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Univariate and biva...
Univariate and bivariate variance component linkage analysis of a whole-genome scan for loci contributing to bone mineral density
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Devoto, Marcella (författare)
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Spotila, Loretta D. (författare)
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Stabley, Deborah L. (författare)
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Wharton, Gina N. (författare)
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- Rydbeck, Halfdan, 1972 (författare)
- Gothenburg University,Göteborgs universitet,Core Facilities
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Korkko, Jarmo (författare)
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Kosich, Richard (författare)
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Prockop, Darwin (författare)
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Tenenhouse, Alan (författare)
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Sol-Church, Katia (författare)
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(creator_code:org_t)
- 2005-04-13
- 2005
- Engelska.
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Ingår i: European Journal of Human Genetics. - : Springer Science and Business Media LLC. - 1018-4813 .- 1476-5438. ; 13, s. 781-788
- Relaterad länk:
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https://www.nature.c...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Osteoporosis is a common condition characterized by reduced skeletal strength and increased susceptibility to fracture. The single major risk factor for osteoporosis is low bone mineral density (BMD) and strong evidence exists that genetic factors are in part responsible for an individual's BMD. A cohort of 40 multiplex Caucasian families selected through a proband with osteoporosis was genotyped for microsatellite markers spaced at an average of 10 cM, and linkage to femoral neck (FN), lumbar spine (LS) and trochanter (TR) BMD was analyzed using univariate and bivariate variance component linkage analysis. Maximum univariate multipoint lod-scores were 2.87 on chromosome 1p36 for FN BMD, 1.89 on 6q27 for TR BMD, and 2.15 on 7p15 for LS BMD. Results of bivariate linkage analysis were highly correlated with those of the univariate analysis, although generally less significant, suggesting the possibility that some of these susceptibility loci may exert pleiotropic effects on multiple skeletal sites.
Ämnesord
- NATURVETENSKAP -- Data- och informationsvetenskap -- Bioinformatik (hsv//swe)
- NATURAL SCIENCES -- Computer and Information Sciences -- Bioinformatics (hsv//eng)
Nyckelord
- Bone mineral density
- Genome scan
- Linkage analysis
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Devoto, Marcella
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Spotila, Loretta ...
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Stabley, Deborah ...
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Wharton, Gina N.
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Rydbeck, Halfdan ...
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Korkko, Jarmo
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visa fler...
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Kosich, Richard
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Prockop, Darwin
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Tenenhouse, Alan
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Sol-Church, Kati ...
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visa färre...
- Om ämnet
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- NATURVETENSKAP
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NATURVETENSKAP
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och Data och informa ...
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och Bioinformatik
- Artiklar i publikationen
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European Journal ...
- Av lärosätet
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Göteborgs universitet