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Perivascular spaces...
Perivascular spaces are associated with tau pathophysiology and synaptic dysfunction in early Alzheimer's continuum
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Vilor-Tejedor, N. (författare)
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Ciampa, I. (författare)
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Operto, G. (författare)
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visa fler...
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Falcon, C. (författare)
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Suarez-Calvet, M. (författare)
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Crous-Bou, M. (författare)
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Shekari, M. (författare)
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Arenaza-Urquijo, E. M. (författare)
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Mila-Aloma, M. (författare)
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Grau-Rivera, O. (författare)
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Minguillon, C. (författare)
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Kollmorgen, G. (författare)
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- Zetterberg, Henrik, 1973 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Blennow, Kaj, 1958 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Guigo, R. (författare)
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Molinuevo, J. L. (författare)
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Gispert, J. D. (författare)
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visa färre...
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(creator_code:org_t)
- 2021-08-05
- 2021
- Engelska.
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Ingår i: Alzheimer's Research & Therapy. - : Springer Science and Business Media LLC. - 1758-9193. ; 13:1
- Relaterad länk:
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https://alzres.biome...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background Perivascular spaces (PVS) have an important role in the elimination of metabolic waste from the brain. It has been hypothesized that the enlargement of PVS (ePVS) could be affected by pathophysiological mechanisms involved in Alzheimer's disease (AD), such as abnormal levels of CSF biomarkers. However, the relationship between ePVS and these pathophysiological mechanisms remains unknown. Objective We aimed to investigate the association between ePVS and CSF biomarkers of several pathophysiological mechanisms for AD. We hypothesized that ePVS will be associated to CSF biomarkers early in the AD continuum (i.e., amyloid positive cognitively unimpaired individuals). Besides, we explored associations between ePVS and demographic and cardiovascular risk factors. Methods The study included 322 middle-aged cognitively unimpaired participants from the ALFA + study, many within the Alzheimer's continuum. NeuroToolKit and Elecsys (R) immunoassays were used to measure CSF A beta 42, A beta 40, p-tau and t-tau, NfL, neurogranin, TREM2, YKL40, GFAP, IL6, S100, and alpha-synuclein. PVS in the basal ganglia (BG) and centrum semiovale (CS) were assessed based on a validated 4-point visual rating scale. Odds ratios were calculated for associations of cardiovascular and AD risk factors with ePVS using logistic and multinomial models adjusted for relevant confounders. Models were stratified by A beta status (positivity defined as A beta 42/40 < 0.071). Results The degree of PVS significantly increased with age in both, BG and CS regions independently of cardiovascular risk factors. Higher levels of p-tau, t-tau, and neurogranin were significantly associated with ePVS in the CS of A beta positive individuals, after accounting for relevant confounders. No associations were detected in the BG neither in A beta negative participants. Conclusions Our results support that ePVS in the CS are specifically associated with tau pathophysiology, neurodegeneration, and synaptic dysfunction in asymptomatic stages of the Alzheimer's continuum.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Nyckelord
- Alzheimer's disease
- MRI
- CSF biomarkers
- Perivascular spaces
- Tau
- pathophysiology
- Virchow-Robin spaces
- virchow-robin spaces
- small vessel disease
- dementia
- severity
- risk
- age
- Neurosciences & Neurology
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Vilor-Tejedor, N ...
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Ciampa, I.
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Operto, G.
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Falcon, C.
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Suarez-Calvet, M ...
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Crous-Bou, M.
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visa fler...
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Shekari, M.
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Arenaza-Urquijo, ...
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Mila-Aloma, M.
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Grau-Rivera, O.
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Minguillon, C.
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Kollmorgen, G.
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Zetterberg, Henr ...
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Blennow, Kaj, 19 ...
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Guigo, R.
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Molinuevo, J. L.
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Gispert, J. D.
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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och Neurovetenskaper
- Artiklar i publikationen
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Alzheimer's Rese ...
- Av lärosätet
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Göteborgs universitet