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Sökning: onr:"swepub:oai:gup.ub.gu.se/326494" > The gut microbiota ...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00009526naa a2200757 4500
001oai:gup.ub.gu.se/326494
003SwePub
008240528s2023 | |||||||||||000 ||eng|
009oai:DiVA.org:oru-105579
0247 a https://gup.ub.gu.se/publication/3264942 URI
0247 a https://doi.org/10.1038/s41564-023-01355-52 DOI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-1055792 URI
040 a (SwePub)gud (SwePub)oru
041 a eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Fan, Y.u Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Science, University of Copenhagen, Copenhagen, Denmark4 aut
2451 0a The gut microbiota contributes to the pathogenesis of anorexia nervosa in humans and mice
264 1b Nature Publishing Group,c 2023
500 a Funding agencies:Marie Sklodowska-Curie Individual Fellowship 797267Odense University Hospital Research Fund     R15-A800
520 a Anorexia nervosa (AN) is an eating disorder with a high mortality. About 95% of cases are women and it has a population prevalence of about 1%, but evidence-based treatment is lacking. The pathogenesis of AN probably involves genetics and various environmental factors, and an altered gut microbiota has been observed in individuals with AN using amplicon sequencing and relatively small cohorts. Here we investigated whether a disrupted gut microbiota contributes to AN pathogenesis. Shotgun metagenomics and metabolomics were performed on faecal and serum samples, respectively, from a cohort of 77 females with AN and 70 healthy females. Multiple bacterial taxa (for example, Clostridium species) were altered in AN and correlated with estimates of eating behaviour and mental health. The gut virome was also altered in AN including a reduction in viral-bacterial interactions. Bacterial functional modules associated with the degradation of neurotransmitters were enriched in AN and various structural variants in bacteria were linked to metabolic features of AN. Serum metabolomics revealed an increase in metabolites associated with reduced food intake (for example, indole-3-propionic acid). Causal inference analyses implied that serum bacterial metabolites are potentially mediating the impact of an altered gut microbiota on AN behaviour. Further, we performed faecal microbiota transplantation from AN cases to germ-free mice under energy-restricted feeding to mirror AN eating behaviour. We found that the reduced weight gain and induced hypothalamic and adipose tissue gene expression were related to aberrant energy metabolism and eating behaviour. Our 'omics' and mechanistic studies imply that a disruptive gut microbiome may contribute to AN pathogenesis. Faecal metagenomics and serum metabolomics reveal compositional and functional alterations in the gut microbiota of women with anorexia nervosa, and faecal transplants could transfer an anorexia-associated phenotype to germ-free mice.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Näringslära0 (SwePub)303042 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Nutrition and Dietetics0 (SwePub)303042 hsv//eng
653 a eating-disorders
653 a behavior
653 a mortality
653 a disease
653 a protein
653 a hypothalamus
653 a prevalence
653 a depression
653 a alignment
653 a anxiety
653 a Microbiology
7001 a Stoving, R. K.u Center for Eating Disorders, Odense University Hospital, and Research Unit for Medical Endocrinology, Mental Health Services in the Region of Southern Denmark, Open Patient data Explorative Network (OPEN) and Clinical Institute, University of Southern Denmark, Odense, Denmark4 aut
7001 a Ibraim, S. B.u Université Paris-Saclay, INRAE, MGP, Jouy-en-Josas, France4 aut
7001 a Hyötyläinen, Tuulia,d 1971-u Örebro universitet,Institutionen för naturvetenskap och teknik4 aut0 (Swepub:oru)tihn
7001 a Thirion, F.u Université Paris-Saclay, INRAE, MGP, Jouy-en-Josas, France4 aut
7001 a Arora, T.u Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Science, University of Copenhagen, Copenhagen, Denmark4 aut
7001 a Lyu, L.u Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Science, University of Copenhagen, Copenhagen, Denmark; Department of Medicine, University of Copenhagen and Herlev-Gentofte University Hospital, Copenhagen, Denmark4 aut
