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Lasting Gammaproteo...
Lasting Gammaproteobacteria profile changes characterized hematological cancer patients who developed oral mucositis following conditioning therapy
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Mougeot, J. L. C. (författare)
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Beckman, M. F. (författare)
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Stevens, C. B. (författare)
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Almon, K. G. (författare)
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Morton, D. S. (författare)
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- von Bültzingslöwen, Inger, 1947 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för odontologi,Institute of Odontology
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Brennan, M. T. (författare)
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Mougeot, F. B. (författare)
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(creator_code:org_t)
- 2020-05-13
- 2020
- Engelska.
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Ingår i: Journal of Oral Microbiology. - : Informa UK Limited. - 2000-2297. ; 12:1
- Relaterad länk:
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https://www.tandfonl...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background: Oral mucositis (OM) is a common side effect of conditioning therapy implemented before hematopoietic stem cell transplantation (HSCT). The role of oral microbiome in OM is not fully elucidated. Objective: To determine oral microbiome profile changes post-conditioning in HSCT patients who developed moderate OM, or mild to no OM. Design: Patient groups were: Muc0-1 with OM-score = 0-1 (43 paired samples) and Muc2 with WHO OM-score = 2 (36 paired samples). Bacterial DNA was isolated from oral samples (saliva, swabs of buccal mucosa, tongue, and supragingival plaque) at pre-conditioning (T-0), post-conditioning mucositis onset (T-Muc), and one-year post-conditioning (T-Year). 16S-rRNA gene next-generation sequencing was used to determine the relative abundance (RA) of >700 oral species. Alpha-diversity, beta-diversity and linear discriminant analyses (LDA) were performed Muc2 versus Muc0-1. Results: Muc2 oral microbiome alpha- and beta-diversity differed between T-0 and T-Muc. Muc2 alpha-diversity and Muc0-1 beta-diversity did not differ between T-0 and T-Year. T-0 to T-Muc LDA scores were significant in Muc2 for Gammaproteobacteria. For Muc2 patients, the average RA decreased for Haemophilus parainfluenza, a species known as mucosal surfaces protector, but increased for Escherichia-Shigella genera. Conclusions: Post-conditioning OM might contribute to long-term oral microbiome changes affecting Gammaproteobacteria, in HSCT patients.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- Mucosal immunity
- cancer biology
- bacteria
- hematopoietic stem cell
- transplantation
- transplantation conditioning
- hematologic neoplasms
- microbiome
- neck
- head
- impact
- costs
- risk
- Microbiology
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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