Sökning: onr:"swepub:oai:gup.ub.gu.se/318756" > An online atlas of ...
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000 | 08752naa a2200793 4500 | |
001 | oai:gup.ub.gu.se/318756 | |
003 | SwePub | |
008 | 240528s2022 | |||||||||||000 ||eng| | |
009 | oai:DiVA.org:uu-486343 | |
009 | oai:DiVA.org:du-42775 | |
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024 | 7 | a https://gup.ub.gu.se/publication/3187562 URI |
024 | 7 | a https://doi.org/10.1038/s41467-022-33050-02 DOI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4863432 URI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:du-427752 URI |
024 | 7 | a https://lup.lub.lu.se/record/d8e42fb0-02a3-4b26-aec7-0753bc48d6772 URI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1507726802 URI |
040 | a (SwePub)gud (SwePub)uud (SwePub)dud (SwePub)lud (SwePub)ki | |
041 | a eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Dekkers, Koenu Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab,Uppsala University, Uppsala4 aut0 (Swepub:uu)koede543 |
245 | 1 0 | a An online atlas of human plasma metabolite signatures of gut microbiome composition. |
264 | c 2022-09-23 | |
264 | 1 | b Springer Science and Business Media LLC,c 2022 |
520 | a Human gut microbiota produce a variety of molecules, some of which enter the bloodstream and impact health. Conversely, dietary or pharmacological compounds may affect the microbiota before entering the circulation. Characterization of these interactions is an important step towards understanding the effects of the gut microbiota on health. In this cross-sectional study, we used deep metagenomic sequencing and ultra-high-performance liquid chromatography linked to mass spectrometry for a detailed characterization of the gut microbiota and plasma metabolome, respectively, of 8583 participants invited at age 50 to 64 from the population-based Swedish CArdioPulmonary bioImage Study. Here, we find that the gut microbiota explain up to 58% of the variance of individual plasma metabolites and we present 997 associations between alpha diversity and plasma metabolites and 546,819 associations between specific gut metagenomic species and plasma metabolites in an online atlas ( https://gutsyatlas.serve.scilifelab.se/ ). We exemplify the potential of this resource by presenting novel associations between dietary factors and oral medication with the gut microbiome, and microbial species strongly associated with the uremic toxin p-cresol sulfate. This resource can be used as the basis for targeted studies of perturbation of specific metabolites and for identification of candidate plasma biomarkers of gut microbiota composition. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Gastroenterologi0 (SwePub)302132 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Gastroenterology and Hepatology0 (SwePub)302132 hsv//eng |
650 | 7 | a NATURVETENSKAPx Biologix Mikrobiologi0 (SwePub)106062 hsv//swe |
650 | 7 | a NATURAL SCIENCESx Biological Sciencesx Microbiology0 (SwePub)106062 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi0 (SwePub)303022 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Public Health, Global Health, Social Medicine and Epidemiology0 (SwePub)303022 hsv//eng |
700 | 1 | a Sayols-Baixeras, Sergiu Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab,Inst Salud Carlos III, CIBER Cardiovasc Dis CIBERCV, Madrid, Spain.,Uppsala University, Uppsala; Instituto de Salud Carlos III, Madrid, Spain4 aut0 (Swepub:uu)sersa467 |
700 | 1 | a Baldanzi, Gabrielu Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab,Uppsala University, Uppsala4 aut0 (Swepub:uu)gabba126 |
700 | 1 | a Nowak, Christophu Karolinska Institute4 aut |
