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Long-term follow-up...
Long-term follow-up and sex differences in adults operated for tetralogy of Fallot
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Quattrone, Alessia (författare)
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Lie, Oyvind H. (författare)
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Nestaas, Eirik (författare)
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- de Lange, Charlotte, 1963 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för radiologi,Institute of Clinical Sciences, Department of Radiology
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Try, Kirsti (författare)
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Lindberg, Harald L. (författare)
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Skulstad, Helge (författare)
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Erikssen, Gunnar (författare)
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Edvardsen, Thor (författare)
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Haugaa, Kristina (författare)
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Estensen, Mette E. (författare)
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- 2021-10-18
- 2021
- Engelska.
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Ingår i: Open Heart. - : BMJ. - 2398-595X .- 2053-3624. ; 8:2
- Relaterad länk:
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https://openheart.bm...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Objective Adults operated for tetralogy of Fallot (TOF) have high risk of ventricular arrhythmias (VA). QRS duration >180 ms is an established risk factor for VA. We aimed to investigate heart function, prevalence of arrhythmias and sex differences in patients with TOF at long-term follow-up. Methods We included TOF-operated patients≥18 years from our centre's registry. We reviewed medical records and the most recent echocardiographic exam. VA was recorded on ECGs, 24-hour Holter registrations and from implantable cardioverter defibrillator. Results We included 148 patients (age 37±10 years). Left ventricular global longitudinal strain (LV GLS,-15.8±3.1% vs-18.8±3.2%, p=0.001) and right ventricular (RV) GLS (-15.8±3.9% vs-19.1±4.1%, p=0.001) were lower in men at all ages compared with women. Higher RV D1 (4.3±0.5 cm vs 4.6±0.6 cm, p=0.01), lower ejection fraction (55%±8% vs 50%±9%, p=0.02), lower RV GLS (-18.1±4.0 ms vs-16.1±4.8 ms, p=0.04) and N-terminal pro-brain natriuretic peptide (NT-proBNP) over reference range (n=27 (23%) vs n=8 (77%), p<0.001) were associated with higher incidence of VA. QRS duration was longer in men (151±30 ms vs 128±25 ms, p<0.001). No patients had QRS duration >180 ms. QRS duration did not differ in those with and without VA (143±32 ms vs 137±28 ms, p=0.06). Conclusions Our results confirmed reduced RV function in adults operated for TOF. Male patients had impaired LV and RV function expressed by lower LV and RV GLS values at all ages. Reduced cardiac function and elevated NT-proBNP were associated with higher incidence of VA and may be important in risk assessment.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Nyckelord
- arrhythmias
- cardiac
- echocardiography
- heart failure
- systolic
- tetralogy of Fallot
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Quattrone, Aless ...
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Lie, Oyvind H.
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Nestaas, Eirik
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de Lange, Charlo ...
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Try, Kirsti
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Lindberg, Harald ...
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visa fler...
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Skulstad, Helge
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Erikssen, Gunnar
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Edvardsen, Thor
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Haugaa, Kristina
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Estensen, Mette ...
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
- Artiklar i publikationen
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Open Heart
- Av lärosätet
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Göteborgs universitet