Sökning: onr:"swepub:oai:gup.ub.gu.se/314275" >
Analysis of normal ...
Analysis of normal levels of free glycosaminoglycans in urine and plasma in adults
-
- Bratulic, Sinisa, 1981 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology
-
- Limeta, Angelo, 1996 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology
-
- Maccari, F. (författare)
- Universita Degli Studi Di Modena E Reggio Emilia,University of Modena and Reggio Emilia
-
visa fler...
-
- Galeotti, F. (författare)
- Universita Degli Studi Di Modena E Reggio Emilia,University of Modena and Reggio Emilia
-
- Volpi, N. (författare)
- Universita Degli Studi Di Modena E Reggio Emilia,University of Modena and Reggio Emilia
-
- Levin, Max, 1969 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Wallenberglaboratoriet,Institute of Medicine, Department of Molecular and Clinical Medicine,Wallenberg Laboratory,Sahlgrenska universitetssjukhuset,Sahlgrenska University Hospital,University of Gothenburg
-
- Nielsen, Jens B, 1962 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology,BioInnovation Institute (BII)
-
- Gatto, Francesco, 1987 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology
-
visa färre...
-
(creator_code:org_t)
- Elsevier BV, 2022
- 2022
- Engelska.
-
Ingår i: Journal of Biological Chemistry. - : Elsevier BV. - 0021-9258 .- 1083-351X. ; 298:2
- Relaterad länk:
-
http://www.jbc.org/a...
-
visa fler...
-
https://research.cha... (primary) (free)
-
https://gup.ub.gu.se...
-
https://doi.org/10.1...
-
https://research.cha...
-
visa färre...
Abstract
Ämnesord
Stäng
- Plasma and urine glycosaminoglycans (GAGs) are long, linear sulfated polysaccharides that have been proposed as potential noninvasive biomarkers for several diseases. However, owing to the analytical complexity associated with the measurement of GAG concentration and disaccharide composition (the so-called GAGome), a reference study of the normal healthy GAGome is currently missing. Here, we prospectively enrolled 308 healthy adults and analyzed their free GAGomes in urine and plasma using a standardized ultra-high-performance liquid chromatography coupled with triple-quadrupole tandem mass spectrometry method together with comprehensive demographic and blood chemistry biomarker data. Of 25 blood chemistry biomarkers, we mainly observed weak correlations between the free GAGome and creatinine in urine and hemoglobin or erythrocyte counts in plasma. We found a higher free GAGome concentration - but not a more diverse composition - in males. Partitioned by gender, we also established reference intervals for all detectable free GAGome features in urine and plasma. Finally, we carried out a transference analysis in healthy individuals from two distinct geographical sites, including data from the Lifelines Cohort Study, which validated the reference intervals in urine. Our study is the first large-scale determination of normal free GAGomes reference intervals in plasma and urine and represents a critical resource for future physiology and biomarker research. © 2022 THE AUTHORS. Published by Elsevier Inc on behalf of American Society for Biochemistry and Molecular Biology. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Ämnesord
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
- NATURVETENSKAP -- Kemi -- Analytisk kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Analytical Chemistry (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Klinisk laboratoriemedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Clinical Laboratory Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
Nyckelord
- Blood
- High performance liquid chromatography
- Mass spectrometry
- Blood chemistry
- Glycosaminoglycans
- Haemoglobins
- Healthy individuals
- Long linear
- Measurements of
- Sulfated polysaccharides
- Triple quadrupole tandem mass spectrometry
- Ultra-high performance liquid chromatographies
- Weak correlation
- Biomarkers
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Bratulic, Sinisa ...
-
Limeta, Angelo, ...
-
Maccari, F.
-
Galeotti, F.
-
Volpi, N.
-
Levin, Max, 1969
-
visa fler...
-
Nielsen, Jens B, ...
-
Gatto, Francesco ...
-
visa färre...
- Om ämnet
-
- NATURVETENSKAP
-
NATURVETENSKAP
-
och Biologi
-
och Biokemi och mole ...
-
- NATURVETENSKAP
-
NATURVETENSKAP
-
och Kemi
-
och Analytisk kemi
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Klinisk laborato ...
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Hälsovetenskap
-
och Arbetsmedicin oc ...
- Artiklar i publikationen
-
Journal of Biolo ...
- Av lärosätet
-
Göteborgs universitet
-
Chalmers tekniska högskola