Characterization of novel nonacid glycosphingolipids as biomarkers of human gastric adenocarcinoma

• degenerative changes appear leading to premalignant conditions as atrofic gastritis, metaplasia, and dysplasia. binding of bacterial adhesins to carbohydrate receptors on the gastric epithelium. A number of different carbohydrate receptor been reported (reviewed in Ref. (2)). Despite the multitude of candidate H. pylori glycan receptors, only three carbohydratebinding adhesins have been characterized to date; the blood group antigen-binding BabA adhesin, the sialic acid-binding SabA adhesin, and the LabA adhesin (reviewed in Ref. (3)). adhesin BabA (4). H. pylori strains expressing BabA together with VacA and CagA (triple-positive strains) are highly associated with severe gastric diseases, as peptic ulcer or gastric adenocarcinoma. BabA mediates the initial attachment of H. pylori to the human gastric mucosa. The first observation recognized by H. pylori BabA was followed by a division of BabA-producing H. pylori strains into specialist and generalist strains, depending on their mode of binding to Leb and related carbohydrate sequences (5). BabA of specialist strains binds

Ämnesord

NATURVETENSKAP  -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)

NATURAL SCIENCES  -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)

Nyckelord

blood-group antigens

helicobacter-pylori

mass-spectrometry

tn

antigen

binding gangliosides

cancer

expression

glycolipids

adhesin

glycoprotein

Biochemistry & Molecular Biology

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)