7001 a Stankevic, E.u Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Science, University of Copenhagen, Copenhagen, Denmark,Université Paris-Saclay, INRAE, MGP, Jouy-en-Josas, France; Department of Clinical and Movement Neurosciences, University College London, London, UK4 aut
7001 a Hansen, T. H.u Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Science, University of Copenhagen, Copenhagen, Denmark4 aut
7001 a Dechelotte, P.u INSERM U1073 Research Unit and TargEDys, Rouen University, Rouen, France4 aut
7001 a Sinioja, Tim,d 1983-u Örebro universitet,Institutionen för naturvetenskap och teknik4 aut0 (Swepub:oru)tmsa
7001 a Ragnarsdottir, O.u School of Science and Technology, Örebro University, Örebro, Sweden4 aut
7001 a Pons, N.u Université Paris-Saclay, INRAE, MGP, Jouy-en-Josas, France4 aut
7001 a Galleron, N.u Université Paris-Saclay, INRAE, MGP, Jouy-en-Josas, France4 aut
7001 a Quinquis, B.u Université Paris-Saclay, INRAE, MGP, Jouy-en-Josas, France4 aut
7001 a Levenez, F.u Université Paris-Saclay, INRAE, MGP, Jouy-en-Josas, France4 aut
7001 a Roume, H.u Université Paris-Saclay, INRAE, MGP, Jouy-en-Josas, France4 aut
7001 a Falony, G.u Laboratory of Molecular bacteriology, Department of Microbiology and Immunology, Rega Institute Ku Leuven, Leuven, Belgium; Center for Microbiology, VIB, Leuven, Belgium; Institute of Medical Microbiology and Hygiene and Research Center for Immunotherapy (FZI), University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany; Institute of Molecular Biology (IMB), Mainz, Germany4 aut
7001 a Vieira-Silva, S.u Laboratory of Molecular bacteriology, Department of Microbiology and Immunology, Rega Institute Ku Leuven, Leuven, Belgium; Center for Microbiology, VIB, Leuven, Belgium; Institute of Medical Microbiology and Hygiene and Research Center for Immunotherapy (FZI), University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany; Institute of Molecular Biology (IMB), Mainz, Germany4 aut
7001 a Raes, J.u Laboratory of Molecular bacteriology, Department of Microbiology and Immunology, Rega Institute Ku Leuven, Leuven, Belgium; Center for Microbiology, VIB, Leuven, Belgium4 aut
7001 a Clausen, L.u Department of Child and Adolescent Psychiatry, Aarhus University Hospital, Aarhus, Denmark; Department of Clinical Medicine, Faculty of Health, Aarhus University, Aarhus, Denmark4 aut
7001 a Telleus, G. K.u Unit for Psychiatric Research, Aalborg University Hospital, Aalborg, Denmark; Department of Communication and Psychology, The Faculty of Social Sciences and Humanities, Aalborg University, Aalborg, Denmark4 aut
7001 a Bäckhed, Fredrik,d 1973u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Science, University of Copenhagen, Copenhagen, Denmark; The Wallenberg Laboratory, Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Department of Clinical Physiology, Sahlgrenska University Hospital, Region Västra Götaland, Gothenburg, Sweden4 aut0 (Swepub:gu)xbafre
7001 a Oresic, Matej,d 1967-u Örebro universitet,Institutionen för medicinska vetenskaper,Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland4 aut0 (Swepub:oru)moc
7001 a Ehrlich, S. D.4 aut
7001 a Pedersen, O.u Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Science, University of Copenhagen, Copenhagen, Denmark; Department of Medicine, University of Copenhagen and Herlev-Gentofte University Hospital, Copenhagen, Denmark4 aut
7102 a Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Science, University of Copenhagen, Copenhagen, Denmarkb Center for Eating Disorders, Odense University Hospital, and Research Unit for Medical Endocrinology, Mental Health Services in the Region of Southern Denmark, Open Patient data Explorative Network (OPEN) and Clinical Institute, University of Southern Denmark, Odense, Denmark4 org
7730 t Nature Microbiologyd : Nature Publishing Groupg 8, s. 787-802q 8<787-802x 2058-5276
8564 u https://doi.org/10.1038/s41564-023-01355-5y Fulltext
8564 8u https://gup.ub.gu.se/publication/326494
8564 8u https://doi.org/10.1038/s41564-023-01355-5
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-105579

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