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Randomized evaluati...
Randomized evaluation of beta blocker and ACE-inhibitor/angiotensin receptor blocker treatment in patients with myocardial infarction with non-obstructive coronary arteries (MINOCA-BAT): Rationale and design
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- Nordenskjöld, Anna, 1977- (författare)
- Örebro University,Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Cardiology
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- Agewall, S. (författare)
- Karolinska Institutet
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- Atar, D. (författare)
- Department of Cardiology, Oslo University Hospital, Norway, and Institute of Clinical Sciences, University of Oslo, Norway
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- Baron, Tomasz (författare)
- Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Kardiologi
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- Beltrame, J. (författare)
- Discipline of Medicine, University of Adelaide, Basil Hetzel Institute, Central Adelaide Local Health Network, Adelaide, Australia,Green Lane Cardiovascular Service, Auckland City Hospital, New Zealand
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- Bergstrom, O. (författare)
- Department of Medicine/Cardiology, County Hospital of Kronoberg, Sweden,Region Kronoberg
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- Erlinge, David (författare)
- Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Molekylär kardiologi,Forskargrupper vid Lunds universitet,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Molecular Cardiology,Lund University Research Groups
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- Gale, C. P. (författare)
- Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, UK
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- Lopez-Pais, J. (författare)
- Department of Cardiology, University Hospital Complex of Santiago de Compostela, Spain,Complejo Hospitalario Universitario de Santiago
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- Jernberg, T. (författare)
- Karolinska Institutet
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- Johansson, P. (författare)
- The Swedish Heart and Lung Association, Sweden,The Swedish Heart Lung Foundation
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- Ravn-Fischer, Annica, 1974 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine,Department of Cardiology, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Sweden
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- Reynolds, H. R. (författare)
- Sarah Ross Soter Center for Women's Cardiovascular Research, Leon H. Charney Division of Cardiology, Department of Medicine, NYU Grossman School of Medicine, New York, USA,New York University
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Somaratne, J. B. (författare)
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- Tornvall, P. (författare)
- Karolinska Institutet,Karolinska Institute
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- Lindahl, Bertil, 1957- (författare)
- Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Kardiologi
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(creator_code:org_t)
- Elsevier BV, 2021
- 2021
- Engelska.
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Ingår i: American Heart Journal. - : Elsevier BV. - 0002-8703 .- 1097-6744. ; 231, s. 96-104
- Relaterad länk:
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Abstract
Ämnesord
Stäng
- Background Myocardial infarction with non-obstructive coronary arteries (MINOCA) is common and occurs in 6-8% of all patients fulfilling the diagnostic criteria for acute myocardial infarction (AMI). This paper describes the rationale behind the trial 'Randomized Evaluation of Beta Blocker and ACE-Inhibitor/Angiotensin Receptor Blocker Treatment (ACEI/ARB) of MINOCA patients' (MINOCA-BAT) and the need to improve the secondary preventive treatment of MINOCA patients. Methods MINOCA-BAT is a registry-based, randomized, parallel, open-label, multicenter trial with 2:2 factorial design. The primary aim is to determine whether oral beta blockade compared with no oral beta blockade, and ACEI/ARB compared with no ACEI/ARB, reduce the composite endpoint of death of any cause, readmission because of AMI, ischemic stroke or heart failure in patients discharged after MINOCA without clinical signs of heart failure and with left ventricular ejection fraction >= 40%. A total of 3500 patients will be randomized into four groups; e.g. ACEI/ARB and beta blocker, beta blocker only, ACEI/ARB only and neither ACEI/ARB nor beta blocker, and followed for a mean of 4 years. Summary While patients with MINOCA have an increased risk of serious cardiovascular events and death, whether conventional secondary preventive therapies are beneficial has not been assessed in randomized trials. There is a limited basis for guideline recommendations in MINOCA. Furthermore, studies of routine clinical practice suggest that use of secondary prevention therapies in MINOCA varies considerably. Thus results from this trial may influence future treatment strategies and guidelines specific to MINOCA patients.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- secondary prevention
- magnetic-resonance
- mechanisms
- diagnosis
- disease
- Cardiovascular System & Cardiology
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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- Av författaren/redakt...
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Nordenskjöld, An ...
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Agewall, S.
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Atar, D.
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Baron, Tomasz
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Beltrame, J.
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Bergstrom, O.
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visa fler...
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Erlinge, David
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Gale, C. P.
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Lopez-Pais, J.
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Jernberg, T.
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Johansson, P.
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Ravn-Fischer, An ...
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Reynolds, H. R.
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Somaratne, J. B.
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Tornvall, P.
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Lindahl, Bertil, ...
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Göteborgs universitet
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Örebro universitet
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Lunds universitet
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Karolinska Institutet
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Uppsala universitet