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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04333naa a2200481 4500 | |
| 001 | oai:gup.ub.gu.se/324687 | |
| 003 | SwePub | |
| 008 | 240910s2023 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://gup.ub.gu.se/publication/3246872 URI |
| 024 | 7 | a https://doi.org/10.1016/j.sleep.2022.11.0412 DOI |
| 040 | a (SwePub)gu | |
| 041 | a eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Zou, Ding,d 1970u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition4 aut0 (Swepub:gu)xzoudi |
| 245 | 1 0 | a Arterial bicarbonate is associated with hypoxic burden and uncontrolled hypertension in obstructive sleep apnea- The ESADA cohort |
| 264 | 1 | b Elsevier BV,c 2023 |
| 520 | a Objective: Blood bicarbonate concentration plays an important role for obstructive sleep apnea (OSA) patients to maintain acid-base balance. We investigated the association between arterial standard bicarbonate ([HCO3-]) and nocturnal hypoxia as well as comorbid hypertension in OSA.Methods: A cross-sectional analysis of 3329 patients in the European Sleep Apnea Database (ESADA) was performed. Arterial blood gas analysis and lung function test were performed in conjunction with polysomnographic sleep studies. The 4% oxygen desaturation index (ODI), mean and minimum oxygen saturation (SpO2), and percentage of time with SpO2 below 90% (T90%) were used to reflect nocturnal hypoxic burden. Arterial hypertension was defined as a physician diagnosis of hypertension with ongoing antihypertensive medication. Hypertensive patients with SBP/DBP below or above 140/90 mmHg were classified as controlled-, uncontrolled hypertension, respectively.Results: The [HCO3-] level was normal in most patients (average 24.0 +/- 2.5 mmol/L). ODI, T90% increased whereas mean and minimum SpO2 decreased across [HCO3-] tertiles (ANOVA, p = 0.030, <0.001, <0.001, and <0.001, respectively). [HCO3-] was independently associated with ODI, mean SpO2, minimum SpO2, and T90% after adjusting for confounders (b value [95%CI]: 1.21 [0.88-1.54], -0.16 [-0.20 to -0.11], -0.51 [-0.64 to -0.37], 1.76 [1.48-2.04], respectively, all p < 0.001). 1 mmol/L elevation of [HCO3-] was associated with a 4% increased odds of uncontrolled hypertension (OR: 1.04 [1.01-1.08], p = 0.013). Conclusion: We first demonstrated an independent association between [HCO3-] and nocturnal hypoxic burden as well as uncontrolled hypertension in OSA patients. Bicarbonate levels as an adjunctive measure provide insight into the pathophysiology of hypertension in OSA. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng |
| 653 | a Acid base balance | |
| 653 | a Biomarker | |
| 653 | a Blood pressure | |
| 653 | a Chemosensitivity | |
| 653 | a Endotype | |
| 653 | a Precision medicine | |
| 700 | 1 | a Grote, Ludger,d 1964u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition4 aut0 (Swepub:gu)xgrolu |
| 700 | 1 | a Basoglu, O. K.4 aut |
| 700 | 1 | a Verbraecken, J.4 aut |
| 700 | 1 | a Schiza, S.4 aut |
| 700 | 1 | a Sliwinski, P.4 aut |
| 700 | 1 | a Steiropoulos, P.4 aut |
| 700 | 1 | a Lombardi, C.4 aut |
| 700 | 1 | a Hein, H.4 aut |
| 700 | 1 | a Pepin, J. L.4 aut |
| 700 | 1 | a Parati, G.4 aut |
| 700 | 1 | a McNicholas, W. T.4 aut |
| 700 | 1 | a Hedner, Jan A,d 1953u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition4 aut0 (Swepub:gu)xhedja |
| 710 | 2 | a Göteborgs universitetb Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition4 org |
| 773 | 0 | t Sleep Medicined : Elsevier BVg 102, s. 39-45q 102<39-45x 1389-9457 |
| 856 | 4 8 | u https://gup.ub.gu.se/publication/324687 |
| 856 | 4 8 | u https://doi.org/10.1016/j.sleep.2022.11.041 |
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