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Sarcopenia Definiti...
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Harvey, N. C.Univ Southampton, MRC Lifecourse Epidemiol Unit, Southampton SO16 6YD, Hants, England.;Univ Southampton, NIHR Southampton Biomed Res Ctr, Southampton, Hants, England.;Univ Hosp Southampton NHS Fdn Trust, Southampton, Hants, England.;Univ Oxford, NIHR Oxford Biomed Res Ctr, Oxford, England.
(författare)
Sarcopenia Definitions as Predictors of Fracture Risk Independent of FRAX(R), Falls, and BMD in the Osteoporotic Fractures in Men (MrOS) Study: A Meta-Analysis
- Artikel/kapitelEngelska2021
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LIBRIS-ID:oai:gup.ub.gu.se/304343
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https://gup.ub.gu.se/publication/304343URI
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https://doi.org/10.1002/jbmr.4293DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-454574URI
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Dual-energy X-ray absorptiometry (DXA)-derived appendicular lean mass/height(2) (ALM/ht(2)) is the most commonly used estimate of muscle mass in the assessment of sarcopenia, but its predictive value for fracture is substantially attenuated by femoral neck (fn) bone mineral density (BMD). We investigated predictive value of 11 sarcopenia definitions for incident fracture, independent of fnBMD, fracture risk assessment tool (FRAX(R)) probability, and prior falls, using an extension of Poisson regression in US, Sweden, and Hong Kong Osteoporois Fractures in Men Study (MrOS) cohorts. Definitions tested were those of Baumgartner and Delmonico (ALM/ht(2) only), Morley, the International Working Group on Sarcopenia, European Working Group on Sarcopenia in Older People (EWGSOP1 and 2), Asian Working Group on Sarcopenia, Foundation for the National Institutes of Health (FNIH) 1 and 2 (using ALM/body mass index [BMI], incorporating muscle strength and/or physical performance measures plus ALM/ht(2)), and Sarcopenia Definitions and Outcomes Consortium (gait speed and grip strength). Associations were adjusted for age and time since baseline and reported as hazard ratio (HR) for first incident fracture, here major osteoporotic fracture (MOF; clinical vertebral, hip, distal forearm, proximal humerus). Further analyses adjusted additionally for FRAX-MOF probability (n = 7531; calculated +/- fnBMD), prior falls (y/n), or fnBMD T-score. Results were synthesized by meta-analysis. In 5660 men in USA, 2764 Sweden and 1987 Hong Kong (mean ages 73.5, 75.4, and 72.4 years, respectively), sarcopenia prevalence ranged from 0.5% to 35%. Sarcopenia status, by all definitions except those of FNIH, was associated with incident MOF (HR = 1.39 to 2.07). Associations were robust to adjustment for prior falls or FRAX probability (without fnBMD); adjustment for fnBMD T-score attenuated associations. EWGSOP2 severe sarcopenia (incorporating chair stand time, gait speed, and grip strength plus ALM) was most predictive, albeit at low prevalence, and appeared only modestly influenced by inclusion of fnBMD. In conclusion, the predictive value for fracture of sarcopenia definitions based on ALM is reduced by adjustment for fnBMD but strengthened by additional inclusion of physical performance measures. (c) 2021 The Authors. Journal of Bone and Mineral Research published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research (ASBMR)..
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Orwoll, E.Oregon Hlth & Sci Univ, Portland, OR 97201 USA.
(författare)
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Kwok, T.Chinese Univ Hong Kong, Dept Med & Therapeut, Shatin, Hong Kong, Peoples R China.;Chinese Univ Hong Kong, Sch Publ Hlth, Shatin, Hong Kong, Peoples R China.
(författare)
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Karlsson, M. K.Lund Univ, Dept Clin Sci Malmö, Clin & Mol Osteoporosis Res Unit, Malmö, Sweden.;Skane Univ Hosp, Dept Orthoped, Malmö, Sweden.
(författare)
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Rosengren, B. E.Lund Univ, Dept Clin Sci Malmö, Clin & Mol Osteoporosis Res Unit, Malmö, Sweden.;Skane Univ Hosp, Dept Orthoped, Malmö, Sweden.
