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Dehydro-Tocotrienol...
Dehydro-Tocotrienol-beta Counteracts Oxidative-Stress-Induced Diabetes Complications in db/db Mice
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Dallner, G. (författare)
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Bentinger, M. (författare)
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- Hussain, Shafaat (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
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- Sinha, I. (författare)
- Karolinska Institutet
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Yang, J. N. (författare)
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Schwank-Xu, C. (författare)
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- Zheng, X. W. (författare)
- Karolinska Institutet
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Swiezewska, E. (författare)
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- Brismar, K. (författare)
- Karolinska Institutet
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Valladolid-Acebes, I. (författare)
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Tekle, M. (författare)
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(creator_code:org_t)
- 2021-07-02
- 2021
- Engelska.
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Ingår i: Antioxidants. - : MDPI AG. - 2076-3921. ; 10:7
- Relaterad länk:
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https://www.mdpi.com...
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https://gup.ub.gu.se...
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https://doi.org/10.3...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Hyperglycemia, hyperlipidemia, and adiposity are the main factors that cause inflammation in type 2 diabetes due to excessive ROS production, leading to late complications. To counteract the effects of increased free radical production, we searched for a compound with effective antioxidant properties that can induce coenzyme Q biosynthesis without affecting normal cellular functions. Tocotrienols are members of the vitamin E family, well-known as efficient antioxidants that are more effective than tocopherols. Deh-T3 beta is a modified form of the naturally occurring tocotrienol-beta. The synthesis of this compound involves the sequential modification of geranylgeraniol. In this study, we investigated the effects of this compound in different experimental models of diabetes complications. Deh-T3 beta was found to possess multifaceted capacities. In addition to enhanced wound healing, deh-T3 beta improved kidney and liver functions, reduced liver steatosis, and improved heart recovery after ischemia and insulin sensitivity in adipose tissue in a mice model of type 2 diabetes. Deh-T3 beta exerts these positive effects in several organs of the diabetic mice without reducing the non-fasting blood glucose levels, suggesting that both its antioxidant properties and improvement in mitochondrial function are involved, which are central to reducing diabetes complications.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Nyckelord
- coenzyme Q
- antioxidants
- tocotrienol
- diabetes
- oxidative stress
- diabetes complications
- wound healing
- vitamin-e
- coenzyme q(10)
- dysfunction
- biosynthesis
- antioxidant
- metabolism
- cells
- Biochemistry & Molecular Biology
- Pharmacology & Pharmacy
- Food Science
- & Technology
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Dallner, G.
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Bentinger, M.
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Hussain, Shafaat
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Sinha, I.
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Yang, J. N.
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Schwank-Xu, C.
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visa fler...
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Zheng, X. W.
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Swiezewska, E.
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Brismar, K.
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Valladolid-Acebe ...
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Tekle, M.
-
visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Endokrinologi oc ...
- Artiklar i publikationen
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Antioxidants
- Av lärosätet
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Göteborgs universitet
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Karolinska Institutet