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Sökning: onr:"swepub:oai:gup.ub.gu.se/301025" > Zona incerta neuron...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004827naa a2200601 4500
001oai:gup.ub.gu.se/301025
003SwePub
008240910s2021 | |||||||||||000 ||eng|
0247 a https://gup.ub.gu.se/publication/3010252 URI
0247 a https://doi.org/10.1113/jp2765132 DOI
040 a (SwePub)gu
041 a eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a de Git, K. C. G.4 aut
2451 0a Zona incerta neurons projecting to the ventral tegmental area promote action initiation towards feeding
264 c 2020-12-22
264 1b Wiley,c 2021
520 a Key points The zona incerta (ZI) and ventral tegmental area (VTA) are brain areas that are both implicated in feeding behaviour. The ZI projects to the VTA, although it has not yet been investigated whether this projection regulates feeding. We experimentally (in)activated the ZI to VTA projection by using dual viral vector technology, and studied the effects on feeding microstructure, the willingness to work for food, general activity and body temperature. Activity of the ZI to VTA projection promotes feeding by facilitating action initiation towards food, as reflected in meal frequency and the willingness to work for food reward, without affecting general activity or directly modulating body temperature. We show for the first time that activity of the ZI to VTA projection promotes feeding, which improves the understanding of the neurobiology of feeding behaviour and body weight regulation. Both the zona incerta (ZI) and the ventral tegmental area (VTA) have been implicated in feeding behaviour. The ZI provides prominent input to the VTA, although it has not yet been investigated whether this projection regulates feeding. Therefore, we investigated the role of ZI to VTA projection neurons in the regulation of several aspects of feeding behaviour. We determined the effects of (in)activation of ZI to VTA projection neurons on feeding microstructure, food-motivated behaviour under a progressive ratio schedule of reinforcement, locomotor activity and core body temperature. To activate or inactivate ZI neurons projecting to the VTA, we used a combination of canine adenovirus-2 in the VTA, as well as Cre-dependent designer receptors exclusively activated by designer drugs (DREADD) or tetanus toxin (TetTox) light chain in the ZI. TetTox-mediated inactivation of ZI to VTA projection neurons reduced food-motivated behaviour and feeding by reducing meal frequency. Conversely, DREADD-mediated chemogenetic activation of ZI to VTA projection neurons promoted food-motivated behaviour and feeding. (In)activation of ZI to VTA projection neurons did not affect locomotor activity or directly regulate core body temperature. Taken together, ZI neurons projecting to the VTA exert bidirectional control overfeeding behaviour. More specifically, activity of ZI to VTA projection neurons facilitate action initiation towards feeding, as reflected in both food-motivated behaviour and meal initiation, without affecting general activity.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng
653 a DREADD
653 a feeding
653 a motivation
653 a tetanus toxin light chain
653 a ventral
653 a tegmental area
653 a zona incerta
653 a dopamine neurons
653 a mesolimbic dopamine
653 a parkinsons-disease
653 a weight-gain
653 a food
653 a activation
653 a obesity
653 a reward
653 a motivation
653 a addiction
653 a Neurosciences & Neurology
653 a Physiology
7001 a Hazelhoff, E. M.4 aut
7001 a Nota, M. H. C.4 aut
7001 a Schele, Eriku Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology4 aut
7001 a Luijendijk, M. C. M.4 aut
7001 a Dickson, Suzanne L.,d 1966u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology4 aut0 (Swepub:gu)xdicsu
7001 a van der Plasse, G.4 aut
7001 a Adan, R. A. H.4 aut
7102 a Göteborgs universitetb Institutionen för neurovetenskap och fysiologi4 org
7730 t Journal of Physiology-Londond : Wileyg 559:2, s. 709-724q 559:2<709-724x 0022-3751x 1469-7793
8564 u https://physoc.onlinelibrary.wiley.com/doi/pdfdirect/10.1113/JP276513
8564 8u https://gup.ub.gu.se/publication/301025
8564 8u https://doi.org/10.1113/jp276513

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