(författare)
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Ribom, Eva LUppsala universitet,Ortopedi(Swepub:uu)evlri676
(författare)
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Cauley, J. A.Univ Pittsburgh, Grad Sch Publ Hlth, Dept Epidemiol, Pittsburgh, PA 15260 USA.
(författare)
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Cawthon, P. M.Calif Pacific Med Ctr, Res Inst, San Francisco, CA USA.;Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA USA.
(författare)
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Ensrud, K.Univ Minnesota, Med & Epidemiol & Community Hlth, Minneapolis, MN USA.
(författare)
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Liu, E. W.Australian Catholic Univ, Mary MacKillop Inst Hlth Res, Melbourne, Vic, Australia.
(författare)
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Cruz-Jentoft, A. J.Hosp Univ Ramon & Cajal IRYCIS, Serv Geriatria, Madrid, Spain.
(författare)
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Fielding, R. A.Tufts Univ, Jean Mayer USDA Human Nutr Res Ctr Aging, Nutr Exercise Physiol & Sarcopenia Lab, Boston, MA 02111 USA.
(författare)
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Cooper, C.
(författare)
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Kanis, J. A.Australian Catholic Univ, Mary MacKillop Inst Hlth Res, Melbourne, Vic, Australia.;Univ Sheffield, Ctr Metab Bone Dis, Sheffield, S Yorkshire, England.
(författare)
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Lorentzon, Mattias,1970Gothenburg University,Göteborgs universitet,Institutionen för medicin,Centre for Bone and Arthritis Research,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition,Australian Catholic Univ, Mary MacKillop Inst Hlth Res, Melbourne, Vic, Australia.;Sahlgrens Univ Hosp, Sahlgrenska Acad, Inst Med, Geriatr Med, Mölndal, Sweden.(Swepub:gu)xlomat
(författare)
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Ohlsson, Claes,1965Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition,Univ Gothenburg, Inst Med, Ctr Bone & Arthrit Res, Dept Internal Med & Clin Nutr,Sahlgrenska Acad, Gothenburg, Sweden.;Sahlgrens Univ Hosp, Dept Drug Treatment, Reg Vastra Gotaland, Gothenburg, Sweden.(Swepub:gu)xohlcl
(författare)
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Mellström, Dan,1945Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Centre for Bone and Arthritis Research,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition,Univ Gothenburg, Inst Med, Ctr Bone & Arthrit Res, Dept Internal Med & Clin Nutr,Sahlgrenska Acad, Gothenburg, Sweden.(Swepub:gu)xmelda
(författare)
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Johansson, H.Australian Catholic Univ, Mary MacKillop Inst Hlth Res, Melbourne, Vic, Australia.;Univ Sheffield, Ctr Metab Bone Dis, Sheffield, S Yorkshire, England.
(författare)
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McCloskey, E.Univ Sheffield, Ctr Metab Bone Dis, Sheffield, S Yorkshire, England.;Univ Sheffield, Mellanby Ctr Bone Res, Ctr Integrated Res Musculoskeletal Ageing CIMA, Sheffield, S Yorkshire, England.
(författare)
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Univ Southampton, MRC Lifecourse Epidemiol Unit, Southampton SO16 6YD, Hants, England.;Univ Southampton, NIHR Southampton Biomed Res Ctr, Southampton, Hants, England.;Univ Hosp Southampton NHS Fdn Trust, Southampton, Hants, England.;Univ Oxford, NIHR Oxford Biomed Res Ctr, Oxford, England.Oregon Hlth & Sci Univ, Portland, OR 97201 USA.
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Journal of Bone and Mineral Research: Wiley36:7, s. 1235-12440884-04311523-4681
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- Av författaren/redakt...
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Harvey, N. C.
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Orwoll, E.
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Kwok, T.
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Karlsson, M. K.
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Rosengren, B. E.
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Ribom, Eva L
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visa fler...
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Cauley, J. A.
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Cawthon, P. M.
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Ensrud, K.
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Liu, E. W.
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Cruz-Jentoft, A. ...
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Fielding, R. A.
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Cooper, C.
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Kanis, J. A.
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Lorentzon, Matti ...
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Ohlsson, Claes, ...
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Mellström, Dan, ...
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Johansson, H.
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McCloskey, E.
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