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FältnamnIndikatorerMetadata
00005900naa a2200673 4500
001oai:gup.ub.gu.se/325012
003SwePub
008240910s2023 | |||||||||||000 ||eng|
009oai:lup.lub.lu.se:450aca49-463b-44b5-b1cd-83d767398a3d
0247 a https://gup.ub.gu.se/publication/3250122 URI
0247 a https://doi.org/10.1186/s13075-023-03015-92 DOI
0247 a https://lup.lub.lu.se/record/450aca49-463b-44b5-b1cd-83d767398a3d2 URI
040 a (SwePub)gud (SwePub)lu
041 a eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Eberhard, Annau Lund University,Lunds universitet,Reumatologi,Forskargrupper vid Lunds universitet,Rheumatology,Lund University Research Groups,Helsingborg Hospital4 aut0 (Swepub:lu)an6316eb
2451 0a Radiographic damage in early rheumatoid arthritis is associated with increased disability but not with pain-a 5-year follow-up study
264 c 2023-02-27
264 1b Springer Science and Business Media LLC,c 2023
520 a ObjectivesTo evaluate how radiographic damage, overall and measured as joint space narrowing score (JSNS) and erosion score (ES), as well as other clinical and laboratory measures, relate to disability and pain in early rheumatoid arthritis (RA).MethodsAn inception cohort of 233 patients with early RA, recruited in 1995-2005, was followed for 5 years. Disability was assessed with the Health Assessment Questionnaire (HAQ), and pain with a visual analogue scale (VAS; 0-100 mm). Radiographs of hands and feet were evaluated using the Sharp-van der Heijde score (SHS), including JSNS and ES. The relation for radiographic scores and other clinical parameters with pain and HAQ were evaluated cross-sectionally by multivariate linear regression analysis and over time using generalized estimating equations.ResultsES was significantly associated with HAQ cross-sectionally at inclusion, after 2 and after 5 years, and over time. Associations for HAQ with SHS and JSNS were weaker and less consistent compared with those for ES. There was no association between radiographic scores and pain at any visit. Both HAQ and pain were associated with parameters of disease activity. The strongest cross-sectional associations were found for the number of tender joints (adjusted p<0.001 at all visits).ConclusionJoint damage was associated with disability already in early RA. Erosions of hands and feet appear to have a greater influence on disability compared with joint space narrowing early in the disease. Pain was associated with other factors than joint destruction in early RA, in particular joint tenderness-suggesting an impact of pain sensitization.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Reumatologi och inflammation0 (SwePub)302102 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Rheumatology and Autoimmunity0 (SwePub)302102 hsv//eng
653 a Rheumatoid arthritis
653 a Pain
653 a Disability
653 a Radiographic damage
653 a disease-activity
653 a physical function
653 a joint damage
653 a functional
653 a disability
653 a classification
653 a progression
653 a impairment
653 a predictors
653 a depression
653 a criteria
653 a Rheumatology
653 a Humans
653 a Follow-Up Studies
653 a Cross-Sectional Studies
653 a Arthritis, Rheumatoid/complications
653 a Pain/diagnostic imaging
653 a Arthralgia
7001 a Rydell, Emilu Lund University,Lunds universitet,Reumatologi,Forskargrupper vid Lunds universitet,Rheumatology,Lund University Research Groups4 aut0 (Swepub:lu)em5271ry
7001 a Forslind, Kristinau Lund University,Lunds universitet,Spenshults artrit grupp,Forskargrupper vid Lunds universitet,Spenshults arthritis group,Lund University Research Groups,Spenshult Research and Development Center4 aut0 (Swepub:lu)med-kfi
7001 a Bergman, Stefanu University of Gothenburg,Lund University,Lunds universitet,Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine,Spenshults artrit grupp,Forskargrupper vid Lunds universitet,Spenshults arthritis group,Lund University Research Groups,Spenshult Research and Development Center4 aut0 (Swepub:lu)med-seb
7001 a Mandl, Thomasu Lund University,Lunds universitet,Reumatologi,Forskargrupper vid Lunds universitet,Rheumatology,Lund University Research Groups4 aut0 (Swepub:lu)medf-tma
7001 a Olofsson, Toru Lund University,Lunds universitet,Reumatologi,Forskargrupper vid Lunds universitet,Rheumatology,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)efor-tol
7001 a Jacobsson, Lennart T. H.,d 1954u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research,Sahlgrenska Academy4 aut0 (Swepub:lu)orto-lja
7001 a Turesson, Carlu Lund University,Lunds universitet,Reumatologi,Forskargrupper vid Lunds universitet,Rheumatology,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)med-ctn
7102 a Reumatologib Forskargrupper vid Lunds universitet4 org
7730 t Arthritis Research & Therapyd : Springer Science and Business Media LLCg 25:1q 25:1x 1478-6354x 1478-6362
8564 u http://dx.doi.org/10.1186/s13075-023-03015-9x freey FULLTEXT
8564 8u https://gup.ub.gu.se/publication/325012
8564 8u https://doi.org/10.1186/s13075-023-03015-9
8564 8u https://lup.lub.lu.se/record/450aca49-463b-44b5-b1cd-83d767398a3d

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