Deficiency of mature B cells does not alter the atherogenic response to castration in male mice

Wilhelmson, Anna S KGothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory (författare)

Testosterone deficiency in men is associated with increased atherosclerosis burden and increased cardiovascular risk. In male mice, testosterone deficiency induced by castration increases atherosclerosis as well as mature B cell numbers in spleen. As B cells are potentially pro-atherogenic, we hypothesized that there may be a link between these effects. To address whether mature B cell deficiency alter the atherogenic response to castration, we studied B cell-deficient mu MT and genotype control male mice on an atherosclerosis-prone Apoe(-/-) background that were castrated or sham-operated pre-pubertally and fed a high-fat diet between 8 and 16 weeks of age to accelerate atherosclerosis development. Genotype did not affect the effects of castration on body weight or weights of fat depots and there were no differences in serum cholesterol levels across the four groups. Atherosclerosis assessed by quantification of lesion area in serial sections of the aortic root was significantly increased by castration and by the mu MT mutation, with no significant interaction between genotype and surgery. In conclusion, castration evokes a similar atherogenic response in B cell-deficient mu MT and control mice. These data suggest that atherogenesis following castration is unrelated to the effects of androgens on mature B cell numbers.

Johansson, Inger,1962Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory(Swepub:gu)xjingf (författare)
Fogelstrand, Linda,1974Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory(Swepub:gu)xsvlin (författare)
Fagman, Johan Bourghardt,1980Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för kirurgi,Wallenberglaboratoriet,Institute of Clinical Sciences, Department of Surgery,Wallenberg Laboratory(Swepub:gu)xboujo (författare)
Arnal, J. F. (författare)
Karlsson, M. C. I.Karolinska Institutet (författare)
Tivesten, Åsa,1969Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Wallenberg Laboratory,Institute of Medicine, Department of Molecular and Clinical Medicine(Swepub:gu)xtivas (författare)
Göteborgs universitetWallenberglaboratoriet (creator_code:org_t)

Ingår i:Scientific Reports: Springer Science and Business Media LLC12:12045-2322

Av författaren/redakt...: Wilhelmson, Anna ...; Johansson, Inger ...; Fogelstrand, Lin ...; Fagman, Johan Bo ...; Arnal, J. F.; Karlsson, M. C. ...; visa fler...; Tivesten, Åsa, 1 ...; visa färre...

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Kardiologi

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