700 | 1 | a Hammar, Ulfu Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab,Uppsala University, Uppsala4 aut0 (Swepub:uu)ulfha881 |
700 | 1 | a Nguyen, Diem,c PhDu Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab,Uppsala University, Uppsala4 aut0 (Swepub:uu)dieng296 |
700 | 1 | a Varotsis, Georgiosu Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab,Uppsala University, Uppsala4 aut0 (Swepub:uu)geova785 |
700 | 1 | a Brunkwall, Louiseu Lund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups4 aut0 (Swepub:lu)med-lbw |
700 | 1 | a Nielsen, Nynneu Clin Microbi AS, Copenhagen, Denmark.,Clinical Microbiomics4 aut |
700 | 1 | a Eklund, Aron Cu Clin Microbi AS, Copenhagen, Denmark.,Clinical Microbiomics4 aut |
700 | 1 | a Bak Holm, Jacobu Clin Microbi AS, Copenhagen, Denmark.,Clinical Microbiomics4 aut |
700 | 1 | a Nielsen, H Bjørnu Clin Microbi AS, Copenhagen, Denmark.,Clinical Microbiomics4 aut |
700 | 1 | a Ottosson, Filipu Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups4 aut0 (Swepub:lu)immu-flo |
700 | 1 | a Yi-Ting, Lin,d 1981-u Uppsala University,Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:uu)yitli615 |
700 | 1 | a Ahmad, Shafqatu Uppsala University,Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:lu)med-sta |
700 | 1 | a Lind, Larsu Uppsala University,Uppsala universitet,Klinisk epidemiologi4 aut0 (Swepub:uu)larslind |
700 | 1 | a Sundström, Johan,c Professor,d 1971-u Uppsala University,Uppsala universitet,Klinisk epidemiologi,Univ New South Wales, George Inst Global Hlth, Sydney, NSW, Australia.,University of New South Wales4 aut0 (Swepub:uu)johasund |
700 | 1 | a Engström, Gunnaru Lund University,Lunds universitet,Kardiovaskulär forskning - epidemiologi,Forskargrupper vid Lunds universitet,Cardiovascular Research - Epidemiology,Lund University Research Groups4 aut0 (Swepub:lu)smi-gen |
700 | 1 | a Smith, J. Gustav,d 1982u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,Gothenburg Univ, Inst Med, Dept Mol & Clin Med, Wallenberg Lab, Gothenburg, Sweden.;Sahlgrens Univ Hosp, Dept Cardiol, Gothenburg, Sweden.;Lund Univ, Clin Sci, Dept Cardiol, Lund, Sweden.;Skane Univ Hosp, Lund, Sweden.;Lund Univ, Wallenberg Ctr Mol Med, Lund, Sweden.;Lund Univ, Diabet Ctr, Lund, Sweden.,Lund University,Skåne University Hospital,Sahlgrenska University Hospital, Wallenberg Laboratory4 aut0 (Swepub:gu)xsmigu |
700 | 1 | a Ärnlöv, Johan,d 1970-u Karolinska Institutet,Karolinska Institute,Dalarna University College,Högskolan Dalarna,Medicinsk vetenskap4 aut0 (Swepub:du)jan |
700 | 1 | a Orho-Melander, Marjuu Lund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups4 aut0 (Swepub:lu)endo-mor |
700 | 1 | a Fall, Tove,d 1979-u Uppsala universitet,Science for Life Laboratory, SciLifeLab,Molekylär epidemiologi,Uppsala University, Uppsala, Sweden4 aut0 (Swepub:lu)med-tfa |
710 | 2 | a Uppsala universitetb Molekylär epidemiologi4 org |
773 | 0 | t Nature communicationsd : Springer Science and Business Media LLCg 13:1q 13:1x 2041-1723 |
856 | 4 | u https://doi.org/10.1038/s41467-022-33050-0y Fulltext |
856 | 4 | u https://uu.diva-portal.org/smash/get/diva2:1702787/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
856 | 4 | u https://du.diva-portal.org/smash/get/diva2:1699452/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
856 | 4 | u http://dx.doi.org/10.1038/s41467-022-33050-0x freey FULLTEXT |
856 | 4 8 | u https://gup.ub.gu.se/publication/318756 |
856 | 4 8 | u https://doi.org/10.1038/s41467-022-33050-0 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-486343 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:du-42775 |
856 | 4 8 | u https://lup.lub.lu.se/record/d8e42fb0-02a3-4b26-aec7-0753bc48d677 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:150772680 |
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