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Cytokine responses ...
Cytokine responses to LPS in reprogrammed monocytes are associated with the transcription factor PU.1
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- Tuerxun, Kaya, 1981- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Inflammatory Response and Infection Susceptibility Centre (iRiSC), Faculty of Medicine and Health Örebro University, Örebro, Sweden
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- Midtbö, Kristine, 1991- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Inflammatory Response and Infection Susceptibility Centre (iRiSC), Faculty of Medicine and Health Örebro University, Örebro, Sweden
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- Särndahl, Eva, 1963- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Inflammatory Response and Infection Susceptibility Centre (iRiSC), Faculty of Medicine and Health Örebro University, Örebro, Sweden
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- Vorontsov, Egor, 1988 (författare)
- Gothenburg University,Göteborgs universitet,Core Facilities, Proteomics,Core Facilities, Proteomics,Proteomics Core Facility, Sahlgrenska Academy University of Gothenburg, Gothenburg, Sweden
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- Karlsson, Roger, 1975 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine,Department of Infectious Diseases, Institute of Biomedicine, Sahlgrenska Academy of the University of Gothenburg Sweden; Department of Clinical Microbiology, Sahlgrenska University Hospital, Region Västra Götaland, Sweden; Nanoxis Consulting AB, Gothenburg, Sweden
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- Persson, Alexander, 1978- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Inflammatory Response and Infection Susceptibility Centre (iRiSC), Faculty of Medicine and Health Örebro University, Örebro, Sweden
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- Kruse, Robert, 1972- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Inflammatory Response and Infection Susceptibility Centre (iRiSC), Faculty of Medicine and Health Örebro University, Örebro, Sweden; Department of Clinical Research Laboratory, Faculty of Medicine and Health, Örebro University, Örebro, Sweden
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- Eklund, D. (författare)
- Faculty of Medicine and Health, School of Medical Sciences Örebro University Örebro Sweden;Inflammatory Response and Infection Susceptibility Centre (iRiSC), Faculty of Medicine and Health Örebro University Örebro Sweden
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(creator_code:org_t)
- 2022-03-13
- 2022
- Engelska.
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Ingår i: Journal of Leukocyte Biology. - : Oxford University Press (OUP). - 0741-5400 .- 1938-3673. ; 112:4, s. 679-692
- Relaterad länk:
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https://doi.org/10.1...
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https://oru.diva-por... (primary) (Raw object)
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Myeloid-derived suppressor cells (MDSCs) are functionally immunosuppressive cells that arise and expand during extensive inflammatory conditions by increased hematopoietic output or reprogramming of immune cells. In sepsis, an increase of circulating MDSCs is associated with adverse outcomes, but unique traits that can be used to identify increased activity of MDSCs are lacking. By using endotoxin tolerance as a model of sepsis-induced monocytic MDSCs (M-MDSC-like cells), this study aims to identify the mediator and transcriptional regulator profile associated with MMDSC activity. After analyzing 180 inflammation-associated proteins, a profile of differentially expressed cytokines was found in M-MDSC-like cells versus normal monocytes stimulated with LPS. These cytokines were associated with 5 candidate transcription factors, where particularly PU.1 showed differential expression on both transcriptional and protein levels in M-MDSC-like cells. Furthermore, inhibition of PU.1 led to increased production of CXCL5 and CCL8 in M-MDSC-like cells indicating its role in regulating the ability of M-M DSC-like cells to recruit other immune cells. Taken together, the study identifies a unique profile in the pattern of immune mediators defining M-MDSC activity upon LPS stimulation, which offers a functional link to their contribution to immunosuppression.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Nyckelord
- endotoxin tolerance
- immunosuppression
- inflammation
- MDSCs
- sepsis
- regulatory t-cells
- suppressor-cells
- endotoxin tolerance
- expression
- sepsis
- proliferation
- macrophages
- inhibition
- il-10
- cxcl5
- Cell Biology
- Hematology
- Immunology
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Tuerxun, Kaya, 1 ...
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Midtbö, Kristine ...
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Särndahl, Eva, 1 ...
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Vorontsov, Egor, ...
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Karlsson, Roger, ...
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Persson, Alexand ...
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Kruse, Robert, 1 ...
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Eklund, D.
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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och Immunologi inom ...
- Artiklar i publikationen
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Journal of Leuko ...
- Av lärosätet
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Göteborgs universitet
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Örebro universitet