Sökning: onr:"swepub:oai:gup.ub.gu.se/299424" > Value of flow cytom...
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001 | oai:gup.ub.gu.se/299424 | |
003 | SwePub | |
008 | 240528s2021 | |||||||||||000 ||eng| | |
009 | oai:DiVA.org:umu-178333 | |
009 | oai:lup.lub.lu.se:7bab7e42-4df7-4f74-8d4f-140962a25921 | |
009 | oai:DiVA.org:uu-454517 | |
024 | 7 | a https://gup.ub.gu.se/publication/2994242 URI |
024 | 7 | a https://doi.org/10.1038/s41375-020-01100-52 DOI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1783332 URI |
024 | 7 | a https://lup.lub.lu.se/record/7bab7e42-4df7-4f74-8d4f-140962a259212 URI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4545172 URI |
040 | a (SwePub)gud (SwePub)umud (SwePub)lud (SwePub)uu | |
041 | a eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Modvig, Su Copenhagen University Hospital,Vilnius University,Copenhagen Univ Hosp, Rigshosp, Dept Clin Immunol, Copenhagen, Denmark.,Vilnius Univ Hosp, Santaros Klin, Hematol Oncol & Transfus Med Ctr, Vilnius, Lithuania.4 aut |
245 | 1 0 | a Value of flow cytometry for MRD-based relapse prediction in B-cell precursor ALL in a multicenter setting. |
264 | c 2020-12-14 | |
264 | 1 | b Springer Science and Business Media LLC,c 2021 |
520 | a PCR of TCR/Ig gene rearrangements is considered the method of choice for minimal residual disease (MRD) quantification in BCP-ALL, but flow cytometry analysis of leukemia-associated immunophenotypes (FCM-MRD) is faster and biologically more informative. FCM-MRD performed in 18 laboratories across seven countries was used for risk stratification of 1487 patients with BCP-ALL enrolled in the NOPHO ALL2008 protocol. When no informative FCM-marker was available, risk stratification was based on real-time quantitative PCR. An informative FCM-marker was found in 96.2% and only two patients (0.14%) had non-informative FCM and non-informative PCR-markers. The overall 5-year event-free survival was 86.1% with a cumulative incidence of relapse (CIR5y) of 9.5%. FCM-MRD levels on days 15 (HzR 4.0, p<0.0001), 29 (HzR 2.7, p<0.0001), and 79 (HzR 3.5, p<0.0001) associated with hazard of relapse adjusted for age, cytogenetics, and WBC. The early (day 15) response associated with CIR5y adjusted for day 29 FCM-MRD, with higher levels in adults (median 2.4×10-2 versus 5.2×10-3, p<0.0001). Undetectable FCM- and/or PCR-MRD on day 29 identified patients with a very good outcome (CIR5y=3.2%). For patients who did not undergo transplantation, day 79 FCM-MRD>10-4 associated with a CIR5y=22.1%. In conclusion, FCM-MRD performed in a multicenter setting is a clinically useful method for MRD-based treatment stratification in BCP-ALL. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Pediatrik0 (SwePub)302212 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Pediatrics0 (SwePub)302212 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
700 | 1 | a Hallböök, Heleneu Uppsala universitet,Uppsala University,Copenhagen University Hospital,Oslo university hospital,Hematologi,Copenhagen Univ Hosp, Rigshosp, Dept Clin Immunol, Copenhagen, Denmark.,Oslo Univ Hosp, Dept Pathol, Lab Mol Pathol, Oslo, Norway.4 aut0 (Swepub:uu)helehall |
700 | 1 | a Madsen, H Ou Umeå University,Umeå Univ, Dept Med Biosci, Pathol, Umeå, Sweden.4 aut |
700 | 1 | a Siitonen, Su University of Helsinki,University of Copenhagen,Univ Helsinki, Clin Chem, Helsinki, Finland.;Helsinki Univ Hosp, Helsinki, Finland.,Univ Copenhagen, Sect Biostat, Copenhagen, Denmark.4 aut |
700 | 1 | a Rosthøj, S4 aut |
700 | 1 | a Tierens, Au University of Toronto,Oslo university hospital,Univ Hlth Network, Lab Med Program, Toronto, ON, Canada.;Univ Toronto, Toronto, ON, Canada.;Univ Hosp Oslo, Dept Pathol, Oslo, Norway.4 aut |
700 | 1 | a Juvonen, Vu University of Turku,Univ Turku, Dept Clin Chem, Turku, Finland.;Univ Turku, Lab Div, Turku, Finland.;Turku Univ Hosp, Turku, Finland.4 aut |
