Meta-analysis of the gut microbiota in predicting response to cancer immunotherapy in metastatic melanoma.

Limeta, Angelo,1996Chalmers tekniska högskola,Chalmers University of Technology (författare)

BACKGROUNDIdentifying factors conferring responses to therapy in cancer is critical to select the best treatment for patients. For immune checkpoint inhibition (ICI) therapy, mounting evidence suggests that the gut microbiome can determine patient treatment outcomes. However, the extent to which gut microbial features are applicable across different patient cohorts has not been extensively explored.METHODSWe performed a meta-analysis of 4 published shotgun metagenomic studies (Ntot = 130 patients) investigating differential microbiome composition and imputed metabolic function between responders and nonresponders to ICI.RESULTSOur analysis identified both known microbial features enriched in responders, such as Faecalibacterium as the prevailing taxa, as well as additional features, including overrepresentation of Barnesiella intestinihominis and the components of vitamin B metabolism. A classifier designed to predict responders based on these features identified responders in an independent cohort of 27 patients with the area under the receiver operating characteristic curve of 0.625 (95% CI: 0.348-0.899) and was predictive of prognosis (HR = 0.35, P = 0.081).CONCLUSIONThese results suggest the existence of a fecal microbiome signature inherent across responders that may be exploited for diagnostic or therapeutic purposes.FUNDINGThis work was funded by the Knut and Alice Wallenberg Foundation, BioGaia AB, and Cancerfonden.

Ji, Boyang,1983Danmarks Tekniske Universitet,Technical University of Denmark,Chalmers tekniska högskola,Chalmers University of Technology(Swepub:cth)bojand (författare)
Levin, Max,1969Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Institutionen för kliniska vetenskaper, Avdelningen för onkologi,Wallenberg Laboratory,Institute of Clinical Sciences, Department of Oncology,Sahlgrenska universitetssjukhuset,Sahlgrenska University Hospital,University of Gothenburg(Swepub:gu)xlevma (författare)
Gatto, Francesco,1987Chalmers tekniska högskola,Chalmers University of Technology(Swepub:cth)gatto (författare)
Nielsen, Jens B,1962Chalmers tekniska högskola,Chalmers University of Technology,BioInnovation Institute (BII),Danmarks Tekniske Universitet,Technical University of Denmark(Swepub:cth)nielsenj (författare)
Chalmers tekniska högskolaDanmarks Tekniske Universitet (creator_code:org_t)

Av författaren/redakt...: Limeta, Angelo, ...; Ji, Boyang, 1983; Levin, Max, 1969; Gatto, Francesco ...; Nielsen, Jens B, ...

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