Sökning: onr:"swepub:oai:gup.ub.gu.se/296937" > Androgens in men st...
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000 | 07824naa a2200949 4500 | |
001 | oai:gup.ub.gu.se/296937 | |
003 | SwePub | |
008 | 240528s2020 | |||||||||||000 ||eng| | |
009 | oai:lup.lub.lu.se:d0cf0da8-5c1b-4b21-8f21-2de7375274ed | |
024 | 7 | a https://gup.ub.gu.se/publication/2969372 URI |
024 | 7 | a https://doi.org/10.1136/bmjopen-2019-0347772 DOI |
024 | 7 | a https://lup.lub.lu.se/record/d0cf0da8-5c1b-4b21-8f21-2de7375274ed2 URI |
040 | a (SwePub)gud (SwePub)lu | |
041 | a eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Yeap, B. B.u University of Western Australia, Crawley4 aut |
245 | 1 0 | a Androgens in men study (AIMS): Protocol for meta-analyses of individual participant data investigating associations of androgens with health outcomes in men |
264 | c 2020-05-11 | |
264 | 1 | b BMJ,c 2020 |
520 | a Introduction This study aims to clarify the role(s) of endogenous sex hormones to influence health outcomes in men, specifically to define the associations of plasma testosterone with incidence of cardiovascular events, cancer, dementia and mortality risk, and to identify factors predicting testosterone concentrations. Data will be accrued from at least three Australian, two European and four North American population-based cohorts involving approximately 20 000 men. Methods and analysis Eligible studies include prospective cohort studies with baseline testosterone concentrations measured using mass spectrometry and 5 years of follow-up data on incident cardiovascular events, mortality, cancer diagnoses or deaths, new-onset dementia or decline in cognitive function recorded. Data for men, who were not taking androgens or drugs suppressing testosterone production, metabolism or action; and had no prior orchidectomy, are eligible. Systematic literature searches were conducted from 14 June 2019 to 31 December 2019, with no date range set for searches. Aggregate level data will be sought where individual participant data (IPD) are not available. One-stage IPD random-effects meta-analyses will be performed, using linear mixed models, generalised linear mixed models and either stratified or frailty-augmented Cox regression models. Heterogeneity in estimates from different studies will be quantified and bias investigated using funnel plots. Effect size estimates will be presented in forest plots and non-negligible heterogeneity and bias investigated using subgroup or meta-regression analyses. Ethics and dissemination Ethics approvals obtained for each of the participating cohorts state that participants have consented to have their data collected and used for research purposes. The Androgens In Men Study has been assessed as exempt from ethics review by the Human Ethics office at the University of Western Australia (file reference number RA/4/20/5014). Each of the component studies had obtained ethics approvals; please refer to respective component studies for details. Research findings will be disseminated to the scientific and broader community via the publication of four research articles, with each involving a separate set of IPD meta-analyses (articles will investigate different, distinct outcomes), at scientific conferences and meetings of relevant professional societies. Collaborating cohort studies will disseminate findings to study participants and local communities. PROSPERO registration number CRD42019139668. © Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY. Published by BMJ. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi0 (SwePub)303022 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Public Health, Global Health, Social Medicine and Epidemiology0 (SwePub)303022 hsv//eng |
653 | a epidemiology | |
653 | a general endocrinology | |
653 | a sex steroids & HRT | |
653 | a androgen | |
653 | a androstanolone | |
653 | a estradiol | |
653 | a luteinizing hormone | |
653 | a sex hormone binding globulin | |
653 | a testosterone | |
653 | a Article | |
653 | a clinical outcome | |
653 | a clinical protocol | |
653 | a cognitive defect | |
653 | a dementia | |
653 | a disease association | |
653 | a follow up | |
653 | a frailty | |
653 | a human | |
653 | a malignant neoplasm | |
653 | a mass spectrometry | |
653 | a men's health | |
653 | a meta analysis | |
653 | a reference value | |
653 | a systematic review | |
653 | a testosterone metabolism | |
653 | a testosterone synthesis | |
700 | 1 | a Marriott, R. J.u University of Western Australia, Crawley4 aut |
700 | 1 | a Adams, R. J.u Flinders University4 aut |
700 | 1 | a Antonio, L.u Catholic University of Leuven4 aut |
700 | 1 | a Ballantyne, C. M.u Baylor College of Medicine4 aut |
700 | 1 | a Bhasin, S.u Harvard Medical School4 aut |
700 | 1 | a Cawthon, P. M.u California Pacific Medical Center4 aut |
700 | 1 | a Couper, D. J.u University of North Carolina4 aut |
700 | 1 | a Dobs, A. S.u Johns Hopkins University4 aut |
700 | 1 | a Flicker, L.u University of Western Australia, Crawley4 aut |
700 | 1 | a Karlsson, Magnusu Lund University,Lunds universitet,Ortopedi - klinisk och molekylär osteoporosforskning,Forskargrupper vid Lunds universitet,Orthopedics - Clinical and Molecular Osteoporosis Research,Lund University Research Groups4 aut0 (Swepub:lu)orto-mka |
700 | 1 | a Martin, S. A.u University of Adelaide4 aut |
700 | 1 | a Matsumoto, A. M.u VA Puget Sound Health Care System,Washington University School of Medicine4 aut |
700 | 1 | a Mellström, Dan,d 1945u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Centre for Bone and Arthritis Research,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition,Sahlgrenska Academy4 aut0 (Swepub:gu)xmelda |
700 | 1 | a Norman, P. E.u University of Western Australia, Crawley4 aut |
700 | 1 | a Ohlsson, Claes,d 1965u Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition,Sahlgrenska Academy4 aut0 (Swepub:gu)xohlcl |
700 | 1 | a Orwoll, E. S.u Oregon Health & Science University4 aut |
700 | 1 | a O'Neill, T. W.u University of Manchester,Manchester University NHS Foundation Trust4 aut |
700 | 1 | a Shores, M. M.u Washington University School of Medicine,VA Puget Sound Health Care System4 aut |
700 | 1 | a Travison, T. G.u Beth Israel Deaconess Medical Center,Harvard Medical School4 aut |
700 | 1 | a Vanderschueren, D.u Catholic University of Leuven4 aut |
700 | 1 | a Wittert, G. A.u University of Adelaide4 aut |
700 | 1 | a Wu, F. C. W.u University of Manchester4 aut |
700 | 1 | a Murray, K.u University of Western Australia, Crawley4 aut |
710 | 2 | a University of Western Australia, Crawleyb Flinders University4 org |
773 | 0 | t BMJ Opend : BMJg 10:5q 10:5x 2044-6055 |
856 | 4 | u https://bmjopen.bmj.com/content/bmjopen/10/5/e034777.full.pdf |
856 | 4 | u http://dx.doi.org/10.1136/bmjopen-2019-034777x freey FULLTEXT |
856 | 4 8 | u https://gup.ub.gu.se/publication/296937 |
856 | 4 8 | u https://doi.org/10.1136/bmjopen-2019-034777 |
856 | 4 8 | u https://lup.lub.lu.se/record/d0cf0da8-5c1b-4b21-8f21-2de7375274ed |
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