Sökning: onr:"swepub:oai:gup.ub.gu.se/310869" > Serum and cerebrosp...
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000 | 05241naa a2200721 4500 | |
001 | oai:gup.ub.gu.se/310869 | |
003 | SwePub | |
008 | 240910s2021 | |||||||||||000 ||eng| | |
024 | 7 | a https://gup.ub.gu.se/publication/3108692 URI |
024 | 7 | a https://doi.org/10.1093/braincomms/fcab0992 DOI |
040 | a (SwePub)gu | |
041 | a eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Paterson, Ross W4 aut |
245 | 1 0 | a Serum and cerebrospinal fluid biomarker profiles in acute SARS-CoV-2-associated neurological syndromes. |
264 | c 2021-05-12 | |
264 | 1 | b Oxford University Press (OUP),c 2021 |
520 | a Preliminary pathological and biomarker data suggest that SARS-CoV-2 infection can damage the nervous system. To understand what, where and how damage occurs, we collected serum and CSF from patients with COVID-19 and characterized neurological syndromes involving the PNS and CNS (n=34). We measured biomarkers of neuronal damage and neuroinflammation, and compared these with non-neurological control groups, which included patients with (n=94) and without (n=24) COVID-19. We detected increased concentrations of neurofilament light, a dynamic biomarker of neuronal damage, in the CSF of those with CNS inflammation (encephalitis and acute disseminated encephalomyelitis) [14800pg/ml (400, 32400)], compared to those with encephalopathy [1410pg/ml (756, 1446)], peripheral syndromes (Guillain-Barré syndrome) [740pg/ml (507, 881)] and controls [872pg/ml (654, 1200)]. Serum neurofilament light levels were elevated across patients hospitalized with COVID-19, irrespective of neurological manifestations. There was not the usual close correlation between CSF and serum neurofilament light, suggesting serum neurofilament light elevation in the non-neurological patients may reflect peripheral nerve damage in response to severe illness. We did not find significantly elevated levels of serum neurofilament light in community cases of COVID-19 arguing against significant neurological damage. Glial fibrillary acidic protein, a marker of astrocytic activation, was not elevated in the CSF or serum of any group, suggesting astrocytic activation is not a major mediator of neuronal damage in COVID-19. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng |
653 | a ADEM | |
653 | a COVID-19 | |
653 | a NfL | |
700 | 1 | a Benjamin, Laura A4 aut |
700 | 1 | a Mehta, Puja R4 aut |
700 | 1 | a Brown, Rachel L4 aut |
700 | 1 | a Athauda, Dilan4 aut |
700 | 1 | a Ashton, Nicholas J.u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xashtn |
700 | 1 | a Leckey, Claire A4 aut |
700 | 1 | a Ziff, Oliver J4 aut |
700 | 1 | a Heaney, Judith4 aut |
700 | 1 | a Heslegrave, Amanda J4 aut |
700 | 1 | a Lessa Benedet, Andréau Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xlesan |
700 | 1 | a Blennow, Kaj,d 1958u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xbleka |
700 | 1 | a Checkley, Anna M4 aut |
700 | 1 | a Houlihan, Catherine F4 aut |
700 | 1 | a Mummery, Catherine J4 aut |
700 | 1 | a Lunn, Michael P4 aut |
700 | 1 | a Manji, Hadi4 aut |
700 | 1 | a Zandi, Michael S4 aut |
700 | 1 | a Keddie, Stephen4 aut |
700 | 1 | a Chou, Michael4 aut |
700 | 1 | a Vinayan Changaradil, Deepthi4 aut |
700 | 1 | a Solomon, Tom4 aut |
700 | 1 | a Keshavan, Ashvini4 aut |
700 | 1 | a Barker, Suzanne4 aut |
700 | 1 | a Jäger, Hans Rolf4 aut |
700 | 1 | a Carletti, Francesco4 aut |
700 | 1 | a Simister, Robert4 aut |
700 | 1 | a Werring, David J4 aut |
700 | 1 | a Spyer, Moira J4 aut |
700 | 1 | a Nastouli, Eleni4 aut |
700 | 1 | a Gauthier, Serge4 aut |
700 | 1 | a Rosa-Neto, Pedro4 aut |
700 | 1 | a Zetterberg, Henrik,d 1973u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xzethe |
700 | 1 | a Schott, Jonathan M4 aut |
710 | 2 | a Göteborgs universitetb Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi4 org |
773 | 0 | t Brain communicationsd : Oxford University Press (OUP)g 3:3q 3:3x 2632-1297 |
856 | 4 | u https://academic.oup.com/braincomms/article-pdf/3/3/fcab099/41728326/fcab099.pdf |
856 | 4 8 | u https://gup.ub.gu.se/publication/310869 |
856 | 4 8 | u https://doi.org/10.1093/braincomms/fcab099 |
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