Sökning: onr:"swepub:oai:gup.ub.gu.se/306566" > Lateral Preoptic Ar...
Fältnamn | Indikatorer | Metadata |
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000 | 03896naa a2200433 4500 | |
001 | oai:gup.ub.gu.se/306566 | |
003 | SwePub | |
008 | 240910s2021 | |||||||||||000 ||eng| | |
024 | 7 | a https://gup.ub.gu.se/publication/3065662 URI |
024 | 7 | a https://doi.org/10.3389/fphys.2021.6827112 DOI |
040 | a (SwePub)gu | |
041 | a eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Lamy, Gustavo B4 aut |
245 | 1 0 | a Lateral Preoptic Area Neurons Activated by Angiotensin-(1-7) Increase Intravesical Pressure: A Novel Feature in Central Micturition Control. |
264 | c 2021-07-12 | |
264 | 1 | b Frontiers Media SA,c 2021 |
520 | a Central micturition control and urine storage involve a multisynaptic neuronal circuit for the efferent control of the urinary bladder. Electrical stimulation of the lateral preoptic area (LPA) at the level of the decussation of the anterior commissure in cats evokes relaxation of the bladder, whereas ventral stimulation of LPA evokes vigorous contraction. Endogenous Angiotensin-(1-7) [(Ang-(1-7)] synthesis depends on ACE-2, and its actions on binding to Mas receptors, which were found in LPA neurons. We aimed to investigate the Ang-(1-7) actions into the LPA on intravesical pressure (IP) and cardiovascular parameters. The gene and protein expressions of Mas receptors and ACE-2 were also evaluated in the LPA. Angiotensin-(1-7) (5 nmol/μL) or A-779 (Mas receptor antagonist, 50 nmol/μL) was injected into the LPA in anesthetized female Wistar rats; and the IP, mean arterial pressure (MAP), heart rate (HR), and renal conductance (RC) were recorded for 30 min. Unilateral injection of Ang-(1-7) into the LPA increased IP (187.46 ± 37.23%) with peak response at ∼23-25-min post-injection and yielded no changes in MAP, HR, and RC. Unilateral or bilateral injections of A-779 into the LPA decreased IP (-15.88 ± 2.76 and -27.30 ± 3.40%, respectively) and elicited no changes in MAP, HR, and RC. The genes and the protein expression of Mas receptors and ACE-2 were found in the LPA. Therefore, the LPA is an important part of the circuit involved in the urinary bladder control, in which the Ang-(1-7) synthetized into the LPA activates Mas receptors for increasing the IP independent on changes in RC and cardiovascular parameters. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Fysiologi0 (SwePub)301062 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Physiology0 (SwePub)301062 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Farmakologi och toxikologi0 (SwePub)301022 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Pharmacology and Toxicology0 (SwePub)301022 hsv//eng |
653 | a ACE-2; intravesical pressure; lateral preoptic area; mas receptor; micturition; urinary bladder | |
700 | 1 | a Cafarchio, Eduardo M4 aut |
700 | 1 | a do Vale, Bárbara4 aut |
700 | 1 | a Antonio, Bruno B4 aut |
700 | 1 | a Venancio, Daniel P4 aut |
700 | 1 | a de Souza, Janaina S4 aut |
700 | 1 | a Maciel, Rui M4 aut |
700 | 1 | a Giannocco, Gisele4 aut |
700 | 1 | a Aronsson, Patrik,d 1983u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för farmakologi,Institute of Neuroscience and Physiology, Department of Pharmacology4 aut0 (Swepub:gu)xaropa |
700 | 1 | a Sato, Monica A4 aut |
710 | 2 | a Göteborgs universitetb Institutionen för neurovetenskap och fysiologi, sektionen för farmakologi4 org |
773 | 0 | t Frontiers in physiologyd : Frontiers Media SAg 12q 12x 1664-042X |
856 | 4 | u https://www.frontiersin.org/articles/10.3389/fphys.2021.682711/pdf |
856 | 4 8 | u https://gup.ub.gu.se/publication/306566 |
856 | 4 8 | u https://doi.org/10.3389/fphys.2021.682711 |
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