. Although it has been intensively researched, the underlying cause(s) of PCOS have yet to be defined. In order to understand PCOS pathophysiology, its developmental origins, and how to predict and prevent PCOS onset, there is an urgent need for safe and effective markers and treatments. In this review, we detail which animal models are more suitable for contributing to our understanding of the etiology and pathophysiology of PCOS. We summarize and highlight advantages and limitations of hormonal or genetic manipulation of animal models, as well as of naturally occurring PCOS-like females.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Fysiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Physiology (hsv//eng)
Nyckelord
- androgen excess
- developmental programming
- genetic manipulation
- therapeutic prevention
- adipogenic constraint-induced lipotoxicity
- naturally hyperandrogenic female monkeys
- anti-mullerian hormone
- prenatal testosterone excess
- female
- rhesus-monkeys
- developmental programming impact
- reproductive
- neuroendocrine function
- nerve growth-factor
- low-dose
- dihydrotestosterone
- green fluorescent protein
- receptor
- gene-expression
- genome-wide association
- Endocrinology & Metabolism
- adipogenic constraint-induced lipotoxicity
- Translationell medicin TRIM
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas