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Sökning: onr:"swepub:oai:gup.ub.gu.se/303836" > Molecular Character...

  • Hua, Y.Southern Med Univ, Peoples R China; Karolinska Inst, Sweden (författare)

Molecular Characterization of the Enterohemolysin Gene (ehxA) in Clinical Shiga Toxin-Producing Escherichia coli Isolates

  • Artikel/kapitelEngelska2021

Förlag, utgivningsår, omfång ...

  • 2021-01-19
  • MDPI AG,2021

Nummerbeteckningar

  • LIBRIS-ID:oai:gup.ub.gu.se/303836
  • https://gup.ub.gu.se/publication/303836URI
  • https://doi.org/10.3390/toxins13010071DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:145726987URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-173422URI

Kompletterande språkuppgifter

  • Språk:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Funding Agencies|Scandinavian Society for Antimicrobial Chemotherapy Foundation [SLS884041]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81701977]; Natural Science Foundation of Guangdong ProvinceNational Natural Science Foundation of Guangdong Province [2018B030311063]; Guangdong Basic and Applied Basic Research Foundation [2019A1515111004]
  • Shiga toxin (Stx)-producing Escherichia coli (STEC) is an important foodborne pathogen with the ability to cause bloody diarrhea (BD) and hemolytic uremic syndrome (HUS). Little is known about enterohemolysin-encoded by ehxA. Here we investigated the prevalence and diversity of ehxA in 239 STEC isolates from human clinical samples. In total, 199 out of 239 isolates (83.26%) were ehxA positive, and ehxA was significantly overrepresented in isolates carrying stx(2a) + stx(2c) (p < 0.001) and eae (p < 0.001). The presence of ehxA was significantly associated with BD and serotype O157:H7. Five ehxA subtypes were identified, among which, ehxA subtypes B, C, and F were overrepresented in eae-positive isolates. All O157:H7 isolates carried ehxA subtype B, which was related to BD and HUS. Three ehxA groups were observed in the phylogenetic analysis, namely, group ? (ehxA subtype A), group II (ehxA subtype B, C, and F), and group (ehxA subtype D). Most BD- and HUS-associated isolates were clustered into ehxA group II, while ehxA group ? was associated with non-bloody stool and individuals >= 10 years of age. The presence of ehxA + eae and ehxA + eae + stx(2) was significantly associated with HUS and O157:H7 isolates. In summary, this study showed a high prevalence and the considerable genetic diversity of ehxA among clinical STEC isolates. The ehxA genotypes (subtype B and phylogenetic group II) could be used as risk predictors, as they were associated with severe clinical symptoms, such as BD and HUS. Furthermore, ehxA, together with stx and eae, can be used as a risk predictor for HUS in STEC infections.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Zhang, J.Massey Univ, New Zealand (författare)
  • Jernberg, C.Publ Hlth Agcy Sweden, Sweden (författare)
  • Chromek, M.Karolinska Institutet,Karolinska Inst, Sweden; Karolinska Univ Hosp, Sweden (författare)
  • Hansson, Sverker,1946Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Clinical Sciences, Department of Pediatrics,Sahlgrens Univ Hosp, Sweden; Univ Gothenburg, Sweden(Swepub:gu)xhansv (författare)
  • Frykman, Anne,1983Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Clinical Sciences, Department of Pediatrics,Sahlgrens Univ Hosp, Sweden; Univ Gothenburg, Sweden(Swepub:gu)xfryai (författare)
  • Xiong, Y. W.Chinese Ctr Dis Control & Prevent, Peoples R China (författare)
  • Wan, C. S.Southern Med Univ, Peoples R China (författare)
  • Matussek, AndreasLinköpings universitet,Karolinska Institutet,Avdelningen för inflammation och infektion,Medicinska fakulteten,Karolinska Inst, Sweden; Oslo Univ Hosp, Norway; Univ Oslo, Norway(Swepub:liu)andma17 (författare)
  • Bai, X. N.Karolinska Institutet,Chinese Ctr Dis Control & Prevent, Peoples R China; Karolinska Inst, Sweden (författare)
  • Southern Med Univ, Peoples R China; Karolinska Inst, SwedenMassey Univ, New Zealand (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Toxins: MDPI AG13:12072-6651

Internetlänk

Hitta via bibliotek

  • Toxins (Sök värdpublikationen i LIBRIS)

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