Sökning: onr:"swepub:oai:gup.ub.gu.se/300971" >
Association of diet...
Association of dietary and gut microbiota-related metabolites with calcific aortic stenosis
-
Duygu, K. (författare)
-
Tokgozoglu, L. (författare)
-
Gurses, K. M. (författare)
-
visa fler...
-
- Ståhlman, Marcus, 1975 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
-
- Borén, Jan, 1963 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
-
Soyal, M. F. T. (författare)
-
Canpinar, H. (författare)
-
Guc, D. (författare)
-
Ayhan, A. S. (författare)
-
Hazirolan, T. (författare)
-
Ozer, N. (författare)
-
visa färre...
-
(creator_code:org_t)
- 2020-12-18
- 2021
- Engelska.
-
Ingår i: Acta Cardiologica. - : Informa UK Limited. - 0001-5385 .- 0373-7934. ; 76:5, s. 544-522
- Relaterad länk:
-
https://gup.ub.gu.se...
-
visa fler...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- Background Histopathological changes in calcific aortic stenosis (CAS) resemble changes in coronary atherosclerosis. Concerning recent evidence on dietary and gut microbiota-related metabolites representing players in atherosclerosis, we aimed to investigate the link between dietary and gut microbiota-derived metabolites and CAS. Methods We consecutively recruited eligible subjects with moderate-severe CAS (n = 60), aortic sclerosis (ASc) (n = 49) and age and gender-matched control subjects (n = 48) in May 2016-December 2016. Plasma dietary and gut microbiota-related metabolite levels, namely choline, betaine, and trimethylamine N-oxide (TMAO), were measured using ultra-performance liquid chromatography-tandem mass spectroscopy method. Histopathological examinations were performed in patients that underwent aortic valve surgery. Results Prevalence of traditional cardiovascular risk factors or co-morbidities did not differ among groups (all p > 0.05). CAS patients had higher plasma choline levels compared to both control (p < 0.001) and ASc (p = 0.006). Plasma betaine and TMAO levels were similar (both p > 0.05). Compared to the lowest quartile choline levels (<11.15 mu M), patients with the highest quartile choline levels (>= 14.98 mu M) had higher aortic valvular (p < 0.001) and mitral annular (p = 0.013) calcification scores. Plasma choline levels were independently associated with aortic peak flow velocity (B +/- SE:0.165 +/- 0.060, p = 0.009). Choline levels were elevated in subjects who had aortic valves with denser lymphocyte infiltration (p < 0.001), neovascularization (p = 0.011), osseous metaplasia (p = 0.004), more severe tissue remodelling (p = 0.002) and calcification (p = 0.002). Conclusion We found a significant association between choline levels and CAS presence and severity depicted on imaging modalities and histopathological examinations. Our study may open new horizons for prevention of CAS.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- Calcific aortic stenosis
- choline
- betaine
- trimethylamine N-oxide
- trimethylamine-n-oxide
- acute coronary syndromes
- american society
- european association
- valve calcification
- prognostic value
- plasma
- choline
- betaine
- recommendations
- echocardiography
- Cardiovascular System & Cardiology
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Duygu, K.
-
Tokgozoglu, L.
-
Gurses, K. M.
-
Ståhlman, Marcus ...
-
Borén, Jan, 1963
-
Soyal, M. F. T.
-
visa fler...
-
Canpinar, H.
-
Guc, D.
-
Ayhan, A. S.
-
Hazirolan, T.
-
Ozer, N.
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Kardiologi
- Artiklar i publikationen
-
Acta Cardiologic ...
- Av lärosätet
-
Göteborgs universitet