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Efficacy of a novel...
Efficacy of a novel device for cryoprevention of oral mucositis: a randomized, blinded, multicenter, parallel group, phase 3 trial
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- Walladbegi, Java (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för odontologi,Institute of Odontology,Department of Oral Medicine and Pathology, Institute of Odontology, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
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- Henriksson, Roger (författare)
- Umeå universitet,Onkologi
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- Tavelin, Björn (författare)
- Umeå universitet,Onkologi
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- Svanberg, Anncarin, 1956- (författare)
- Uppsala universitet,Hematologi
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- Larfors, Gunnar (författare)
- Uppsala universitet,Hematologi
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- Jadersten, M. (författare)
- Karolinska Institutet
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- Schjesvold, F. (författare)
- Oslo Myeloma Centre, Department of Hematology, Oslo University Hospital, Oslo, Norway; K.G. Jebsen Centre for B-cell Malignancies, University of Oslo, Oslo, Norway
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- Mahdi, A. (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för odontologi,Institute of Odontology,Department of Oral Medicine and Pathology, Institute of Odontology, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
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- Legert, K. G. (författare)
- Karolinska Institutet
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- Peterson, D. E. (författare)
- Department of Oral Health and Diagnostic Sciences, School of Dental Medicine, UConn Health, CT, Farmington, United States
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- Jontell, Mats, 1951 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för odontologi, sektion 1,Institute of Odontology, Section 1,Department of Oral Medicine and Pathology, Institute of Odontology, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
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(creator_code:org_t)
- 2021-11-03
- 2022
- Engelska.
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Ingår i: Bone Marrow Transplantation. - : Springer Science and Business Media LLC. - 0268-3369 .- 1476-5365. ; 57, s. 191-197
- Relaterad länk:
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https://www.nature.c...
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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https://uu.diva-port... (primary) (Raw object)
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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http://kipublication...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Cryoprevention (CP) using ice (IC) is an effective strategy to prevent chemotherapy-induced oral mucositis (OM). However, the use of IC may cause adverse reactions and requires water of safe quality to minimize risk of serious infections. This randomized, blinded, parallel group, phase 3 trial was conducted in five Scandinavian centers. Eligible patients were diagnosed with multiple myeloma or lymphoma, scheduled to receive conditioning with high-dose chemotherapy prior to autologous hematopoietic stem cell transplantation (ASCT). Patients were assigned to cooling with IC or a novel intraoral cooling device (ICD). The primary outcome was the highest OM score during the study period, expressed as peak value on the Oral Mucositis Assessment Scale (OMAS-total). When the entire study population (n = 172) was analyzed for peak OMAS-total, the two cooling methods were equally effective. However, when the lymphoma group was analyzed separately, the ICD significantly reduced the peak OMAS-total score to a greater extent compared to IC (x +/- SD; 1.77 +/- 1.59 vs. 3.08 +/- 1.50; p = 0.047). Combined with existing evidence, the results of the present trial confirm that CP is an effective method to prevent OM. ClinicalTrials.gov. NCT03203733.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Nyckelord
- pseudomonas-aeruginosa
- legionnaires-disease
- cryotherapy
- chemotherapy
- prevention
- palifermin
- therapy
- water
- Biophysics
- Oncology
- Hematology
- Immunology
- Transplantation
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Walladbegi, Java
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Henriksson, Roge ...
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Tavelin, Björn
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Svanberg, Anncar ...
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Larfors, Gunnar
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Jadersten, M.
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visa fler...
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Schjesvold, F.
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Mahdi, A.
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Legert, K. G.
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Peterson, D. E.
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Jontell, Mats, 1 ...
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Hematologi
- Artiklar i publikationen
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Bone Marrow Tran ...
- Av lärosätet
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Göteborgs universitet
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Umeå universitet
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Karolinska Institutet
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Uppsala universitet