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Significant salivar...
Significant salivary changes in relation to oral mucositis following autologous hematopoietic stem cell transplantation
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van Leeuwen, S. J. M. (författare)
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Proctor, G. B. (författare)
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Laheij, Amga (författare)
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visa fler...
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Potting, C. M. J. (författare)
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Smits, O. (författare)
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Bronkhorst, E. M. (författare)
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Hazenberg, M. D. (författare)
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Haverman, T. M. (författare)
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Brennan, M. T. (författare)
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- von Bültzingslöwen, Inger, 1947 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för odontologi, sektion 3,Institute of Odontology, Section 3
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Raber-Durlacher, J. E. (författare)
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Huysmans, Mcdnjm (författare)
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Rozema, F. R. (författare)
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Blijlevens, N. M. A. (författare)
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(creator_code:org_t)
- 2021-01-08
- 2021
- Engelska.
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Ingår i: Bone Marrow Transplantation. - : Springer Science and Business Media LLC. - 0268-3369 .- 1476-5365.
- Relaterad länk:
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https://www.nature.c...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- The aim of this multicentre, longitudinal study was to determine salivary changes in relation to oral mucositis (OM) in multiple myeloma patients following high-dose melphalan and autologous hematopoietic stem cell transplantation (ASCT). Unstimulated and stimulated whole-mouth saliva samples (UWS and SWS) were collected before ASCT, 1x/wk during the hospitalisation phase, and 3 and 12 months post-ASCT. During the hospitalisation period OM was scored 3x/wk (WHO system). Flow rate, pH, total protein concentration (Nanodrop), albumin, lactoferrin, neutrophil defensin-1 (HNP1), total IgA and S100A8/A9 (ELISA) were determined. Mixed models were used to evaluate differences between ulcerative (u)OM (>= 2 WHO, n = 20) and non-uOM (n = 31) groups. Until 18 days after ASCT, flow rate, pH, total IgA and HNP1 levels decreased in UWS and/or SWS, while log lactoferrin levels were significantly increased (UWS: p = 0.016 95% CI [0.36, 3.58], SWS: p < 0.001 95% CI [1.14, 3.29]). Twelve months post-ASCT, salivary protein levels were similar to baseline except for log total IgA, which was higher (UWS: p < 0.001 95% CI [0.49, 1.29], SWS: p < 0.001 95% CI [0.72, 1.45]). No differences between uOM and non-uOM groups were observed. Changes in salivary proteins indicated an inflammatory reaction in salivary glands coinciding with mucosal and systemic reactions in response to high-dose melphalan.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Odontologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Dentistry (hsv//eng)
Nyckelord
- high-dose melphalan
- myeloma patients
- lactoferrin
- mucosal
- complications
- calprotectin
- chemotherapy
- expression
- proteins
- therapy
- Biophysics
- Oncology
- Hematology
- Immunology
- Transplantation
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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van Leeuwen, S. ...
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Proctor, G. B.
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Laheij, Amga
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Potting, C. M. J ...
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Smits, O.
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Bronkhorst, E. M ...
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visa fler...
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Hazenberg, M. D.
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Haverman, T. M.
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Brennan, M. T.
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von Bültzingslöw ...
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Raber-Durlacher, ...
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Huysmans, Mcdnjm
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Rozema, F. R.
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Blijlevens, N. M ...
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Odontologi
- Artiklar i publikationen
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Bone Marrow Tran ...
- Av lärosätet
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Göteborgs universitet