Sökning: onr:"swepub:oai:gup.ub.gu.se/295171" >
Fractional flow res...
Fractional flow reserve-guided multivessel angioplasty in myocardial infarction: three-year follow-up with cost benefit analysis of the Compare-Acute trial
-
Smits, P. C. (författare)
-
Laforgia, P. L. (författare)
-
Abdel-Wahab, M. (författare)
-
visa fler...
-
Neumann, F. J. (författare)
-
Richardt, G. (författare)
-
Boxma-de Klerk, B. (författare)
-
Lunde, K. (författare)
-
Schotborgh, C. E. (författare)
-
Piroth, Z. (författare)
-
Horak, D. (författare)
-
Wlodarczak, A. (författare)
-
Frederix, G. W. (författare)
-
- Omerovic, Elmir, 1968 (författare)
- Gothenburg University,Göteborgs universitet,Center for Cardiovascular and Metabolic Research (CMR)
-
visa färre...
-
(creator_code:org_t)
- Europa Digital & Publishing, 2020
- 2020
- Engelska.
-
Ingår i: Eurointervention. - : Europa Digital & Publishing. - 1774-024X. ; 16:3, s. 225-232
- Relaterad länk:
-
https://gup.ub.gu.se...
-
visa fler...
-
https://doi.org/10.4...
-
visa färre...
Abstract
Ämnesord
Stäng
- Aims: The Compare-Acute trial showed superiority of fractional flow reserve (FFR)-guided acute complete revascularisation compared to culprit-only treatment in patients with ST-segment elevation myocardial infarction (STEMI) and multivessel disease (MVD) at one year. The aim of this study was to investigate the outcome at three years, together with cost analysis of this strategy. Methods and results: After primary percutaneous coronary intervention (PCI), 885 patients with STEMI and MVD were randomised (1:2 ratio) to FFR-guided complete revascularisation (295 patients) or infarct-related artery (IRA)-only treatment (590 patients). After 36 months, the primary endpoint (composite of death, myocardial infarction, revascularisation, stroke) occurred significantly less frequently in the FFR-guided complete revascularisation group: 46/295 patients (15.6%) versus 178/590 patients (30.2%) (HR 0.46, 95% CI: 0.33-0.64; p<0.001). This benefit was driven mainly by the reduction of revascularisations in the follow-up (12.5% vs 25.2%; HR 0.45, 95% CI: 0.31-0.64; p<0.001). Cost analysis shows benefit of the FFR-guided complete revascularisation strategy, which can reduce the cost per patient by up to 21% at one year (8,150(sic) vs 10,319(sic)) and by 22% at three years (8,653(sic) vs 11,100(sic)). Conclusions: In patients with STEMI and MVD, FFR-guided complete revascularisation is more beneficial in terms of outcome and healthcare costs compared to IRA-only revascularisation at 36 months.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- clinical trials
- fractional flow reserve
- multiple vessel disease
- STEMI
- percutaneous coronary intervention
- st-segment elevation
- randomized-trial
- revascularization
- disease
- lesion
- Cardiovascular System & Cardiology
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Smits, P. C.
-
Laforgia, P. L.
-
Abdel-Wahab, M.
-
Neumann, F. J.
-
Richardt, G.
-
Boxma-de Klerk, ...
-
visa fler...
-
Lunde, K.
-
Schotborgh, C. E ...
-
Piroth, Z.
-
Horak, D.
-
Wlodarczak, A.
-
Frederix, G. W.
-
Omerovic, Elmir, ...
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Kardiologi
- Artiklar i publikationen
-
Eurointervention
- Av lärosätet
-
Göteborgs universitet