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A retrospective cas...
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Mellgren, Karin,1962Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Clinical Sciences, Department of Pediatrics
(författare)
A retrospective case-control study of gastrostomy use in children undergoing hematopoietic cell transplantation
- Artikel/kapitelEngelska2023
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LIBRIS-ID:oai:gup.ub.gu.se/326570
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https://gup.ub.gu.se/publication/326570URI
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https://doi.org/10.1111/petr.14520DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:152580303URI
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BackgroundMaintaining a good nutritional status during the hematopoietic cell transplantation (HCT) procedure is challenging in the pediatric population. MethodsIn a multicentric retrospective study, we compared the outcome of nutritional status and HCT-related parameters in 227 pediatric patients during and after HCT between 2005 and 2015. 112 patients received a gastrostomy before the start of HCT (GS group), and 115 did not receive a gastrostomy (NGS). Data collection was performed at HCT, 3, 6, and 12 months post-HCT. ResultsAt time point of HCT the Standard Deviation Score (SDS) of weight was 0.17 in the NGS group, and 0.71 in the GS group (p = .01) Patients in the NGS group lost more weight during the first 3 months after HCT than patients in the GS group. At 12 months, patients in the NGS remained at a lower weight, while patients in the GS group slightly increased their weight.There were no differences between the groups in the incidence of acute graft-versus-host-disease (GvHD), overall survival, and non-relapse mortality. However, the number of febrile episodes requiring intravenous treatment with antibiotics, was higher in the GS group as compared to the NGS group, during the first 3 months post-HCT (p < .001). ConclusionsOur results indicate that gastrostomy can be utilized in children undergoing HCT without any negative effects on mortality. Therefore, the use of a gastrostomy appears to be a safe option to maintain a good nutritional status during the HCT procedure.
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Nicolajsen, T.
(författare)
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Christoforaki, T. P.
(författare)
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Juan, S. M.
(författare)
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Martensson, T.
(författare)
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Toporski, J.
(författare)
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Casswall, T. H.Karolinska Institutet
(författare)
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Gustafsson, B.Karolinska Institutet
(författare)
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Göteborgs universitetInstitutionen för kliniska vetenskaper, Avdelningen för pediatrik
(creator_code:org_t)
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Ingår i:Pediatric Transplantation27:41397-31421399-3046
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