Sökning: onr:"swepub:oai:gup.ub.gu.se/326674" > The Association of ...
Fältnamn | Indikatorer | Metadata |
---|---|---|
000 | 05740naa a2200769 4500 | |
001 | oai:gup.ub.gu.se/326674 | |
003 | SwePub | |
008 | 240910s2023 | |||||||||||000 ||eng| | |
024 | 7 | a https://gup.ub.gu.se/publication/3266742 URI |
024 | 7 | a https://doi.org/10.2967/jnumed.122.2644342 DOI |
040 | a (SwePub)gu | |
041 | a eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Tissot, C.4 aut |
245 | 1 0 | a The Association of Age-Related and Off-Target Retention with Longitudinal Quantification of 18F MK6240 Tau PET in Target Regions |
264 | c 2022-11-17 | |
264 | 1 | b Society of Nuclear Medicine,c 2023 |
520 | a 6-(fluoro-18F)-3-(1H-pyrrolo[2,3-c]pyridin-1-yl)isoquinolin-5-amine ([18F] MK6240) tau PET tracer quantifies the brain tau neurofibrillary tangle load in Alzheimer disease. The aims of our study were to test the stabil-ity of common reference region estimates in the cerebellum over time and across diagnoses and evaluate the effects of age-related and off -target retention on the longitudinal quantification of [18F]MK6240 in tar-get regions. Methods: We assessed reference, target, age-related, and off-target regions in 125 individuals across the aging and Alzhei-mer disease spectrum with longitudinal [18F]MK6240 SUVs and SUV ratios (SUVRs) (mean +/- SD, 2.25 +/- 0.40 y of follow-up). We obtained SUVR from meninges, exhibiting frequent off-target retention with [18F]MK6240. Additionally, we compared tracer uptake between 37 cognitively unimpaired young (CUY) (mean age, 23.41 +/- 3.33 y) and 27 cognitively unimpaired older (CU) adults (amyloid-P-negative and tau-negative, 58.50 +/- 9.01 y) to identify possible nonvisually apparent, age-related signal. Two-tailed t testing and Pearson correlation testing were used to determine the difference between groups and associa-tions between changes in region uptake, respectively. Results: Inferior cerebellar gray matter SUV did not differ on the basis of diagnosis and amyloid-P status, cross-sectionally and over time. [18F]MK6240 uptake significantly differed between CUY and CU adults in the puta-men or pallidum (affecting-75% of the region) and in the Braak II region (affecting-35%). Changes in meningeal and putamen or palli-dum SUVRs did not significantly differ from zero, nor did they vary across diagnostic groups. We did not observe significant correlations between longitudinal changes in age-related or meningeal off-target retention and changes in target regions, whereas changes in all target regions were strongly correlated. Conclusion: Inferior cerebellar gray matter was similar across diagnostic groups cross-sectionally and sta-ble over time and thus was deemed a suitable reference region for quantification. Despite not being visually perceptible, [18F]MK6240 has age-related retention in subcortical regions, at a much lower magnitude but topographically colocalized with significant off-target signal of the first-generation tau tracers. The lack of correlation between changes in age-related or meningeal and target retention suggests little influence of possible off-target signals on longitudinal tracer quantification. Nev-ertheless, the age-related retention in the Braak II region needs to be further investigated. Future postmortem studies should elucidate the source of the newly reported age-related [18F]MK6240 signal, and in vivo studies should further explore its impact on tracer quantification. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng |
653 | a Key Words | |
653 | a tau | |
653 | a PET | |
653 | a reference region | |
653 | a off-target binding | |
653 | a [F-18]MK6240 | |
653 | a alzheimer-disease | |
653 | a pathology | |
653 | a Radiology | |
653 | a Nuclear Medicine & Medical Imaging | |
700 | 1 | a Servaes, S.4 aut |
700 | 1 | a Lussier, F. Z.4 aut |
700 | 1 | a Ferrai-Souza, J. P.4 aut |
700 | 1 | a Therriault, J.4 aut |
700 | 1 | a Ferreirat, P. C.4 aut |
700 | 1 | a Bezgin, G.4 aut |
700 | 1 | a Bellaver, B.4 aut |
700 | 1 | a Leffa, D. T.4 aut |
700 | 1 | a Mathotaarachchi, S. S.4 aut |
700 | 1 | a Chamoun, M.4 aut |
700 | 1 | a Stevenson, J.4 aut |
700 | 1 | a Rahmouni, N.4 aut |
700 | 1 | a Kang, M. S.4 aut |
700 | 1 | a Pallen, V.4 aut |
700 | 1 | a Margherita-Poltronetti, N.4 aut |
700 | 1 | a Wang, Y. T.4 aut |
700 | 1 | a Fernandez-Arias, J.4 aut |
700 | 1 | a Lessa Benedet, Andréau Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xlesan |
700 | 1 | a Zimmer, E. R.4 aut |
700 | 1 | a Soucy, J. P.4 aut |
700 | 1 | a Tudorascu, D. L.4 aut |
700 | 1 | a Cohen, A. D.4 aut |
700 | 1 | a Sharp, M.4 aut |
700 | 1 | a Gauthier, S.4 aut |
700 | 1 | a Massarweh, G.4 aut |
700 | 1 | a Lopresti, B.4 aut |
700 | 1 | a Klunk, W. E.4 aut |
700 | 1 | a Baker, S. L.4 aut |
700 | 1 | a Villemagne, V. L.4 aut |
700 | 1 | a Rosa-Neto, P.4 aut |
700 | 1 | a Pascoal, T. A.4 aut |
710 | 2 | a Göteborgs universitetb Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi4 org |
773 | 0 | t Journal of Nuclear Medicined : Society of Nuclear Medicineg 64:3, s. 452-459q 64:3<452-459x 0161-5505x 2159-662X |
856 | 4 8 | u https://gup.ub.gu.se/publication/326674 |
856 | 4 8 | u https://doi.org/10.2967/jnumed.122.264434 |
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
Kopiera och spara länken för att återkomma till aktuell vy