Sökning: onr:"swepub:oai:gup.ub.gu.se/302280" > Violacein-Induced C...
Fältnamn | Indikatorer | Metadata |
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000 | 05018naa a2200709 4500 | |
001 | oai:gup.ub.gu.se/302280 | |
003 | SwePub | |
008 | 240528s2021 | |||||||||||000 ||eng| | |
024 | 7 | a https://gup.ub.gu.se/publication/3022802 URI |
024 | 7 | a https://doi.org/10.1021/acsinfecdis.0c004542 DOI |
040 | a (SwePub)gu | |
041 | a eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Tavella, Tatyana Almeida4 aut |
245 | 1 0 | a Violacein-Induced Chaperone System Collapse Underlies Multistage Antiplasmodial Activity. |
264 | c 2021-03-10 | |
264 | 1 | b American Chemical Society (ACS),c 2021 |
520 | a Antimalarial drugs with novel modes of action and wide therapeutic potential are needed to pave the way for malaria eradication. Violacein is a natural compound known for its biological activity against cancer cells and several pathogens, including the malaria parasite, Plasmodium falciparum (Pf). Herein, using chemical genomic profiling (CGP), we found that violacein affects protein homeostasis. Mechanistically, violacein binds Pf chaperones, PfHsp90 and PfHsp70-1, compromising the latter's ATPase and chaperone activities. Additionally, violacein-treated parasites exhibited increased protein unfolding and proteasomal degradation. The uncoupling of the parasite stress response reflects the multistage growth inhibitory effect promoted by violacein. Despite evidence of proteotoxic stress, violacein did not inhibit global protein synthesis via UPR activation-a process that is highly dependent on chaperones, in agreement with the notion of a violacein-induced proteostasis collapse. Our data highlight the importance of a functioning chaperone-proteasome system for parasite development and differentiation. Thus, a violacein-like small molecule might provide a good scaffold for development of a novel probe for examining the molecular chaperone network and/or antiplasmodial drug design. | |
650 | 7 | a NATURVETENSKAPx Biologix Biokemi och molekylärbiologi0 (SwePub)106022 hsv//swe |
650 | 7 | a NATURAL SCIENCESx Biological Sciencesx Biochemistry and Molecular Biology0 (SwePub)106022 hsv//eng |
650 | 7 | a NATURVETENSKAPx Biologix Cellbiologi0 (SwePub)106042 hsv//swe |
650 | 7 | a NATURAL SCIENCESx Biological Sciencesx Cell Biology0 (SwePub)106042 hsv//eng |
650 | 7 | a NATURVETENSKAPx Biologix Bioinformatik och systembiologi0 (SwePub)106102 hsv//swe |
650 | 7 | a NATURAL SCIENCESx Biological Sciencesx Bioinformatics and Systems Biology0 (SwePub)106102 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Farmaceutiska vetenskaper0 (SwePub)301012 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Pharmaceutical Sciences0 (SwePub)301012 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Mikrobiologi inom det medicinska området0 (SwePub)301092 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Microbiology in the medical area0 (SwePub)301092 hsv//eng |
650 | 7 | a NATURVETENSKAPx Data- och informationsvetenskapx Bioinformatik0 (SwePub)102032 hsv//swe |
650 | 7 | a NATURAL SCIENCESx Computer and Information Sciencesx Bioinformatics0 (SwePub)102032 hsv//eng |
700 | 1 | a da Silva, Noeli Soares Melo4 aut |
700 | 1 | a Spillman, Natalie4 aut |
700 | 1 | a Kayano, Ana Carolina Andrade Vitor4 aut |
700 | 1 | a Cassiano, Gustavo Capatti4 aut |
700 | 1 | a Vasconcelos, Adrielle Ayumi4 aut |
700 | 1 | a Camargo, Antônio Pedro4 aut |
700 | 1 | a da Silva, Djane Clarys Baia4 aut |
700 | 1 | a Fontinha, Diana4 aut |
700 | 1 | a Salazar Alvarez, Luis Carlos4 aut |
700 | 1 | a Ferreira, Letícia Tiburcio4 aut |
700 | 1 | a Peralis Tomaz, Kaira Cristina4 aut |
700 | 1 | a Neves, Bruno Junior4 aut |
700 | 1 | a Almeida, Ludimila Dias4 aut |
700 | 1 | a Bargieri, Daniel Youssef4 aut |
700 | 1 | a Lacerda, Marcus Vinicius Guimarães de4 aut |
700 | 1 | a Lemos Cravo, Pedro Vitor4 aut |
700 | 1 | a Sunnerhagen, Per,d 1959u Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology4 aut0 (Swepub:gu)xsuper |
700 | 1 | a Prudêncio, Miguel4 aut |
700 | 1 | a Andrade, Carolina Horta4 aut |
700 | 1 | a Pinto Lopes, Stefanie Costa4 aut |
700 | 1 | a Carazzolle, Marcelo Falsarella4 aut |
700 | 1 | a Tilley, Leann4 aut |
700 | 1 | a Bilsland, Elizabeth4 aut |
700 | 1 | a Borges, Júlio César4 aut |
700 | 1 | a Maranhão Costa, Fabio Trindade4 aut |
710 | 2 | a Göteborgs universitetb Institutionen för kemi och molekylärbiologi4 org |
773 | 0 | t ACS Infectious Diseasesd : American Chemical Society (ACS)g 7:4, s. 759-776q 7:4<759-776x 2373-8227 |
856 | 4 | u https://pubs.acs.org/doi/pdf/10.1021/acsinfecdis.0c00454 |
856 | 4 8 | u https://gup.ub.gu.se/publication/302280 |
856 | 4 8 | u https://doi.org/10.1021/acsinfecdis.0c00454 |
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