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  • Ingala, Silvia (author)

Application of the ATN classification scheme in a population without dementia: Findings from the EPAD cohort.

  • Article/chapterEnglish2021

Publisher, publication year, extent ...

  • 2021-04-03
  • Wiley,2021

Numbers

  • LIBRIS-ID:oai:gup.ub.gu.se/303594
  • https://gup.ub.gu.se/publication/303594URI
  • https://doi.org/10.1002/alz.12292DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:146368508URI

Supplementary language notes

  • Language:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • We classified non-demented European Prevention of Alzheimer's Dementia (EPAD) participants through the amyloid/tau/neurodegeneration (ATN) scheme and assessed their neuropsychological and imaging profiles.From 1500 EPAD participants, 312 were excluded. Cerebrospinal fluid cut-offs of 1000 pg/mL for amyloid beta (Aß)1-42 and 27 pg/mL for p-tau181 were validated using Gaussian mixture models. Given strong correlation of p-tau and t-tau (R2 =0.98, P<0.001), neurodegeneration was defined by age-adjusted hippocampal volume. Multinomial regressions were used to test whether neuropsychological tests and regional brain volumes could distinguish ATN stages.Age was 65 ± 7 years, with 58% females and 38% apolipoprotein E (APOE) ε4 carriers; 57.1% were A-T-N-, 32.5% were in the Alzheimer's disease (AD) continuum, and 10.4% suspected non-Alzheimer's pathology. Age and cerebrovascular burden progressed with biomarker positivity (P<0.001). Cognitive dysfunction appeared with T+. Paradoxically higher regional gray matter volumes were observed in A+T-N- compared to A-T-N- (P<0.001).In non-demented individuals along the AD continuum, p-tau drives cognitive dysfunction. Memory and language domains are affected in the earliest stages.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • De Boer, Casper (author)
  • Masselink, Larissa A (author)
  • Vergari, Ilaria (author)
  • Lorenzini, Luigi (author)
  • Blennow, Kaj,1958Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xbleka (author)
  • Chételat, Gaël (author)
  • Di Perri, Carol (author)
  • Ewers, Michael (author)
  • van der Flier, Wiesje M (author)
  • Fox, Nick C (author)
  • Gispert, Juan Domingo (author)
  • Haller, Sven (author)
  • Molinuevo, José Luís (author)
  • Muniz-Terrera, Graciela (author)
  • Mutsaerts, Henri Jmm (author)
  • Ritchie, Craig W (author)
  • Ritchie, Karen (author)
  • Schmidt, Mark (author)
  • Schwarz, Adam J (author)
  • Vermunt, Lisa (author)
  • Waldman, Adam D (author)
  • Wardlaw, Joanna (author)
  • Wink, Alle Meije (author)
  • Wolz, Robin (author)
  • Wottschel, Viktor (author)
  • Scheltens, Philip (author)
  • Visser, Pieter JelleKarolinska Institutet (author)
  • Barkhof, Frederik (author)
  • Göteborgs universitetInstitutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi (creator_code:org_t)

Related titles

  • In:Alzheimer's & dementia : the journal of the Alzheimer's Association: Wiley17:7, s. 1189-12041552-5279
  • In:Alzheimer's & Dementia: Wiley17:7, s. 1189-12041552-5260

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