Sökning: onr:"swepub:oai:gup.ub.gu.se/306426" > The strategic bioma...
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001 | oai:gup.ub.gu.se/306426 | |
003 | SwePub | |
008 | 240528s2021 | |||||||||||000 ||eng| | |
009 | oai:lup.lub.lu.se:98224d39-1a6f-4015-921d-f5be6e2d9b8d | |
009 | oai:prod.swepub.kib.ki.se:146254335 | |
024 | 7 | a https://gup.ub.gu.se/publication/3064262 URI |
024 | 7 | a https://doi.org/10.1007/s00259-020-05120-22 DOI |
024 | 7 | a https://lup.lub.lu.se/record/98224d39-1a6f-4015-921d-f5be6e2d9b8d2 URI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1462543352 URI |
040 | a (SwePub)gud (SwePub)lud (SwePub)ki | |
041 | a eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Boccardi, M.u German Center for Neurodegenerative Diseases (DZNE), Greifswald,University of Geneva4 aut |
245 | 1 0 | a The strategic biomarker roadmap for the validation of Alzheimer's diagnostic biomarkers: methodological update |
264 | c 2021-03-10 | |
264 | 1 | b Springer Science and Business Media LLC,c 2021 |
520 | a Background The 2017 Alzheimer's disease (AD) Strategic Biomarker Roadmap (SBR) structured the validation of AD diagnostic biomarkers into 5 phases, systematically assessing analytical validity (Phases 1-2), clinical validity (Phases 3-4), and clinical utility (Phase 5) through primary and secondary Aims. This framework allows to map knowledge gaps and research priorities, accelerating the route towards clinical implementation. Within an initiative aimed to assess the development of biomarkers of tau pathology, we revised this methodology consistently with progress in AD research. Methods We critically appraised the adequacy of the 2017 Biomarker Roadmap within current diagnostic frameworks, discussed updates at a workshop convening the Alzheimer's Association and 8 leading AD biomarker research groups, and detailed the methods to allow consistent assessment of aims achievement for tau and other AD diagnostic biomarkers. Results The 2020 update applies to all AD diagnostic biomarkers. In Phases 2-3, we admitted a greater variety of study designs (e.g., cross-sectional in addition to longitudinal) and reference standards (e.g., biomarker confirmation in addition to clinical progression) based on construct (in addition to criterion) validity. We structured a systematic data extraction to enable transparent and formal evidence assessment procedures. Finally, we have clarified issues that need to be addressed to generate data eligible to evidence-to-decision procedures. Discussion This revision allows for more versatile and precise assessment of existing evidence, keeps up with theoretical developments, and helps clinical researchers in producing evidence suitable for evidence-to-decision procedures. Compliance with this methodology is essential to implement AD biomarkers efficiently in clinical research and diagnostics. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicin0 (SwePub)3022 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicine0 (SwePub)3022 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Neurologi0 (SwePub)302072 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Neurology0 (SwePub)302072 hsv//eng |
653 | a Biomarker | |
653 | a Alzheimer’ | |
653 | a s disease | |
653 | a Dementia | |
653 | a MCI | |
653 | a Mild cognitive | |
653 | a impairment | |
653 | a Validation methodology | |
653 | a Radiology | |
653 | a Nuclear Medicine & Medical Imaging | |
653 | a Alzheimer’s disease | |
653 | a Mild cognitive impairment | |
700 | 1 | a Dodich, A.u University of Trento,University of Geneva4 aut |
700 | 1 | a Albanese, E.u Università della Svizzera Italiana4 aut |
700 | 1 | a Gayet-Ageron, A.u University of Geneva,Geneva University Hospital4 aut |
700 | 1 | a Festari, C.u Centro San Giovanni di Dio Fatebenefratelli4 aut |
700 | 1 | a Ashton, Nicholas J.u University of Gothenburg,Gothenburg University,Göteborgs universitet,Wallenberg Centre for Molecular and Translational Medicine,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,South London and Maudsley NHS Foundation Trust,King's College London4 aut0 (Swepub:gu)xashtn |
700 | 1 | a Bischof, G. N.u University Hospital of Cologne4 aut |
700 | 1 | a Chiotis, K.u Karolinska Institutet,Karolinska Institute,Karolinska University Hospital4 aut |
700 | 1 | a Leuzy, Antoineu Karolinska Institute4 aut0 (Swepub:lu)an3415le |
700 | 1 | a Wolters, E. E.u Amsterdam UMC - Vrije Universiteit Amsterdam,Vrije Universiteit Amsterdam4 aut |
700 | 1 | a Walter, M. A.u Geneva University Hospital4 aut |
700 | 1 | a Rabinovici, G. D.u University of California, San Francisco4 aut |
700 | 1 | a Carrillo, M.u Alzheimer's Association: Alzheimer's Disease and Dementia4 aut |
700 | 1 | a Drzezga, A.u University of Cologne,German Center for Neurodegenerative Diseases (DZNE), Bonn,Jülich Research Centre4 aut |
700 | 1 | a Hansson, Oskaru Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)mphy-ohn |
700 | 1 | a Nordberg, A.u Karolinska Institutet,Karolinska Institute,Karolinska University Hospital4 aut |
700 | 1 | a Ossenkoppele, Riku Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Vrije Universiteit Amsterdam,Amsterdam UMC - Vrije Universiteit Amsterdam4 aut0 (Swepub:lu)ri1513os |
700 | 1 | a Villemagne, V. L.u Austin Health,University of Pittsburgh4 aut |
700 | 1 | a Winblad, B.u Karolinska Institute,Karolinska University Hospital4 aut |
700 | 1 | a Frisoni, G. B.u University of Geneva,Geneva University Hospital4 aut |
700 | 1 | a Garibotto, V.u University of Geneva,Geneva University Hospital4 aut |
710 | 2 | a German Center for Neurodegenerative Diseases (DZNE), Greifswaldb University of Geneva4 org |
773 | 0 | t European Journal of Nuclear Medicine and Molecular Imagingd : Springer Science and Business Media LLCg 48, s. 2070-2085q 48<2070-2085x 1619-7070x 1619-7089 |
856 | 4 | u https://link.springer.com/content/pdf/10.1007/s00259-020-05120-2.pdf |
856 | 4 | u http://dx.doi.org/10.1007/s00259-020-05120-2x freey FULLTEXT |
856 | 4 8 | u https://gup.ub.gu.se/publication/306426 |
856 | 4 8 | u https://doi.org/10.1007/s00259-020-05120-2 |
856 | 4 8 | u https://lup.lub.lu.se/record/98224d39-1a6f-4015-921d-f5be6e2d9b8d |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:146254335 |
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