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Validation of WINRO...
Validation of WINROP (online prediction model) to identify severe retinopathy of prematurity (ROP) in an Australian preterm population: a retrospective study
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- Desai, S. (författare)
- Department of Neonatology, Perth Children’s Hospital, Perth WA, Australia; Department of Neonatology, King Edward Memorial Hospital for Women, Perth WA, Australia
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- Athikarisamy, S. E. (författare)
- Department of Neonatology, Perth Children’s Hospital, Perth WA, Australia; Department of Neonatology, King Edward Memorial Hospital for Women, Perth WA, Australia; Department of Paediatrics, University of Western Australia, Crawley WA, Australia
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- Lundgren, Pia, 1967 (författare)
- Örebro universitet,Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
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- Simmer, K. (författare)
- Department of Neonatology, Perth Children’s Hospital, Perth WA, Australia; Department of Neonatology, King Edward Memorial Hospital for Women, Perth WA, Australia; Department of Paediatrics, University of Western Australia, Crawley WA, Australia
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- Lam, G. C. (författare)
- Department of Ophthalmology, Perth Children’s Hospital, Perth WA, Australia; Centre for Ophthalmology and Visual Science, University of Western Australia, Crawley WA, Australia
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(creator_code:org_t)
- 2020-07-17
- 2021
- Engelska.
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Ingår i: Eye. - : Springer Science and Business Media LLC. - 0950-222X .- 1476-5454. ; 35, s. 1334-1339
- Relaterad länk:
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
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- Introduction Retinopathy of prematurity (ROP) is the most common disease leading to blindness in extreme preterm infants. Current screening guidelines recommend frequent eye examinations. There is a dearth of trained ophthalmologists for these frequent screening procedures. The ANZNN neonatal network report (2013) found that only 6.4% of all screened infants had severe ROP and less than half received treatment. WINROP (online prediction model, Sweden) uses the postnatal weight gain (surrogate marker for low insulin-like growth factor IGF-1 and poor retinal vascular growth) to identify ROP requiring treatment and aims to reduce the number of examinations. Our objective was to validate the WINROP model in an Australian cohort of preterm infants. Methods Birth weight, gestational age, and weekly weight measurements were retrieved retrospectively along with the final ROP outcomes and plotted on the online WINROP software. Results The sensitivity, specificity, positive predictive value, and negative predictive value of WINROP were 85.7%, 59.0%, 6.98%, and 99.1% respectively for a cohort of 221 preterm infants (Median birth weight, 1040 g; Gestational age, 27.9 weeks). WINROP alarm was signaled in 42.6% of all infants. WINROP did not signal an alarm in one infant who needed treatment. This infant had intra ventricular hemorrhage grade 3-4 and temporary ventricular dilatation. Conclusions This is the first Australian study validating WINROP model. Our findings suggest that it lacked sensitivity to be used alone. However, adjusting the algorithm for the Australian population may improve the efficacy and reduce the number of examinations when used along with the current screening guidelines.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Oftalmologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Ophthalmology (hsv//eng)
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