700 | 1 | a Osnes, L T Nu Oslo university hospital,Herlev Hospital,Oslo Univ Hosp, Dept Immunol, Oslo, Norway.,Herlev Univ Hosp, Dept Hematol, Herlev, Denmark.4 aut |
700 | 1 | a Vålerhaugen, H4 aut |
700 | 1 | a Hultdin, Magnusu Umeå universitet,Patologi4 aut0 (Swepub:umu)magn0001 |
700 | 1 | a Matuzeviciene, Ru Vilnius University,Vilnius Univ, Inst Biomed Sci, Fac Med, Dept Physiol Biochem Microbiol & Lab Med, Vilnius, Lithuania.;Vilnius Univ Hosp, Santaros Klin, Ctr Lab Med, Vilnius, Lithuania.4 aut |
700 | 1 | a Stoskus, M4 aut |
700 | 1 | a Ehinger, M.u Lund University,Lunds universitet,Uppsala University,Patologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Pathology, Lund,Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital,Skane Univ Hosp, Dept Clin Genet & Pathol, Lund, Sweden.;Lund Univ, Dept Clin Sci Oncol & Pathol, Lund, Sweden.4 aut0 (Swepub:lu)efor-meh |
700 | 1 | a Lilleorg, Au North Estonia Medical Centre,North Estonia Med Ctr, Dept Clin Immunol, Tallinn, Estonia.4 aut |
700 | 1 | a Ehinger, M4 aut |
700 | 1 | a Norén-Nyström, Ulrikau Umeå University,Umeå universitet,Pediatrik,Umeå Univ, Dept Clin Sci, Pediat, Umeå, Sweden.4 aut0 (Swepub:umu)kagr0007 |
700 | 1 | a Toft, N4 aut |
700 | 1 | a Taskinen, Mu Helsinki University Central Hospital,Helsinki Univ Hosp, Div Pediat Hematol Oncol & Stem Cell Transplantat, Helsinki, Finland.4 aut |
700 | 1 | a Jónsson, O Gu National University Hospital of Iceland,Landspitali Univ Hosp, Childrens Hosp, Reykjavik, Iceland.4 aut |
700 | 1 | a Pruunsild, Ku Tallinn Children's Hospital,Tallinn Childrens Hosp, Tallinn, Estonia.4 aut |
700 | 1 | a Vaitkeviciene, Gu Vilnius University,Vilnius Univ Hosp, Santariskiu Klin, Childrens Hosp, Vilnius, Lithuania.4 aut |
700 | 1 | a Vettenranta, Ku University of Helsinki,Univ Helsinki, Helsinki, Finland.;Univ Helsinki, Childrens Hosp, Helsinki, Finland.4 aut |
700 | 1 | a Lund, Bu St. Olav’s University Hospital,St Olavs Univ Hosp, Dept Pediat, Trondheim, Norway.;NTNU, Dept Clin & Mol Med, Trondheim, Norway.4 aut |
700 | 1 | a Abrahamsson, Jonas,d 1954u Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Clinical Sciences, Department of Pediatrics,Sahlgrenska University Hospital,Sahlgrens Univ Hosp, Inst Clin Sci, Dept Pediat, Gothenburg, Sweden.4 aut0 (Swepub:gu)xabrjo |
700 | 1 | a Porwit, A.u Lund University,Lunds universitet,Patologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Pathology, Lund,Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund Univ, Fac Med, Dept Clin Sci, Div Oncol & Pathol, Lund, Sweden.4 aut0 (Swepub:lu)an6742po |
700 | 1 | a Schmiegelow, Ku Copenhagen University Hospital,Copenhagen Univ Hosp, Rigshosp, Dept Pediat & Adolescent Med, Copenhagen, Denmark.;Univ Copenhagen, Inst Clin Med, Fac Med, Copenhagen, Denmark.4 aut |
700 | 1 | a Marquart, H V4 aut |
700 | 1 | a Marincevic, Millaray,d 1983-u Uppsala universitet,Klinisk och experimentell patologi4 aut0 (Swepub:uu)milma629 |
710 | 2 | a Copenhagen University Hospitalb Vilnius University4 org |
773 | 0 | t Leukemiad : Springer Science and Business Media LLCg 35, s. 1894-1906q 35<1894-1906x 1476-5551x 0887-6924 |
856 | 4 | u https://www.nature.com/articles/s41375-020-01100-5.pdf |
856 | 4 | u https://doi.org/10.1038/s41375-020-01100-5y Fulltext |
856 | 4 | u https://umu.diva-portal.org/smash/get/diva2:1516830/FULLTEXT02.pdfx primaryx Raw objecty fulltext:print |
856 | 4 | u http://dx.doi.org/10.1038/s41375-020-01100-5x freey FULLTEXT |
856 | 4 | u https://uu.diva-portal.org/smash/get/diva2:1598564/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
856 | 4 8 | u https://gup.ub.gu.se/publication/299424 |
856 | 4 8 | u https://doi.org/10.1038/s41375-020-01100-5 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-178333 |
856 | 4 8 | u https://lup.lub.lu.se/record/7bab7e42-4df7-4f74-8d4f-140962a25921 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-454517 |
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