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Baseline Results: T...
Baseline Results: The Association between Cardiovascular Risk and Preclinical Alzheimer's Disease Pathology (ASCEND) Study
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Kumar, V. V. (författare)
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Huang, H. (författare)
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Zhao, L. (författare)
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visa fler...
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Verble, D. D. (författare)
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Nutaitis, A. (författare)
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Tharwani, S. D. (författare)
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Brown, A. L. (författare)
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- Zetterberg, Henrik, 1973 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Hu, W. (författare)
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Shin, R. (författare)
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Kehoe, P. G. (författare)
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Quyyumi, A. (författare)
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Nocera, J. (författare)
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Kippels, A. (författare)
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Wharton, W. (författare)
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(creator_code:org_t)
- 2020
- 2020
- Engelska.
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Ingår i: Journal of Alzheimer's Disease. - 1387-2877. ; 75:1, s. 109-117
- Relaterad länk:
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https://gup.ub.gu.se...
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- Background: The rate of AD for African Americans (AAs) is 64% higher than for non-Hispanic White Americans (Whites). It is hypothesized that poor peripheral vascular function, in combination with genetics, stress, and inflammation may directly contribute to the accumulation of AD pathologic biomarkers. These risk factors may disproportionately affect AAs. Objective: Our objective was to determine if in a healthy middle-aged cohort at risk for AD (1) AD biomarkers in CSF differ by race, (2) peripheral vascular dysfunction and cognition are related to a higher burden of CSF AD biomarkers, and (3) these relationships differ by race. Methods: We enrolled 82 cognitively normal, middle-aged (45 and older) adults including AAs and Whites at high risk for AD due to parental history. Study procedures included lumbar puncture, vascular ultrasound, and cognitive testing. Results: While participants were in overall good health, AAs exhibited poorer indices of preclinical vascular health, including higher central SBP, central MAP, and EndoPAT AI, a marker of arterial stiffness. AAs also had significantly less cerebrospinal fluid tau burden than Whites. After polynomial regression analysis, adjusted for age, gender, education, and ApoE4 status, race significantly modified the relationship between total tau, phospho-tau, and Trails B, a marker of executive function. Small differences in tau correlated with poorer cognition in AAs. Conclusion: In a healthy middle-aged cohort at risk for AD, AAs had worse peripheral vascular health and worse cognition than Whites. Despite lower tau burden overall, race modified the relationship between tau and cognition, such that small differences in tau between AAs was related to worse cognition when compared to Whites. © 2020 - IOS Press and the authors. All rights reserved.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
Nyckelord
- Alzheimer's disease
- cognition
- hypertension
- parental history
- prevention
- tau
- vascular risk
- apolipoprotein E4
- biological marker
- adult
- African American
- aged
- Alzheimer disease
- arterial stiffness
- Article
- cardiovascular risk
- Caucasian
- cerebrospinal fluid
- cohort analysis
- disease association
- executive function
- female
- follow up
- human
- longitudinal study
- lumbar puncture
- major clinical study
- male
- middle aged
- neuropathology
- observational study
- peripheral vascular disease
- priority journal
- race difference
- risk factor
- task performance
- ultrasound
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Kumar, V. V.
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Huang, H.
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Zhao, L.
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Verble, D. D.
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Nutaitis, A.
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Tharwani, S. D.
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visa fler...
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Brown, A. L.
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Zetterberg, Henr ...
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Hu, W.
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Shin, R.
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Kehoe, P. G.
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Quyyumi, A.
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Nocera, J.
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Kippels, A.
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Wharton, W.
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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och Neurovetenskaper
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Psykiatri
- Artiklar i publikationen
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Journal of Alzhe ...
- Av lärosätet
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Göteborgs universitet