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Biomarkers and cell...
Biomarkers and cell-based models to predict the outcome of neoadjuvant therapy for rectal cancer patients
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- Alkan, Aylin (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för kirurgi,Institute of Clinical Sciences, Department of Surgery
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- Hofving, Tobias, 1989 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för kirurgi,Institute of Clinical Sciences, Department of Surgery
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- Angenete, Eva, 1972 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för kirurgi,Institute of Clinical Sciences, Department of Surgery
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- Yrlid, Ulf, 1971 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi,Institute of Biomedicine, Department of Microbiology and Immunology
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(creator_code:org_t)
- 2021-07-28
- 2021
- Engelska.
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Ingår i: Biomarker Research. - : Springer Science and Business Media LLC. - 2050-7771. ; 9
- Relaterad länk:
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https://biomarkerres...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Rectal cancer constitutes approximately one-third of all colorectal cancers and contributes to considerable mortality globally. In contrast to colon cancer, the standard treatment for localized rectal cancer often involves neoadjuvant chemoradiotherapy. Tumour response rates to treatment show substantial inter-patient heterogeneity, indicating a need for treatment stratification. Consequently researchers have attempted to establish new means for predicting tumour response in order to assist in treatment decisions. In this review we have summarized published findings regarding potential biomarkers to predict neoadjuvant treatment response for rectal cancer tumours. In addition, we describe cell-based models that can be utilized both for treatment prediction and for studying the complex mechanisms involved.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- Rectal cancer
- Biomarkers
- Neoadjuvant therapy
- Microenvironment
- Patient-derived xenografts
- Patient-derived organoids
- tumor-infiltrating lymphocytes
- growth-factor receptor
- lymph-node
- ratio
- death-ligand 1
- gene-expression
- colorectal-cancer
- preoperative
- chemoradiotherapy
- chemoradiation therapy
- microsatellite instability
- complete response
- Oncology
- Research & Experimental Medicine
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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