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Assessment of Dieta...
Assessment of Dietary Choline Intake, Contributing Food Items, and Associations with One-Carbon and Lipid Metabolites in Middle-Aged and Elderly Adults: The Hordaland Health Study
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Van Parys, A. (författare)
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Brække, M. S. (författare)
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- Karlsson, Therese, 1979 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition
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Vinknes, K. J. (författare)
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Tell, G. S. (författare)
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Haugsgjerd, T. R. (författare)
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Ueland, P. M. (författare)
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Øyen, J. (författare)
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Dierkes, J. (författare)
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Nygård, O. (författare)
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Lysne, V. (författare)
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(creator_code:org_t)
- Elsevier BV, 2022
- 2022
- Engelska.
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Ingår i: Journal of Nutrition. - : Elsevier BV. - 0022-3166. ; 152:2, s. 513-524
- Relaterad länk:
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https://academic.oup...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background: Choline is an essential nutrient for humans and is involved in various physiologic functions. Through its metabolite betaine, it is closely connected to the one-carbon metabolism, and the fat-soluble choline form phosphatidylcholine is essential for VLDL synthesis and secretion in the liver connecting choline to the lipid metabolism. Dietary recommendations for choline are not available in the Nordic countries primarily due to data scarcity. Objectives: The aim of this study was to investigate the dietary intake of total choline and individual choline forms, dietary sources, and the association of total choline intake with circulating one-carbon metabolites and lipids. Methods: We included 5746 participants in the Hordaland Health Study, a survey including community-dwelling adults born in 1925-1927 (mean age 72 y, 55% women) and 1950-1951 (mean age 48 y, 57% women). Dietary data were obtained using a 169-item FFQ, and choline content was calculated using the USDA Database for Choline Content of Common Foods, release 2. Metabolites of the one-carbon and lipid metabolism were measured in a nonfasting blood sample obtained at baseline, and the association with total choline intake was assessed using polynomial splines. Results: The geometric mean (95% prediction interval) energy-adjusted total choline intake was 260 (170, 389) mg/d, with phosphatidylcholine being the main form (44%). The major food items providing dietary choline were eggs, low-fat milk, potatoes, and leafy vegetables. Dietary total choline was inversely associated with circulating concentrations of total homocysteine, glycine, and serine and positively associated with choline, methionine, cystathionine, cysteine, trimethyllysine, trimethylamine-N-oxide, and dimethylglycine. A weak association was observed between choline intake and serum lipids. Conclusions: Phosphatidylcholine was the most consumed choline form in community-dwelling adults in Norway. Our findings suggest that choline intake is associated with the concentration of most metabolites involved in the one-carbon and lipid metabolism. © 2021 The Author(s). Published by Oxford University Press on behalf of the American Society for Nutrition.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Nyckelord
- choline
- dietary intake
- lipid metabolism
- one-carbon metabolism
- phosphatidylcholine
- carbon
- cholesterol
- cystathionine
- cysteine
- dimethylglycine
- glycerophosphorylcholine
- glycine
- high density lipoprotein cholesterol
- homocysteine
- lipid
- low density lipoprotein cholesterol
- lysine derivative
- methionine
- monounsaturated fatty acid
- phosphorylcholine
- polyunsaturated fatty acid
- serine
- short chain fatty acid
- sphingomyelin
- triacylglycerol
- trimethylamine oxide
- betaine
- adult
- aged
- Article
- caloric intake
- candy
- carbohydrate intake
- carbon metabolism
- cholesterol blood level
- community dwelling person
- controlled study
- dairy product
- egg
- fast food
- fat intake
- female
- fish consumption
- food frequency questionnaire
- fruit consumption
- grain
- groups by age
- human
- leafy vegetable
- low fat milk
- macronutrient intake
- major clinical study
- male
- meat consumption
- metabolite
- middle aged
- nutritional assessment
- potato
- protein intake
- vegetable consumption
- diet
- eating
- vegetable
- very elderly
- Aged
- 80 and over
- Humans
- Lipids
- Vegetables
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Van Parys, A.
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Brække, M. S.
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Karlsson, Theres ...
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Vinknes, K. J.
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Tell, G. S.
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Haugsgjerd, T. R ...
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visa fler...
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Ueland, P. M.
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Øyen, J.
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Dierkes, J.
-
Nygård, O.
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Lysne, V.
-
visa färre...
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- MEDICIN OCH HÄLSOVETENSKAP
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och Klinisk medicin
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Journal of Nutri ...
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Göteborgs universitet