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Neuroblastoma xenog...
Neuroblastoma xenograft models demonstrate the therapeutic potential of Lu-177-octreotate
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- Romiani, Arman, 1991 (författare)
- Gothenburg University,Göteborgs universitet,Sahlgrenska Centrum för Cancerforskning (SCCR),Institutionen för kliniska vetenskaper, Avdelningen för medicinsk strålningsvetenskap,Sahlgrenska Center for Cancer Research (SCCR),Institute of Clinical Sciences, Department of Medical Radiation Sciences
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- Spetz, Johan (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för medicinsk strålningsvetenskap,Sahlgrenska Centrum för Cancerforskning (SCCR),Institute of Clinical Sciences, Department of Medical Radiation Sciences,Sahlgrenska Center for Cancer Research (SCCR)
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- Shubbar, Emman, 1974 (författare)
- Gothenburg University,Göteborgs universitet,Sahlgrenska Centrum för Cancerforskning (SCCR),Institutionen för kliniska vetenskaper, Avdelningen för medicinsk strålningsvetenskap,Sahlgrenska Center for Cancer Research (SCCR),Institute of Clinical Sciences, Department of Medical Radiation Sciences
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- Lind, Dan E., 1988 (författare)
- Gothenburg University,Göteborgs universitet,Sahlgrenska Centrum för Cancerforskning (SCCR),Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi,Sahlgrenska Center for Cancer Research (SCCR),Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology
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- Hallberg, Bengt, 1956 (författare)
- Gothenburg University,Göteborgs universitet,Sahlgrenska Centrum för Cancerforskning (SCCR),Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi,Sahlgrenska Center for Cancer Research (SCCR),Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology
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- Palmer, Ruth H., 1970 (författare)
- Gothenburg University,Göteborgs universitet,Sahlgrenska Centrum för Cancerforskning (SCCR),Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi,Sahlgrenska Center for Cancer Research (SCCR),Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology
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- Forssell-Aronsson, Eva, 1961 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för medicinsk strålningsvetenskap,Sahlgrenska Centrum för Cancerforskning (SCCR),Institute of Clinical Sciences, Department of Medical Radiation Sciences,Sahlgrenska Center for Cancer Research (SCCR)
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(creator_code:org_t)
- 2021-08-25
- 2021
- Engelska.
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Ingår i: BMC Cancer. - : Springer Science and Business Media LLC. - 1471-2407. ; 21:1
- Relaterad länk:
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https://bmccancer.bi...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background Neuroblastoma (NB) is one of the most frequently diagnosed tumors in infants. NB is a neuroendocrine tumor type with various characteristics and features, and with diverse outcome. The most malignant NBs have a 5-year survival rate of only 40-50%, indicating the need for novel and improved treatment options. Lu-177-octreotate is routinely administered for treatment of neuroendocrine tumors overexpressing somatostatin receptors (SSTR). The aim of this study was to examine the biodistribution of Lu-177-octreotate in mice bearing aggressive human NB cell lines, in order to evaluate the potential usefulness of Lu-177-octreotate for treatment of NB. Methods BALB/c nude mice bearing CLB-BAR, CLB-GE or IMR-32 tumor xenografts (n = 5-7/group) were i.v. injected with 0.15 MBq, 1.5 MBq or 15 MBq Lu-177-octreotate and sacrificed 1 h, 24 h, 48 h and 168 h after administration. The radioactivity concentration was determined for collected tissue samples, tumor-to-normal-tissue activity concentration ratios (T/N) and mean absorbed dose for each tissue were calculated. Immunohistochemical (IHC) staining for SSTR1-5, and Ki67 were carried out for tumor xenografts from the three cell lines. Results High Lu-177 concentration levels and T/N values were observed in all NB tumors, with the highest for CLB-GE tumor xenografts (72%IA/g 24 h p.i.; 1.5 MBq Lu-177-octreotate). The mean absorbed dose to the tumor was 6.8 Gy, 54 Gy and 29 Gy for CLB-BAR, CLB-GE and IMR-32, respectively, p.i. of 15 MBq Lu-177-octreotate. Receptor saturation was clearly observed in CLB-BAR, resulting in higher concentration levels in the tumor when lower activity levels where administered. IHC staining demonstrated highest expression of SSTR2 in CLB-GE, followed by CLB-BAR and IMR-32. Conclusion T/N values for all three human NB tumor xenograft types investigated were high relative to previously investigated neuroendocrine tumor types. The results indicate a clear potential of Lu-177-octreotate as a therapeutic alternative for metastatic NB.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- Neuroendocrine tumor
- Peptide receptor radionuclide therapy
- Somatostatin receptors
- Lu-177-DOTATATE
- Lutathera
- high-risk neuroblastoma
- nude-mice
- dose-escalation
- somatostatin
- biodistribution
- expression
- tumor
- rearrangements
- dosimetry
- alk
- Oncology
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Romiani, Arman, ...
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Spetz, Johan
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Shubbar, Emman, ...
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Lind, Dan E., 19 ...
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Hallberg, Bengt, ...
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Palmer, Ruth H., ...
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Forssell-Aronsso ...
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Cancer och onkol ...
- Artiklar i publikationen
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BMC Cancer
- Av lärosätet
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Göteborgs universitet