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Case report: acrome...
Case report: acromegaly and breast cancer in a woman with turner syndrome
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- Naessen, S. (författare)
- Karolinska Institutet
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- Landin-Wilhelmsen, Kerstin, 1952 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition
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(creator_code:org_t)
- 2021-08-06
- 2021
- Engelska.
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Ingår i: Gynecological Endocrinology. - : Informa UK Limited. - 0951-3590 .- 1473-0766. ; 37:11, s. 1046-1049
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https://gup.ub.gu.se...
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Abstract
Ämnesord
Stäng
- Purpose To present a case with a woman with Turner syndrome (TS) with acromegaly and breast cancer, in her medical history. Method A descriptive case report of a single patient. Results The woman had short stature and lack of puberty and was not treated with hormones. When she was 36-year-old, acromegaly was diagnosed. She was treated with transsphenoidal surgery, followed by external radiation on the adenoma, without any affection on the pituitary gland. Annual controls revealed ordinary pituitary axes during 40 years' follow-up. She was treated for hypertension, had an aortic dilatation and started menopausal hormone therapy (MHT),1 mg estradiol and 0.5 mg norethisterone acetate daily, at the age of 50, due to osteoporosis. At the age of 60, she was diagnosed with breast cancer at the mammography screening. After, mastectomy, neoadjuvant radiation, and treatment with tamoxifen citrate were given due to the tubular breast cancer. Conclusions Despite a possible growth hormone (GH) resistance and lack of endogenous estradiol in women with TS, this patient was diagnosed with acromegaly and breast cancer. This case demonstrates the potential for co-occurring two hormonally active tumors in a woman with TS with monosomy karyotype.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Nyckelord
- Turner syndrome
- acromegaly
- breast cancer
- tubular carcinoma
- hormone replacement therapy
- prospective cohort
- sex-hormones
- women
- risk
- height
- complications
- pathogenesis
- metaanalysis
- mortality
- Endocrinology & Metabolism
- Obstetrics & Gynecology
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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