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The Neuroimmune Res...
The Neuroimmune Response to Surgery - An Exploratory Study of Trauma-Induced Changes in Innate Immunity and Heart Rate Variability
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- Hildenborg, M. (författare)
- Karolinska Institutet
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- Kahlin, J. (författare)
- Karolinska Institutet
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- Granath, F. (författare)
- Karolinska Institutet
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visa fler...
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- Schening, A. (författare)
- Karolinska Institutet
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Granstrom, A. (författare)
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- Ebberyd, A. (författare)
- Karolinska Institutet
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Klevenvall, L. (författare)
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- Zetterberg, Henrik, 1973 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Han, J. M. (författare)
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- Schlegel, T. T. (författare)
- Karolinska Institutet
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- Harris, R. (författare)
- Karolinska Institutet
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- Harris, H. E. (författare)
- Karolinska Institutet
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- Eriksson, L. I. (författare)
- Karolinska Institutet
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(creator_code:org_t)
- 2022-07-07
- 2022
- Engelska.
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Ingår i: Frontiers in Immunology. - : Frontiers Media SA. - 1664-3224. ; 13
- Relaterad länk:
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https://gup.ub.gu.se...
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- Surgery triggers a systemic inflammatory response that ultimately impacts the brain and associates with long-term cognitive impairment. Adequate regulation of this immune surge is pivotal for a successful surgical recovery. We explored the temporal immune response in a surgical cohort and its associations with neuroimmune regulatory pathways and cognition, in keeping with the growing body of evidence pointing towards the brain as a regulator of peripheral inflammation. Brain-to-immune communication acts through cellular, humoral and neural pathways. In this context, the vagal nerve and the cholinergic anti-inflammatory pathway (CAP) have been shown to modify peripheral immune cell activity in both acute and chronic inflammatory conditions. However, the relevance of neuroimmune regulatory mechanisms following a surgical trauma is not yet elucidated. Twenty-five male patients undergoing elective laparoscopic abdominal surgery were included in this observational prospective study. Serial blood samples with extensive immune characterization, assessments of heart rate variability (HRV) and cognitive tests were performed before surgery and continuing up to 6 months post-surgery. Temporal immune responses revealed biphasic reaction patterns with most pronounced changes at 5 hours after skin incision and 14 days following surgery. Estimations of cardiac vagal nerve activity through HRV recordings revealed great individual variations depending on the pre-operative HRV baseline. A principal component analysis displayed distinct differences in systemic inflammatory biomarker trajectories primarily based on pre-operative HRV, with potiential consequences for long-term surgical outcomes. In conclusion, individual pre-operative HRV generates differential response patterns that associate with distinct inflammatory trajectories following surgery. Long-term surgical outcomes need to be examined further in larger studies with mixed gender cohorts.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Nyckelord
- surgery
- innate immunity
- heart rate variability (HRV)
- inflammation
- neuroimmune alterations
- perioperative neurocognitive disorders (PND)
- vagus nerve-stimulation
- qt interval variability
- esc working group
- inflammatory markers
- position statement
- activation
- disease
- cells
- Immunology
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Hildenborg, M.
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Kahlin, J.
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Granath, F.
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Schening, A.
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Granstrom, A.
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Ebberyd, A.
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visa fler...
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Klevenvall, L.
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Zetterberg, Henr ...
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Han, J. M.
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Schlegel, T. T.
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Harris, R.
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Harris, H. E.
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Eriksson, L. I.
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visa färre...
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- Artiklar i publikationen
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Frontiers in Imm ...
- Av lärosätet
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Göteborgs universitet
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Karolinska Institutet